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The map label for this gene is moeA [H]

Identifier: 83593557

GI number: 83593557

Start: 2581148

End: 2582434

Strand: Direct

Name: moeA [H]

Synonym: Rru_A2222

Alternate gene names: 83593557

Gene position: 2581148-2582434 (Clockwise)

Preceding gene: 83593556

Following gene: 83593559

Centisome position: 59.3

GC content: 70.09

Gene sequence:

>1287_bases
ATGCCCGCTTCTCCCCCACCCTCTTCCCTTCCCCCGCTTTCGGCCGATTGCTTCGACACCGCCGATCGCCTGTTGGCGCT
TGATGACGCCGTCGATCGCCTGCTTGACCTGCTTGGCGCGGTGACGGCGATCGAACGCCTGCCGCTCGACCGGGCGCTGG
GCCGGGTGCTGGCCGAGGATCTGACCAGCGCCCTGGTCATCCCCCCCGACGATAATTCGGCCATGGACGGCTATGGGGTG
CGCTTCGCCGACCTCTCGCCGCAGGCTCCCACCCGCCTGCCCCTCACCTTGCGCGTGCCCGCCGGCCATCCCGCCGACCG
CCCCCTGGGCCCGGGCGAGGCCGCGCGCATCTTCACCGGCGCGCCGATCCCCGAGGGCGTCGACACGGTGATCATGCAGG
AGGTCTGCCACGAGGAGGACGGCTACGTCACCCTGCCCAGTGGCGAAAAGCGCGGCGCCAACGTGCGGCCGGCCGGCGCC
GATGTCGCCATCGGCCAAACCGTGCTGGCCAGCGGTCGGCGCCTGGGTCCGATCGATGTGGCGATGGCCGCCCAGATCGG
CGTGGCCGAGCTGGCGGTGCGCGCCCGCCTGAAGGTCGCGGTCTTCACCACCGGCGACGAGGTGGTCGAACCCGGCCAGC
CGCTGCCGCCGGGCGGCATCTATAATTCCAATCGCCGCGCCCTGCTCGGGCTGCTGAGCACCCTGGGCGCCGAGTGCCTT
GATCTCGGCAACCTGCCCGACCGCCCGGCGCTAATCCAAGGCGCCCTGGCCGAGGCGGCGCGCGCCGCCGATCTGGTCGT
CACCTCGGGCGGGGTGTCGGTGGGCGGCGAGGATCACGTCAAGGACGCGGTGACGGCTTTGGGCTCGCTGGCCTTCTGGC
GCCTGGCACTCAAGCCCGGCAAGCCGCTGGCCTTCGGCACCGTCGCTGGCAAGCCGTTTCTCGGGCTGCCCGGCAATCCG
GTTTCGACCTTCGTCACCTTCTGTCTGGTCGGCCGGCCGGTGGTGTTGCGTCTGGCCGGGGTGACGGGGGAGCAATTACA
GCCGCGCGGCTTCCCGGTGATCGCCGATTTCTCGCTGACCCGCAAACCCGGCCGCCGCGAATTCCTGCGCGGACAATTGC
GCAGCGATTCCAGCGGCGCCATGGTCGTCGCCCCCTTCCCCGTGCAATCGTCCAATGTCGTCAGCTCGATCGTCCAATCC
GACGGGCTGATCGATATCGGCCAAGGGGTGACCGTCGTCTCGCGCGGCGACCGGGTGCGCTTCATTCCCTTTAGCGAGCT
GTTTTAA

Upstream 100 bases:

>100_bases
CACATGGGCCCCGAACACGACGCGCCCCCGTCCCAGGCCCATAATACCCCCCGCTAAGCGGCCCCTTGCCCGCAAGGGCC
GCCCCATCAAGGGATCCCCC

Downstream 100 bases:

>100_bases
AAGCCAAACCCCCGGCCGCTTCTTCTCGCGGCCGGGGGCTGGGCCCGTCAGGCCGCCGAAGCGGAGGCGGAGGCCGCCTT
GTCGTGGGTCCGCCCGACTT

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MPASPPPSSLPPLSADCFDTADRLLALDDAVDRLLDLLGAVTAIERLPLDRALGRVLAEDLTSALVIPPDDNSAMDGYGV
RFADLSPQAPTRLPLTLRVPAGHPADRPLGPGEAARIFTGAPIPEGVDTVIMQEVCHEEDGYVTLPSGEKRGANVRPAGA
DVAIGQTVLASGRRLGPIDVAMAAQIGVAELAVRARLKVAVFTTGDEVVEPGQPLPPGGIYNSNRRALLGLLSTLGAECL
DLGNLPDRPALIQGALAEAARAADLVVTSGGVSVGGEDHVKDAVTALGSLAFWRLALKPGKPLAFGTVAGKPFLGLPGNP
VSTFVTFCLVGRPVVLRLAGVTGEQLQPRGFPVIADFSLTRKPGRREFLRGQLRSDSSGAMVVAPFPVQSSNVVSSIVQS
DGLIDIGQGVTVVSRGDRVRFIPFSELF

