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The map label for this gene is hisI [H]

Identifier: 78778963

GI number: 78778963

Start: 537159

End: 537818

Strand: Reverse

Name: hisI [H]

Synonym: PMT9312_0578

Alternate gene names: 78778963

Gene position: 537818-537159 (Counterclockwise)

Preceding gene: 78778965

Following gene: 78778962

Centisome position: 31.47

GC content: 32.12

Gene sequence:

>660_bases
ATGACTTATTCAACTAATTTCTCTATAGAAGATCTAAGCTTTGATAATTATGGATTAATCCCTGCAGTAGCACAAGATTG
GCTTGACGGATCAATTCTTATGCTTGCTTGGATGAACAAAGAATCATTGACAATGACTCTTGAAACCAATAACGTTCATT
ACTGGAGTAGATCAAGATCCGAAATCTGGAGAAAAGGAGCTACAAGTGGAAGTACTCAAATACTTAAGGATATAAGATTC
GACTGCGATAATGATTCACTAATTCTTTTGATTGAACAAAATGGATCAGGAGCATGTCACACTGGGGAAAAAAGTTGTTT
TTTCAACGAAATTCAAATTAATCAAAATAATAAAAAAGAGAAAAAAACAACTCCCTTCTCAAATATTTGCTCTGAATTAT
TCCATACCATTAACGAAAGATCAATAAATCCTTCAGACAAAAGTTACACAAATCATTTATTAAAAAAAGGCAGTAATACT
ATTTTAAAAAAAATAGGGGAGGAATCCGCTGAATTTATAATGGCTTGCAAAGATAATAATAAAGATTCAATCTCAAATGA
AGCTGCTGATTTAATTTATCATCTGCAAGTAGCCCTTATGCACAAAGGGGTTGAGTGGAGAGATGTACTTGCTGTTCTAG
AATCAAGAAGAAAAAATTAA

Upstream 100 bases:

>100_bases
TTTTACTGCATGAAAATTTCAGAGAAGGAATATACATCAATTAACTGTTAGTATAATTATCAATAAAACATAATTAATAA
GATTTAACATAACAAACATA

Downstream 100 bases:

>100_bases
ATAATTTAAATTTATAATTTATGATTAATTAATATAAAAATTTGAGAAAAAAATAATAATTAACTAAATAATAATTATTA
ATTAAATATTAATTAATTAT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTYSTNFSIEDLSFDNYGLIPAVAQDWLDGSILMLAWMNKESLTMTLETNNVHYWSRSRSEIWRKGATSGSTQILKDIRF
DCDNDSLILLIEQNGSGACHTGEKSCFFNEIQINQNNKKEKKTTPFSNICSELFHTINERSINPSDKSYTNHLLKKGSNT
ILKKIGEESAEFIMACKDNNKDSISNEAADLIYHLQVALMHKGVEWRDVLAVLESRRKN

Sequences:

>Translated_219_residues
MTYSTNFSIEDLSFDNYGLIPAVAQDWLDGSILMLAWMNKESLTMTLETNNVHYWSRSRSEIWRKGATSGSTQILKDIRF
DCDNDSLILLIEQNGSGACHTGEKSCFFNEIQINQNNKKEKKTTPFSNICSELFHTINERSINPSDKSYTNHLLKKGSNT
ILKKIGEESAEFIMACKDNNKDSISNEAADLIYHLQVALMHKGVEWRDVLAVLESRRKN
>Mature_218_residues
TYSTNFSIEDLSFDNYGLIPAVAQDWLDGSILMLAWMNKESLTMTLETNNVHYWSRSRSEIWRKGATSGSTQILKDIRFD
CDNDSLILLIEQNGSGACHTGEKSCFFNEIQINQNNKKEKKTTPFSNICSELFHTINERSINPSDKSYTNHLLKKGSNTI
LKKIGEESAEFIMACKDNNKDSISNEAADLIYHLQVALMHKGVEWRDVLAVLESRRKN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=201, Percent_Identity=35.3233830845771, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319819, Length=177, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24965; Mature: 24834

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSTNFSIEDLSFDNYGLIPAVAQDWLDGSILMLAWMNKESLTMTLETNNVHYWSRSRS
CCCCCCCCEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCCHH
EIWRKGATSGSTQILKDIRFDCDNDSLILLIEQNGSGACHTGEKSCFFNEIQINQNNKKE
HHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCH
KKTTPFSNICSELFHTINERSINPSDKSYTNHLLKKGSNTILKKIGEESAEFIMACKDNN
HCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHEEEEECCCC
KDSISNEAADLIYHLQVALMHKGVEWRDVLAVLESRRKN
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYSTNFSIEDLSFDNYGLIPAVAQDWLDGSILMLAWMNKESLTMTLETNNVHYWSRSRS
CCCCCCCEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCCHH
EIWRKGATSGSTQILKDIRFDCDNDSLILLIEQNGSGACHTGEKSCFFNEIQINQNNKKE
HHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCH
KKTTPFSNICSELFHTINERSINPSDKSYTNHLLKKGSNTILKKIGEESAEFIMACKDNN
HCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHEEEEECCCC
KDSISNEAADLIYHLQVALMHKGVEWRDVLAVLESRRKN
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]