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The map label for this gene is srpG [H]

Identifier: 78778787

GI number: 78778787

Start: 382066

End: 383052

Strand: Reverse

Name: srpG [H]

Synonym: PMT9312_0402

Alternate gene names: 78778787

Gene position: 383052-382066 (Counterclockwise)

Preceding gene: 78778788

Following gene: 78778781

Centisome position: 22.41

GC content: 37.28

Gene sequence:

>987_bases
ATGGCAAGAATTTATGAGGACAACAGTTTTGCTATTGGAAACACTCCATTAGTAAAATTAAAATCAGTTACTAAAAACGC
AAAAGCTACAGTACTTGCAAAAATTGAAGGTAGAAACCCTGCTTATAGTGTCAAATGTAGGATTGGCGCAAACATGATCT
GGGATGCAGAGAAAAGTGGGAAGCTTACAAAAGATAAAACGATTGTTGAGCCAACTTCTGGAAATACAGGAATTGCTCTA
GCTTTTACTGCTTCAGCAAGAGGTTATAAACTCATCCTTACAATGCCAGAATCTATGTCAATTGAAAGAAGAAGGGTTAT
GGCAGTGTTGGGGGCTGAAATTGTTTTAACAGAGGCTTCTAAAGGTATGCCTGGAGCAATAGCTAAAGCCAAAGAAATTG
CAGAAAGTAATCCTTCTCAATATTTCATGCCTGGTCAATTTGATAATCCAGCAAACCCTGAAATTCATTTCAAAACAACT
GGACCAGAAATCTGGGATGATTGCGATGGTGAAATTGATGTTTTAGTTGCAGGGGTTGGAACTGGCGGAACAATTACAGG
GGTTTCAAGATATATTAAGCAAGAGAAGGGTAAAAATATTACTTCTGTAGCTGTAGAACCATCGCATAGTCCTGTTATTA
CACAGACAATGAATGGGGAAGAGGTTAAATCTGGACCACATAAAATCCAAGGAATAGGAGCAGGATTTATTCCTAAGAAC
CTAGACTTATCAATTGTTGATAAGGTTGAACAGGTAACAAATGACGAGTCAATTGAGATGGCTCTTAGATTAGCAAAAGA
AGAAGGTCTATTAGTTGGAATATCTTGTGGAGCTGCTGCTGCTGCTGCTGTTAGATTAGCTGAACAAGATAAATATGCAG
GAAAAATTATTGTAGTTGTTCTACCTGATTTAGCAGAGAGATATTTATCATCAATTATGTTTAATGAAGTTCCAAGCGGA
ATCATTCAAGAACCAGTCAAAGCTTAA

Upstream 100 bases:

>100_bases
ACTAAATAATTTCTAAATTCCTAGTATTTACCGTATAGAAACTTATATACTCTTTTTCTGAATAATAGTTAGTATTAAAA
TATATTTTCTCAATATATAA

Downstream 100 bases:

>100_bases
ATCTATTTTTCTCCAGTAATGAATCTGGTGAAATATACATAGCATCGCCATAAGAGAAGAATCTAAATTTTTCTTTTATG
GCTTTTTTATACAAATCTAA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MARIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDKYAGKIIVVVLPDLAERYLSSIMFNEVPSG
IIQEPVKA

Sequences:

>Translated_328_residues
MARIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDKYAGKIIVVVLPDLAERYLSSIMFNEVPSG
IIQEPVKA
>Mature_327_residues
ARIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIALA
FTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTG
PEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKNL
DLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDKYAGKIIVVVLPDLAERYLSSIMFNEVPSGI
IQEPVKA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=39.5569620253165, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=39.5569620253165, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=39.5569620253165, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=63.8364779874214, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=39.672131147541, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=49.185667752443, Blast_Score=283, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17562970, Length=319, Percent_Identity=43.8871473354232, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=50.7936507936508, Blast_Score=271, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=45.2768729641694, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=322, Percent_Identity=45.0310559006211, Blast_Score=248, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=41.9213973799127, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=39.8119122257053, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=36.8253968253968, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=137, Percent_Identity=40.1459854014599, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=36.1635220125786, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.1269349845201, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643623, Length=322, Percent_Identity=37.888198757764, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20129101, Length=322, Percent_Identity=37.888198757764, Blast_Score=164, Evalue=5e-41,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34988; Mature: 34856

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CCEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGEIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDKYAGKIIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEE
LPDLAERYLSSIMFNEVPSGIIQEPVKA
CCHHHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure 
ARIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGEIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDKYAGKIIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEE
LPDLAERYLSSIMFNEVPSGIIQEPVKA
CCHHHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]