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The map label for this gene is pyrD [H]

Identifier: 78778587

GI number: 78778587

Start: 193670

End: 194839

Strand: Reverse

Name: pyrD [H]

Synonym: PMT9312_0201

Alternate gene names: 78778587

Gene position: 194839-193670 (Counterclockwise)

Preceding gene: 78778588

Following gene: 78778586

Centisome position: 11.4

GC content: 31.71

Gene sequence:

>1170_bases
ATGAATGAACAGAAGGGGGTATTTAATAAACTTTATAAAAGCTTGATGACCCCTATACTAAAAAAAGACTCTGGAATAGA
TGCAGAATATTTAACTAATTTATCTATTAGCCTTCTATCATTCAGTTCAAGAAAACATAATTGGCCTTTAGTTTCATCAA
TCCTAAAAAATCTAAATGATGAATTATCTATAGTTGATAAAAGGTTAAGTCAGAACATATGTGGAATAAATTTTTGCAAT
CCAATTGGTTTAGCTGCAGGTTTTGACAAAAATGGAAACGCAGCAAATATATGGAAAGATTTTGGTTTTGGATTCGCTGA
ACTTGGTACAGTAACTAAATTTGCCCAAAATGGCAATCCCAAACCGAGGTTATTTAGATTAGCAAAAGAAGAGGCGGCAT
TAAATAGGATGGGTTTCAATAACAATGGTGCTGAGAATCTAGTTAAAAACTTTCTTGAACAAGGTATTGAGTTAAAAAAA
AACAGGAAAAATATTTGTTTGGGAATAAATTTTGGCAAATCTAAAATTACAGGTTTATCTCAAGCAAAAGATGATTATTT
AACTTCTCTAAAATTATTAATTCCATATTGTGATTACGCAGCAATAAACGTAAGTTCTCCAAATACTGAGGGCCTCAGAA
AGTTGCAAGATCCAATTCTTCTAAAAGAACTTCTTAAAGAAATCAAAAAGTTACCTAATTGTCCACCATTATTTGTAAAA
ATTGCGCCAGATTTAAGCCTTAAAGATATTGAAGATATTTGTCAATTAATAATCGAGGAAAACATCAATGGCATAATTGC
TACGAACACCAGCATTGATAGATTAGGTCTTGAGAATAGAAAGATCGAGCAAACAGGATTATTACTTTCTGAAGAGAATG
GAGGATTAAGTGGAAGGCCTCTACAAAAAAAAGCAAATCAAATAATAAAACATATTCATAATTTTGATAAAAAGATTATT
TTAATTGGCGTTGGTGGAATCGATAGTCCTGAGTCAGCTTGGGAAAGGATTTGTTCTGGAGCATCATTAATTCAACTTTA
TACAGGATGGATATATCAGGGGCCACAATTAGTCCCCAATATACTTGAGGGGATTATAAAGCAACTCAATAACCATAAAT
TATCTAATATAAAAGAGGCCGTTGGATCAGGTTTAAAATGGGTTGAATAA

Upstream 100 bases:

>100_bases
AAAGATAAAACAATATTTACTTTTTGAATGGCGTAATTGGAGATTGATTCCTAAAGATAAAAAATATTGGATAATAGAAA
AAAAAGAATCCTAATTTTTT

Downstream 100 bases:

>100_bases
AATCAGAAGATGAATAATGAATAAATCGGACCCTAATGATTACACAAAAGAAGCCATGCATATTTCAAACTTAAAACATG
GAGGAAATGTATATGCAAAT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNEQKGVFNKLYKSLMTPILKKDSGIDAEYLTNLSISLLSFSSRKHNWPLVSSILKNLNDELSIVDKRLSQNICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNPKPRLFRLAKEEAALNRMGFNNNGAENLVKNFLEQGIELKK
NRKNICLGINFGKSKITGLSQAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLKEIKKLPNCPPLFVK
IAPDLSLKDIEDICQLIIEENINGIIATNTSIDRLGLENRKIEQTGLLLSEENGGLSGRPLQKKANQIIKHIHNFDKKII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYQGPQLVPNILEGIIKQLNNHKLSNIKEAVGSGLKWVE

Sequences:

>Translated_389_residues
MNEQKGVFNKLYKSLMTPILKKDSGIDAEYLTNLSISLLSFSSRKHNWPLVSSILKNLNDELSIVDKRLSQNICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNPKPRLFRLAKEEAALNRMGFNNNGAENLVKNFLEQGIELKK
NRKNICLGINFGKSKITGLSQAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLKEIKKLPNCPPLFVK
IAPDLSLKDIEDICQLIIEENINGIIATNTSIDRLGLENRKIEQTGLLLSEENGGLSGRPLQKKANQIIKHIHNFDKKII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYQGPQLVPNILEGIIKQLNNHKLSNIKEAVGSGLKWVE
>Mature_389_residues
MNEQKGVFNKLYKSLMTPILKKDSGIDAEYLTNLSISLLSFSSRKHNWPLVSSILKNLNDELSIVDKRLSQNICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNPKPRLFRLAKEEAALNRMGFNNNGAENLVKNFLEQGIELKK
NRKNICLGINFGKSKITGLSQAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLKEIKKLPNCPPLFVK
IAPDLSLKDIEDICQLIIEENINGIIATNTSIDRLGLENRKIEQTGLLLSEENGGLSGRPLQKKANQIIKHIHNFDKKII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYQGPQLVPNILEGIIKQLNNHKLSNIKEAVGSGLKWVE

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=325, Percent_Identity=38.7692307692308, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1787177, Length=303, Percent_Identity=45.2145214521452, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87082059, Length=337, Percent_Identity=25.5192878338279, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17509475, Length=328, Percent_Identity=38.109756097561, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=39.8203592814371, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=39.8203592814371, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 43153; Mature: 43153

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQKGVFNKLYKSLMTPILKKDSGIDAEYLTNLSISLLSFSSRKHNWPLVSSILKNLND
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCH
ELSIVDKRLSQNICGINFCNPIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNP
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
KPRLFRLAKEEAALNRMGFNNNGAENLVKNFLEQGIELKKNRKNICLGINFGKSKITGLS
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHCCCCCEEEEEECCHHHHCCHH
QAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLKEIKKLPNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEE
IAPDLSLKDIEDICQLIIEENINGIIATNTSIDRLGLENRKIEQTGLLLSEENGGLSGRP
ECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCCHHHCCEEECCCCCCCCCC
LQKKANQIIKHIHNFDKKIILIGVGGIDSPESAWERICSGASLIQLYTGWIYQGPQLVPN
HHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
ILEGIIKQLNNHKLSNIKEAVGSGLKWVE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNEQKGVFNKLYKSLMTPILKKDSGIDAEYLTNLSISLLSFSSRKHNWPLVSSILKNLND
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCH
ELSIVDKRLSQNICGINFCNPIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNP
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
KPRLFRLAKEEAALNRMGFNNNGAENLVKNFLEQGIELKKNRKNICLGINFGKSKITGLS
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHCCCCCEEEEEECCHHHHCCHH
QAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLKEIKKLPNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEE
IAPDLSLKDIEDICQLIIEENINGIIATNTSIDRLGLENRKIEQTGLLLSEENGGLSGRP
ECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCCHHHCCEEECCCCCCCCCC
LQKKANQIIKHIHNFDKKIILIGVGGIDSPESAWERICSGASLIQLYTGWIYQGPQLVPN
HHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
ILEGIIKQLNNHKLSNIKEAVGSGLKWVE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]