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The map label for this gene is fumC [H]

Identifier: 161723165

GI number: 161723165

Start: 1895396

End: 1896790

Strand: Reverse

Name: fumC [H]

Synonym: BTH_I1685

Alternate gene names: 161723165

Gene position: 1896790-1895396 (Counterclockwise)

Preceding gene: 83720398

Following gene: 83720656

Centisome position: 49.79

GC content: 66.24

Gene sequence:

>1395_bases
ATGAGCGAAGCAGTACGGATGGAACGCGACACGTTCGGCGAAATCGCAGTGCCGGCCGCCCGGCTATGGGGCGCGCAGAC
GCAGCGCTCGCTGCAGAACTTCAAGATCTCGACCGAAAAGCAGTCGCCCGAACTGATTCACGCGCTCGCGCTGATCAAGC
GCGCGGCGGCCGCCGTCAATCTCGAACTCGGCGTGCTCGCGCAGGACAAGGCGAACGCGATCATCGCCACCGCCGACGAG
ATCATCGCCGGCCGTCATCCCGATGAATTCCCGCTCGCCGTCTGGCAAACGGGTTCGGGCACGCAGACCAACATGAACCT
CAACGAGGTGATCGCGAACCGCGCGAGCGAGTTGCTCGGCGGCGAGCGAGGCGAAAGCCGCAACGTGCATCCGAACGACG
ACGTCAATCGCGGCCAGTCGTCGAACGACGTGTTCCCGACCGCGATGCACGTCGCCGCCGCGCGCGCGATCGTCGACCAT
CTGCTGCCCGCGCTGCGCACGCTGCGCGCGACGCTCGACGCGAAGGCCGCCGCGTTTGCCGACATCGTGAAGATCGGCCG
CACGCACCTGCAGGACGCGACGCCGCTCACGCTCGGCCAGGAATTCTCCGGCTACGTCGCTCAGCTCGATCAGGGCATTC
GCCACGTCGAGACGGCGCTGCCCCATCTGTACGAGCTCGCGCAAGGCGGCACGGCGGTCGGCACGGGCCTGAACGCGCAT
CCGAAGTTCGCGGCGGGCGTCGCGGCCGAGATCGGCCGGCTCACCGGCTTGCCGTTCGTCAGTGCGCCGAACAAATTCGA
AGTGATGGCCGCGGCCGACGCGCTCGTGTTCGCGCACGGCGCGCTTAAGACGGTCGCCGCGAGCCTCATGAAGATCGCGA
ACGACATCCGCTGGCTCGCGAGCGGGCCGCGTTGCGGGCTCGGCGAGTTGTCGATTCCGGAGAACGAGCCGGGCAGCTCG
ATCATGCCGGGCAAGGTCAATCCGACGCAATCGGAAGCGGTGACGATGCTCTGCTGTCAAGTGTTCGGCAACGACGTCGC
GGTGAACTTCGGCGGCGCGAGCGGCAATTTCGAACTGAACGTGTTCCGGCCGATGATTGCGCACAACGTACTGCAATCGG
TGCGGCTGCTCGCGGACGGCGCGCAGAGCTTCAACGATCACTGCGCGGTCGGCATCGAGCCGAATCGCACGCGCATCGAC
GCACTCCTGAACGAATCGCTGATGCTCGTGACGGCGCTCAATCCGCACATCGGCTACGACAAGGCGGCGCAGATCGCGAA
GAAGGCGCACAAGGAAGGCACGACGCTCAGAGCCGCCGCGCTCGCGCTCGGTTACGTGACCGATGCGCAATTCGACGAAT
GGGTGCGGCCGGCGAAGATGGTCGGCAATAGCTGA

Upstream 100 bases:

>100_bases
TGCTTGCCCATCAGTGGACGCCGTCGCGAGAACGGCTCCATCCCCGCATGCGCATTGCGCCGCGCCCGCGCGGCGTCCCC
CGTCATCTGAAGGAGCAATC

Downstream 100 bases:

>100_bases
CCCTCGACGCGGCGCGCGATGCGCGGCCGGCGTCGCGCACGCGCGGCGGCGTGGCGTGGCGGATGTTCGGTTCGGTCGTC
GGCACCCGATCGACAGCGGT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAIIATADE
IIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRNVHPNDDVNRGQSSNDVFPTAMHVAAARAIVDH
LLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVETALPHLYELAQGGTAVGTGLNAH
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRTRID
ALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLRAAALALGYVTDAQFDEWVRPAKMVGNS

Sequences:

>Translated_464_residues
MSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAIIATADE
IIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRNVHPNDDVNRGQSSNDVFPTAMHVAAARAIVDH
LLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVETALPHLYELAQGGTAVGTGLNAH
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRTRID
ALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLRAAALALGYVTDAQFDEWVRPAKMVGNS
>Mature_463_residues
SEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAIIATADEI
IAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRNVHPNDDVNRGQSSNDVFPTAMHVAAARAIVDHL
LPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVETALPHLYELAQGGTAVGTGLNAHP
KFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPENEPGSSI
MPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRTRIDA
LLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLRAAALALGYVTDAQFDEWVRPAKMVGNS

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.9067245119306, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=48.4848484848485, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=74.0740740740741, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=456, Percent_Identity=39.4736842105263, Blast_Score=346, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=63.695652173913, Blast_Score=598, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=67.2839506172839, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=58.6206896551724, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=60.3448275862069, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=60.3448275862069, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=59.002169197397, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=59.3952483801296, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=52.9284164859002, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49312; Mature: 49180

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVN
CCCCHHCCHHCCCCHHCCHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
LELGVLAQDKANAIIATADEIIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLG
EEEEEEECCCCCEEEEEHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGESRNVHPNDDVNRGQSSNDVFPTAMHVAAARAIVDHLLPALRTLRATLDAKAAAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVETALPHLYELAQGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLA
CCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRTRIDALLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCH
KAAQIAKKAHKEGTTLRAAALALGYVTDAQFDEWVRPAKMVGNS
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVN
CCCHHCCHHCCCCHHCCHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
LELGVLAQDKANAIIATADEIIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLG
EEEEEEECCCCCEEEEEHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGESRNVHPNDDVNRGQSSNDVFPTAMHVAAARAIVDHLLPALRTLRATLDAKAAAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVETALPHLYELAQGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
PKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLA
CCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRTRIDALLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCH
KAAQIAKKAHKEGTTLRAAALALGYVTDAQFDEWVRPAKMVGNS
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]