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The map label for this gene is gmd [H]

Identifier: 78779699

GI number: 78779699

Start: 1227408

End: 1228511

Strand: Reverse

Name: gmd [H]

Synonym: PMT9312_1316

Alternate gene names: 78779699

Gene position: 1228511-1227408 (Counterclockwise)

Preceding gene: 78779700

Following gene: 78779698

Centisome position: 71.88

GC content: 34.06

Gene sequence:

>1104_bases
ATGAACTTTAGCACTGATATGAATGACAAGAATATTAAAAAAATTGCATTAATTACTGGAATTACTGGCCAAGATGGTAG
TTATCTTGCAGAATTTTTACTTAATAAGGGATATCAAGTTCATGGGATTAAAAGAAGGTCTAGTAGTCTGAATACATCGA
GAATCGATCATCTTTATCAAGACCCTCACGAATTAAACCAAAATTTTATTCTTCATTATGGTGATTTAACAGACTCTACG
AATTTGATAAGAATTATTCAAGATGTTCAACCGGATGAAATTTACAATTTAGGGGCACAAAGTCACGTGGCAGTAAGCTT
TGAGACACCTGAATATACGGCTAATTGTGATGCATTAGGAACATTAAGAATATTAGAAGCTATAAGAATTTTAGGACTTG
AAAATAAAACAAAAATTTATCAAGCAAGTACTAGTGAGTTATATGGTGAAGTTCAGGAAACTCCGCAAACTGAAAAAACA
CCTTTTTATCCTAGGAGCCCTTATGGGGTGGCCAAAATGTATGCTTATTGGATAACAGTCAATTATAGGGAATCTTATGG
AATATTTGCTTGTAATGGTATTTTATTCAATCATGAGAGTCCTAGAAGAGGCGAGACTTTCGTAACTAAAAAAATTACTA
GAGGTTTAGCAAGGATACATTGTGGTTTGGATGATTGTATTTATTTAGGTAATCTTGATTCATTAAGAGATTGGGGTCAC
GCAAAAGACTACGTCGAGATGCAATGGTTAATGTTACAGCAAGATACTCCAGAGGATTTTGTAATTGCTACTGGAAGAAG
CGAATCCATTAGGCAATTTGTAGAAATTGCAGCTCAAAAGCTAGGTTGGAGTAAGAACGAAAATTCATCTGCAATAATTT
GGGAAGGAGAAGGATTAAATGAAGTTGGAAAACGAAAAGACACAGGAGAAATTGTTGTAAGAATTGATAAAAGGTATTTT
CGCCCCGCTGAAGTTGAAGCTTTAATAGGAGATTCCTCTAAAGCTAGAAAAGAATTAGGATGGGAACCTAAAATCCGCCT
TGAAGAAATGATTGAAGAAATGATCAAATATGATTTGGAGGTATGCAAAGGCTTAGTAAATTAA

Upstream 100 bases:

>100_bases
GGTTATTTCTTATGTTCCTACTTAAATAGAATAAAAAATAAATAAGTTTATCTTTGGATTTATGCAAAGGTAAACAAATA
TACCTAATCAAATTTTTTCT

Downstream 100 bases:

>100_bases
AAAAAGTTACTTATGCATTAATACAAATGTTAACTTTGATTTAAAATAAATTTATACAAGAAATTCTTTTGCAAAAAAAT
CTTCTATTAAACTCAAAAGT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MNFSTDMNDKNIKKIALITGITGQDGSYLAEFLLNKGYQVHGIKRRSSSLNTSRIDHLYQDPHELNQNFILHYGDLTDST
NLIRIIQDVQPDEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAIRILGLENKTKIYQASTSELYGEVQETPQTEKT
PFYPRSPYGVAKMYAYWITVNYRESYGIFACNGILFNHESPRRGETFVTKKITRGLARIHCGLDDCIYLGNLDSLRDWGH
AKDYVEMQWLMLQQDTPEDFVIATGRSESIRQFVEIAAQKLGWSKNENSSAIIWEGEGLNEVGKRKDTGEIVVRIDKRYF
RPAEVEALIGDSSKARKELGWEPKIRLEEMIEEMIKYDLEVCKGLVN

Sequences:

