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The map label for this gene is rnhA

Identifier: 82702746

GI number: 82702746

Start: 1859121

End: 1859588

Strand: Reverse

Name: rnhA

Synonym: Nmul_A1619

Alternate gene names: 82702746

Gene position: 1859588-1859121 (Counterclockwise)

Preceding gene: 82702747

Following gene: 82702745

Centisome position: 58.4

GC content: 53.63

Gene sequence:

>468_bases
GTGAAAGCGAAACTTGCCGAGGTAGTCGAAATATTTACCGATGGAGCCTGCAAAGGGAATCCGGGGGTGGGCGGGTGGGG
CGCCTTGCTGCAATACAACGGGCATAGACGCGAATTATTCGGTGGAGAGAAAATGACCACCAATAATCGTATGGAGTTGC
TCGCTGTCATCCGAGCGCTGGAAGCGCTGACCAAGCCATGTGAAGTACGCTTGCACACCGACTCATTGTATGTACAGAAG
GGTATCAGCGAGTGGATACACGCCTGGAAAAAGCGCGATTGGCGTACCGCCGACAAAAAGCCGGTAAAAAATGATGATTT
GTGGAGAGAACTCGATCTGCTGACGCAGCGCCACAAAATAGAATGGTTATGGGTGCGGGGGCATTCGGGCCATGATGGCA
ACGAATATGCCGATATGCTGGCCAACCGGGGCGTGCAGACGGCTCTGCGGGGTGTTTCCGCAAATTAG

Upstream 100 bases:

>100_bases
AAAGAGCAATGTCGCCGATTGCACGCAAGATCAAAGGCACAGCCGCCACGAATGAGCCGCCCAAGGCTGCACGCATTGGA
ACTTTACCGCAAGGCGAGAA

Downstream 100 bases:

>100_bases
ACGGGTAGCCATCCCCATCAATCTTCTGAAAGTCATTCAACCGGGAGTGATTTTCTGTAAGACAAAGAGGGAAGAGTTAA
ACCGGAGTAATTATCCGCAA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MKAKLAEVVEIFTDGACKGNPGVGGWGALLQYNGHRRELFGGEKMTTNNRMELLAVIRALEALTKPCEVRLHTDSLYVQK
GISEWIHAWKKRDWRTADKKPVKNDDLWRELDLLTQRHKIEWLWVRGHSGHDGNEYADMLANRGVQTALRGVSAN

Sequences:

>Translated_155_residues
MKAKLAEVVEIFTDGACKGNPGVGGWGALLQYNGHRRELFGGEKMTTNNRMELLAVIRALEALTKPCEVRLHTDSLYVQK
GISEWIHAWKKRDWRTADKKPVKNDDLWRELDLLTQRHKIEWLWVRGHSGHDGNEYADMLANRGVQTALRGVSAN
>Mature_155_residues
MKAKLAEVVEIFTDGACKGNPGVGGWGALLQYNGHRRELFGGEKMTTNNRMELLAVIRALEALTKPCEVRLHTDSLYVQK
GISEWIHAWKKRDWRTADKKPVKNDDLWRELDLLTQRHKIEWLWVRGHSGHDGNEYADMLANRGVQTALRGVSAN

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=149, Percent_Identity=35.5704697986577, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786408, Length=133, Percent_Identity=61.6541353383459, Blast_Score=173, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI115532542, Length=155, Percent_Identity=36.7741935483871, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=36.986301369863, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=36.986301369863, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_NITMU (Q2Y8K1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412312.1
- HSSP:   P0A7Y4
- ProteinModelPortal:   Q2Y8K1
- SMR:   Q2Y8K1
- STRING:   Q2Y8K1
- GeneID:   3784851
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1619
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   SKVVIYT
- PhylomeDB:   Q2Y8K1
- BioCyc:   NMUL323848:NMUL_A1619-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 17662; Mature: 17662

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKLAEVVEIFTDGACKGNPGVGGWGALLQYNGHRRELFGGEKMTTNNRMELLAVIRAL
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHEECCCHHHHCCCCCCCCCCHHHHHHHHHHH
EALTKPCEVRLHTDSLYVQKGISEWIHAWKKRDWRTADKKPVKNDDLWRELDLLTQRHKI
HHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCE
EWLWVRGHSGHDGNEYADMLANRGVQTALRGVSAN
EEEEEECCCCCCCHHHHHHHHCCCHHHHHHCCCCC
>Mature Secondary Structure
MKAKLAEVVEIFTDGACKGNPGVGGWGALLQYNGHRRELFGGEKMTTNNRMELLAVIRAL
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHEECCCHHHHCCCCCCCCCCHHHHHHHHHHH
EALTKPCEVRLHTDSLYVQKGISEWIHAWKKRDWRTADKKPVKNDDLWRELDLLTQRHKI
HHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCE
EWLWVRGHSGHDGNEYADMLANRGVQTALRGVSAN
EEEEEECCCCCCCHHHHHHHHCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA