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The map label for this gene is manC [H]

Identifier: 78779697

GI number: 78779697

Start: 1224753

End: 1226183

Strand: Reverse

Name: manC [H]

Synonym: PMT9312_1314

Alternate gene names: 78779697

Gene position: 1226183-1224753 (Counterclockwise)

Preceding gene: 78779698

Following gene: 78779696

Centisome position: 71.74

GC content: 30.05

Gene sequence:

>1431_bases
ATGGAAAAATTAAAATTACAACCAGTTATTCTTTGTGGGGGTAGTGGATCAAGGCTTTGGCCATTATCAAGAGAAAGTTT
TCCTAAGCAATTTTTAAAATTAGTTGGTAATAATAATCAATCTCTTTTACAGAATACAATTTTAAGACTCAAAAAGCTGA
AAAATATAGAATCACCAATTTTAATCTGTAATGAGAAGCATAGATTTATTGTAGCTGAGCAATTAAGGGAAATAAATGTT
AAACCAAAGTCAATTATTCTTGAGCCTGAAGCGAAAAATACCGCACCTGCAGTGGCTGTTGGAGCTATTAGATCAAAAAA
TGATTTGAAAGATTCAATTTTGTTTGTCTTAGCTGCTGATCACTCTATTCAAAATGTTGATAAATATGTCGAAGTTGTTA
AACAAGGTTATGAAGTTGCTTGTAAAGGAAAATTAGTAACTTTTGGAATAATTCCAACTTCCCCAGAAACAGGTTTTGGT
TATATTGAATCGGCTGAAAAACTTACAACTGACATAAAGTCTTCTTCAATAATTAGATTTATAGAGAAACCTGATATTAA
ATTAGCAAGAAAATTAATTTTAGATAAACACTTTTCTTGGAATAGTGGAATGTTTATGTTTAAAGCAAGTAATATTATTG
GTGAATTTACTAAGTATGCGCCAAAGATATTAGAGTCTTGTCATAAATCATTAGAATTTGCAGAATCTGATTTGGATTTT
CTCAGATTAAATGAAAATTATTTCTCAAAATGTCAAGAAATATCTATTGATAATGCAATTATGGAAAAAACTTCTTTTGG
AAGTGTTCTGCCATTAAGTGCAGGCTGGAGTGATATAGGCAGTTGGCAGGCGTTGTGGGAAAATGAGGAAAAAGATAAAA
ATGGAAATTTCATAAGTGGTAAAGTGATCAGTAATAATATAAAAAATTGTTATGTTAGGAGCGAAAATAGAATTATTGCT
TGTTTGGGAGTTGAAGATTTAATAATAATTGAGACTAGTGATTCAATTTTAGTTTCAACAAAATCAGATTCACAAAAAAT
TAAATCTATAGTTAAATCATTAAATGAAAATGGATATCAAGAGGCTAAATCACATAAACAAGCTTATAGGCCTTGGGGAA
ACTATATTTCTATTGCGCAAGATAAAAGGTGGCAGGTTAAGAAAATAACTGTCAATCCAGGATCTTCACTTTCATTACAG
ATGCATCATCATCGTTCTGAGCATTGGATTGTTGTAAAAGGCACTGCTTTGGTTCAGATTGATGAAAGTAAAAAATTATT
GTCGGAGAATGAAAGTGTATATATTCCTCTCGGTTCTAAACATCGTCTTTCAAATCCTGGTAAATTAGATTTAATTCTAA
TTGAAGTGCAAAGTGGATCTTATTTAGGTGAAGATGATATTTATAGATTTAAAGATAATTATGGAAGATAA

Upstream 100 bases:

>100_bases
TATGAAGGAAAATTATCTTGTTAAAGATCAAATAAGTTTGTTTAAGATAAACTATGTTATTTTGAAATAAAAAGAATTAC
TGATATTAATATTATTTTTA

Downstream 100 bases:

>100_bases
ATATTTTTAATTTTTTTTAAATTAATTTTTTAAAAAAAATTTTTATTTTATTAACTCTAAGTTATAGTAAAAGAATTTAT
AAATTACCTATTAATAAACA

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MEKLKLQPVILCGGSGSRLWPLSRESFPKQFLKLVGNNNQSLLQNTILRLKKLKNIESPILICNEKHRFIVAEQLREINV
KPKSIILEPEAKNTAPAVAVGAIRSKNDLKDSILFVLAADHSIQNVDKYVEVVKQGYEVACKGKLVTFGIIPTSPETGFG
YIESAEKLTTDIKSSSIIRFIEKPDIKLARKLILDKHFSWNSGMFMFKASNIIGEFTKYAPKILESCHKSLEFAESDLDF
LRLNENYFSKCQEISIDNAIMEKTSFGSVLPLSAGWSDIGSWQALWENEEKDKNGNFISGKVISNNIKNCYVRSENRIIA
CLGVEDLIIIETSDSILVSTKSDSQKIKSIVKSLNENGYQEAKSHKQAYRPWGNYISIAQDKRWQVKKITVNPGSSLSLQ
MHHHRSEHWIVVKGTALVQIDESKKLLSENESVYIPLGSKHRLSNPGKLDLILIEVQSGSYLGEDDIYRFKDNYGR

Sequences:

>Translated_476_residues
MEKLKLQPVILCGGSGSRLWPLSRESFPKQFLKLVGNNNQSLLQNTILRLKKLKNIESPILICNEKHRFIVAEQLREINV
KPKSIILEPEAKNTAPAVAVGAIRSKNDLKDSILFVLAADHSIQNVDKYVEVVKQGYEVACKGKLVTFGIIPTSPETGFG
YIESAEKLTTDIKSSSIIRFIEKPDIKLARKLILDKHFSWNSGMFMFKASNIIGEFTKYAPKILESCHKSLEFAESDLDF
LRLNENYFSKCQEISIDNAIMEKTSFGSVLPLSAGWSDIGSWQALWENEEKDKNGNFISGKVISNNIKNCYVRSENRIIA
CLGVEDLIIIETSDSILVSTKSDSQKIKSIVKSLNENGYQEAKSHKQAYRPWGNYISIAQDKRWQVKKITVNPGSSLSLQ
MHHHRSEHWIVVKGTALVQIDESKKLLSENESVYIPLGSKHRLSNPGKLDLILIEVQSGSYLGEDDIYRFKDNYGR
>Mature_476_residues
MEKLKLQPVILCGGSGSRLWPLSRESFPKQFLKLVGNNNQSLLQNTILRLKKLKNIESPILICNEKHRFIVAEQLREINV
KPKSIILEPEAKNTAPAVAVGAIRSKNDLKDSILFVLAADHSIQNVDKYVEVVKQGYEVACKGKLVTFGIIPTSPETGFG
YIESAEKLTTDIKSSSIIRFIEKPDIKLARKLILDKHFSWNSGMFMFKASNIIGEFTKYAPKILESCHKSLEFAESDLDF
LRLNENYFSKCQEISIDNAIMEKTSFGSVLPLSAGWSDIGSWQALWENEEKDKNGNFISGKVISNNIKNCYVRSENRIIA
CLGVEDLIIIETSDSILVSTKSDSQKIKSIVKSLNENGYQEAKSHKQAYRPWGNYISIAQDKRWQVKKITVNPGSSLSLQ
MHHHRSEHWIVVKGTALVQIDESKKLLSENESVYIPLGSKHRLSNPGKLDLILIEVQSGSYLGEDDIYRFKDNYGR

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=480, Percent_Identity=48.5416666666667, Blast_Score=484, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 53739; Mature: 53739

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLKLQPVILCGGSGSRLWPLSRESFPKQFLKLVGNNNQSLLQNTILRLKKLKNIESPI
CCCEECCEEEEECCCCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCE
LICNEKHRFIVAEQLREINVKPKSIILEPEAKNTAPAVAVGAIRSKNDLKDSILFVLAAD
EEECCCCCEEEEHHHHHCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEEEECC
HSIQNVDKYVEVVKQGYEVACKGKLVTFGIIPTSPETGFGYIESAEKLTTDIKSSSIIRF
CCHHHHHHHHHHHHCCCCEEECCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEE
IEKPDIKLARKLILDKHFSWNSGMFMFKASNIIGEFTKYAPKILESCHKSLEFAESDLDF
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LRLNENYFSKCQEISIDNAIMEKTSFGSVLPLSAGWSDIGSWQALWENEEKDKNGNFISG
EEECCHHHHHHHHCCCCHHHHHHCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCEEEE
KVISNNIKNCYVRSENRIIACLGVEDLIIIETSDSILVSTKSDSQKIKSIVKSLNENGYQ
EEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
EAKSHKQAYRPWGNYISIAQDKRWQVKKITVNPGSSLSLQMHHHRSEHWIVVKGTALVQI
HHHHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEECEEEEEE
DESKKLLSENESVYIPLGSKHRLSNPGKLDLILIEVQSGSYLGEDDIYRFKDNYGR
CCCHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MEKLKLQPVILCGGSGSRLWPLSRESFPKQFLKLVGNNNQSLLQNTILRLKKLKNIESPI
CCCEECCEEEEECCCCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCE
LICNEKHRFIVAEQLREINVKPKSIILEPEAKNTAPAVAVGAIRSKNDLKDSILFVLAAD
EEECCCCCEEEEHHHHHCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEEEECC
HSIQNVDKYVEVVKQGYEVACKGKLVTFGIIPTSPETGFGYIESAEKLTTDIKSSSIIRF
CCHHHHHHHHHHHHCCCCEEECCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEE
IEKPDIKLARKLILDKHFSWNSGMFMFKASNIIGEFTKYAPKILESCHKSLEFAESDLDF
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LRLNENYFSKCQEISIDNAIMEKTSFGSVLPLSAGWSDIGSWQALWENEEKDKNGNFISG
EEECCHHHHHHHHCCCCHHHHHHCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCEEEE
KVISNNIKNCYVRSENRIIACLGVEDLIIIETSDSILVSTKSDSQKIKSIVKSLNENGYQ
EEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
EAKSHKQAYRPWGNYISIAQDKRWQVKKITVNPGSSLSLQMHHHRSEHWIVVKGTALVQI
HHHHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEECEEEEEE
DESKKLLSENESVYIPLGSKHRLSNPGKLDLILIEVQSGSYLGEDDIYRFKDNYGR
CCCHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]