Sequences:

>Translated_428_residues
MPASPPPSSLPPLSADCFDTADRLLALDDAVDRLLDLLGAVTAIERLPLDRALGRVLAEDLTSALVIPPDDNSAMDGYGV
RFADLSPQAPTRLPLTLRVPAGHPADRPLGPGEAARIFTGAPIPEGVDTVIMQEVCHEEDGYVTLPSGEKRGANVRPAGA
DVAIGQTVLASGRRLGPIDVAMAAQIGVAELAVRARLKVAVFTTGDEVVEPGQPLPPGGIYNSNRRALLGLLSTLGAECL
DLGNLPDRPALIQGALAEAARAADLVVTSGGVSVGGEDHVKDAVTALGSLAFWRLALKPGKPLAFGTVAGKPFLGLPGNP
VSTFVTFCLVGRPVVLRLAGVTGEQLQPRGFPVIADFSLTRKPGRREFLRGQLRSDSSGAMVVAPFPVQSSNVVSSIVQS
DGLIDIGQGVTVVSRGDRVRFIPFSELF
>Mature_427_residues
PASPPPSSLPPLSADCFDTADRLLALDDAVDRLLDLLGAVTAIERLPLDRALGRVLAEDLTSALVIPPDDNSAMDGYGVR
FADLSPQAPTRLPLTLRVPAGHPADRPLGPGEAARIFTGAPIPEGVDTVIMQEVCHEEDGYVTLPSGEKRGANVRPAGAD
VAIGQTVLASGRRLGPIDVAMAAQIGVAELAVRARLKVAVFTTGDEVVEPGQPLPPGGIYNSNRRALLGLLSTLGAECLD
LGNLPDRPALIQGALAEAARAADLVVTSGGVSVGGEDHVKDAVTALGSLAFWRLALKPGKPLAFGTVAGKPFLGLPGNPV
STFVTFCLVGRPVVLRLAGVTGEQLQPRGFPVIADFSLTRKPGRREFLRGQLRSDSSGAMVVAPFPVQSSNVVSSIVQSD
GLIDIGQGVTVVSRGDRVRFIPFSELF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=392, Percent_Identity=32.9081632653061, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI66932975, Length=392, Percent_Identity=32.9081632653061, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1787049, Length=405, Percent_Identity=40.4938271604938, Blast_Score=279, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI25147659, Length=386, Percent_Identity=28.2383419689119, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=254, Percent_Identity=27.1653543307087, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136978, Length=365, Percent_Identity=31.7808219178082, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24638841, Length=365, Percent_Identity=31.7808219178082, Blast_Score=145, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44531; Mature: 44399

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPPPSSLPPLSADCFDTADRLLALDDAVDRLLDLLGAVTAIERLPLDRALGRVLAED
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LTSALVIPPDDNSAMDGYGVRFADLSPQAPTRLPLTLRVPAGHPADRPLGPGEAARIFTG
HHCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEC
APIPEGVDTVIMQEVCHEEDGYVTLPSGEKRGANVRPAGADVAIGQTVLASGRRLGPIDV
CCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHH
AMAAQIGVAELAVRARLKVAVFTTGDEVVEPGQPLPPGGIYNSNRRALLGLLSTLGAECL
HHHHHHHHHHHHHHEEEEEEEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DLGNLPDRPALIQGALAEAARAADLVVTSGGVSVGGEDHVKDAVTALGSLAFWRLALKPG
HCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEECCC
KPLAFGTVAGKPFLGLPGNPVSTFVTFCLVGRPVVLRLAGVTGEQLQPRGFPVIADFSLT
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCCC
RKPGRREFLRGQLRSDSSGAMVVAPFPVQSSNVVSSIVQSDGLIDIGQGVTVVSRGDRVR
CCCCHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEECCCCEEEEECCCEEE
FIPFSELF
EECHHHCC
>Mature Secondary Structure 
PASPPPSSLPPLSADCFDTADRLLALDDAVDRLLDLLGAVTAIERLPLDRALGRVLAED
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LTSALVIPPDDNSAMDGYGVRFADLSPQAPTRLPLTLRVPAGHPADRPLGPGEAARIFTG
HHCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEC
APIPEGVDTVIMQEVCHEEDGYVTLPSGEKRGANVRPAGADVAIGQTVLASGRRLGPIDV
CCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHH
AMAAQIGVAELAVRARLKVAVFTTGDEVVEPGQPLPPGGIYNSNRRALLGLLSTLGAECL
HHHHHHHHHHHHHHEEEEEEEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DLGNLPDRPALIQGALAEAARAADLVVTSGGVSVGGEDHVKDAVTALGSLAFWRLALKPG
HCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEECCC
KPLAFGTVAGKPFLGLPGNPVSTFVTFCLVGRPVVLRLAGVTGEQLQPRGFPVIADFSLT
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCCC
RKPGRREFLRGQLRSDSSGAMVVAPFPVQSSNVVSSIVQSDGLIDIGQGVTVVSRGDRVR
CCCCHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEECCCCEEEEECCCEEE
FIPFSELF
EECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]