>Translated_367_residues
MNFSTDMNDKNIKKIALITGITGQDGSYLAEFLLNKGYQVHGIKRRSSSLNTSRIDHLYQDPHELNQNFILHYGDLTDST
NLIRIIQDVQPDEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAIRILGLENKTKIYQASTSELYGEVQETPQTEKT
PFYPRSPYGVAKMYAYWITVNYRESYGIFACNGILFNHESPRRGETFVTKKITRGLARIHCGLDDCIYLGNLDSLRDWGH
AKDYVEMQWLMLQQDTPEDFVIATGRSESIRQFVEIAAQKLGWSKNENSSAIIWEGEGLNEVGKRKDTGEIVVRIDKRYF
RPAEVEALIGDSSKARKELGWEPKIRLEEMIEEMIKYDLEVCKGLVN
>Mature_367_residues
MNFSTDMNDKNIKKIALITGITGQDGSYLAEFLLNKGYQVHGIKRRSSSLNTSRIDHLYQDPHELNQNFILHYGDLTDST
NLIRIIQDVQPDEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAIRILGLENKTKIYQASTSELYGEVQETPQTEKT
PFYPRSPYGVAKMYAYWITVNYRESYGIFACNGILFNHESPRRGETFVTKKITRGLARIHCGLDDCIYLGNLDSLRDWGH
AKDYVEMQWLMLQQDTPEDFVIATGRSESIRQFVEIAAQKLGWSKNENSSAIIWEGEGLNEVGKRKDTGEIVVRIDKRYF
RPAEVEALIGDSSKARKELGWEPKIRLEEMIEEMIKYDLEVCKGLVN

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=352, Percent_Identity=60.7954545454545, Blast_Score=463, Evalue=1e-130,
Organism=Escherichia coli, GI1788366, Length=362, Percent_Identity=67.1270718232044, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI48994969, Length=359, Percent_Identity=25.6267409470752, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788353, Length=369, Percent_Identity=22.7642276422764, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17507723, Length=354, Percent_Identity=61.2994350282486, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17539424, Length=353, Percent_Identity=60.6232294617564, Blast_Score=462, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI133901786, Length=353, Percent_Identity=60.6232294617564, Blast_Score=462, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17539422, Length=353, Percent_Identity=60.6232294617564, Blast_Score=462, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI133901788, Length=353, Percent_Identity=60.6232294617564, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI133901790, Length=353, Percent_Identity=60.6232294617564, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24158427, Length=351, Percent_Identity=59.5441595441595, Blast_Score=448, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41958; Mature: 41958

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFSTDMNDKNIKKIALITGITGQDGSYLAEFLLNKGYQVHGIKRRSSSLNTSRIDHLYQ
CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHCCCCCHHHHHHHHC
DPHELNQNFILHYGDLTDSTNLIRIIQDVQPDEIYNLGAQSHVAVSFETPEYTANCDALG
CHHHCCCCEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCCCHHH
TLRILEAIRILGLENKTKIYQASTSELYGEVQETPQTEKTPFYPRSPYGVAKMYAYWITV
HHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEEEEEE
NYRESYGIFACNGILFNHESPRRGETFVTKKITRGLARIHCGLDDCIYLGNLDSLRDWGH
EEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECCCHHHHHCCC
AKDYVEMQWLMLQQDTPEDFVIATGRSESIRQFVEIAAQKLGWSKNENSSAIIWEGEGLN
CCHHHHEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCH
EVGKRKDTGEIVVRIDKRYFRPAEVEALIGDSSKARKELGWEPKIRLEEMIEEMIKYDLE
HHHCCCCCCCEEEEEECHHCCCCHHHEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VCKGLVN
HHHHHCC
>Mature Secondary Structure
MNFSTDMNDKNIKKIALITGITGQDGSYLAEFLLNKGYQVHGIKRRSSSLNTSRIDHLYQ
CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHCCCCCHHHHHHHHC
DPHELNQNFILHYGDLTDSTNLIRIIQDVQPDEIYNLGAQSHVAVSFETPEYTANCDALG
CHHHCCCCEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCCCHHH
TLRILEAIRILGLENKTKIYQASTSELYGEVQETPQTEKTPFYPRSPYGVAKMYAYWITV
HHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEEEEEE
NYRESYGIFACNGILFNHESPRRGETFVTKKITRGLARIHCGLDDCIYLGNLDSLRDWGH
EEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECCCHHHHHCCC
AKDYVEMQWLMLQQDTPEDFVIATGRSESIRQFVEIAAQKLGWSKNENSSAIIWEGEGLN
CCHHHHEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCH
EVGKRKDTGEIVVRIDKRYFRPAEVEALIGDSSKARKELGWEPKIRLEEMIEEMIKYDLE
HHHCCCCCCCEEEEEECHHCCCCHHHEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VCKGLVN
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]