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The map label for this gene is coaE

Identifier: 82703249

GI number: 82703249

Start: 2424239

End: 2424841

Strand: Reverse

Name: coaE

Synonym: Nmul_A2130

Alternate gene names: 82703249

Gene position: 2424841-2424239 (Counterclockwise)

Preceding gene: 82703250

Following gene: 82703248

Centisome position: 76.15

GC content: 60.03

Gene sequence:

>603_bases
ATGCTGGTAATCGGCCTGACTGGGGGCATCGGCAGCGGTAAAACCAGCGCCGCCAATATTTTTTCCGCGCTCGGCGCCGG
CGTGGTCGATACCGATGAGATTGCGCATGAACTTACCCAGTCGGGAGGGCGCAGCCTGCCTGCCATCCGGCGCGCCTTCG
GGGAGAAATACATCACGCCCGAGGGGGCCCTGAACCGCAAGGAAATGCGTAACCTCGTGTTTAACGATACGGATGCGCGT
CGCAAACTGGAGGCTATTCTTCACCCGCTCATCCGGGACGAAGTGTCGCGGAGAGTAGGGCTTGCTCAGGGGCCTTACCT
GATAATCGTGGTTCCGCTGCTGCTTGAGACCGGCCACTACCGGGGAATAGTCCAGCGCGTTCTGGTGGTGGATTGCAGCG
AAGGGGCGCAGATTAGCCGCGCCACTGCGCGCAGTGGAATGAATGAACAGGCAGTGCGGGCCATCATGGTTGCCCAGGTT
TCGCGTGACGAACGGTTGGGGCAGGCGGATGACGTGATTGTCAACAATGCCGACCTTCCCAACCTCGAGCGGCAGGTACG
GGCATTGCACAAGAAATATATGACGCTGGCCCAGGGAAGTTGA

Upstream 100 bases:

>100_bases
GTCCCTATTCCGTTCGGGCCTTATCTGGTGTGTGGGGGAATCGTGGCTCTGTTTTGGGGAAACGAGATCAATAGAGCTTA
CCTGGGGTCATTTTAGCCCC

Downstream 100 bases:

>100_bases
TTTCAACGCACCAGGCGGGTTTCCTGCAGGAGCTTCACATTTGTTGCCTGCGGATTTGGCTGCTAAAATAAGAATTTGAA
ACAATGCCCATCCGCAGTCG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MLVIGLTGGIGSGKTSAANIFSALGAGVVDTDEIAHELTQSGGRSLPAIRRAFGEKYITPEGALNRKEMRNLVFNDTDAR
RKLEAILHPLIRDEVSRRVGLAQGPYLIIVVPLLLETGHYRGIVQRVLVVDCSEGAQISRATARSGMNEQAVRAIMVAQV
SRDERLGQADDVIVNNADLPNLERQVRALHKKYMTLAQGS

Sequences:

>Translated_200_residues
MLVIGLTGGIGSGKTSAANIFSALGAGVVDTDEIAHELTQSGGRSLPAIRRAFGEKYITPEGALNRKEMRNLVFNDTDAR
RKLEAILHPLIRDEVSRRVGLAQGPYLIIVVPLLLETGHYRGIVQRVLVVDCSEGAQISRATARSGMNEQAVRAIMVAQV
SRDERLGQADDVIVNNADLPNLERQVRALHKKYMTLAQGS
>Mature_200_residues
MLVIGLTGGIGSGKTSAANIFSALGAGVVDTDEIAHELTQSGGRSLPAIRRAFGEKYITPEGALNRKEMRNLVFNDTDAR
RKLEAILHPLIRDEVSRRVGLAQGPYLIIVVPLLLETGHYRGIVQRVLVVDCSEGAQISRATARSGMNEQAVRAIMVAQV
SRDERLGQADDVIVNNADLPNLERQVRALHKKYMTLAQGS

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=196, Percent_Identity=35.2040816326531, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI191252795, Length=196, Percent_Identity=35.2040816326531, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI110227607, Length=192, Percent_Identity=31.25, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI110227605, Length=192, Percent_Identity=31.25, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI110227603, Length=192, Percent_Identity=31.25, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI110227601, Length=192, Percent_Identity=31.25, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI205277394, Length=192, Percent_Identity=31.25, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1786292, Length=195, Percent_Identity=40.5128205128205, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17554944, Length=192, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=29.5, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24644728, Length=193, Percent_Identity=29.0155440414508, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24658602, Length=187, Percent_Identity=24.5989304812834, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_NITMU (Q2Y748)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412815.1
- ProteinModelPortal:   Q2Y748
- SMR:   Q2Y748
- STRING:   Q2Y748
- GeneID:   3784756
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2130
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   Q2Y748
- ProtClustDB:   PRK00081
- BioCyc:   NMUL323848:NMUL_A2130-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21695; Mature: 21695

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIGLTGGIGSGKTSAANIFSALGAGVVDTDEIAHELTQSGGRSLPAIRRAFGEKYITP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
EGALNRKEMRNLVFNDTDARRKLEAILHPLIRDEVSRRVGLAQGPYLIIVVPLLLETGHY
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCH
RGIVQRVLVVDCSEGAQISRATARSGMNEQAVRAIMVAQVSRDERLGQADDVIVNNADLP
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCC
NLERQVRALHKKYMTLAQGS
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVIGLTGGIGSGKTSAANIFSALGAGVVDTDEIAHELTQSGGRSLPAIRRAFGEKYITP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
EGALNRKEMRNLVFNDTDARRKLEAILHPLIRDEVSRRVGLAQGPYLIIVVPLLLETGHY
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCH
RGIVQRVLVVDCSEGAQISRATARSGMNEQAVRAIMVAQVSRDERLGQADDVIVNNADLP
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCC
NLERQVRALHKKYMTLAQGS
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA