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The map label for this gene is purE [H]

Identifier: 78778555

GI number: 78778555

Start: 162335

End: 162871

Strand: Reverse

Name: purE [H]

Synonym: PMT9312_0169

Alternate gene names: 78778555

Gene position: 162871-162335 (Counterclockwise)

Preceding gene: 78778557

Following gene: 78778552

Centisome position: 9.53

GC content: 33.52

Gene sequence:

>537_bases
TTGTCAGAATTGAATTCTAAAGATATTTATAAAATCGCTGTCGTAATGGGTAGTGATTCAGATCTAAAAACATTGAAACC
TGCTATTGACATTTTAAGAGAATTTGGAATACAAACTGAAGTTTGTATACTTTCTGCCCATAGAACACCTATTGAGATGA
TGGAATATGCAAAAAATGCAGAATCAGAAAAAATAAAAGTAATAATTGCCGGTGCTGGTGGTGCCGCTCATCTTCCAGGA
ATGTTGGCATCGATAACTTGCATTCCTGTAATTGGTGTACCAGTAGAGAGTAAAACACTTAAGGGGATTGACTCTCTTTT
ATCAATTGTTCAAATGCCTGCTGGGATACCAGTAGCAACAGTTGCAATTAATGGAGGTCAAAATGCTGGATTATTGGCAA
TAGAGATGATCAGTTTATTTGATGAATCCATAAAGAAAAATTTAAAAGAATTCAGAGAAAATCTTCATACACAGGTAAGA
ACTAAAAATAGTAAGTTATCAAATATTGGAGCGGACAATTATCTTCAAAATAAATGA

Upstream 100 bases:

>100_bases
TTTGATGTCATAATATTCAATGGAAATTTATTCTTTTTATCCTAACTAACTGGCGCTAAATTAATTGCACGCCATTATAG
GAAAGAATTGATTTGTTATT

Downstream 100 bases:

>100_bases
ACTTATATTTCTCTATTAACCCTTTTTAAGGAAGTTTTCTTTTTTAAGATAGTTAATAACTTTTTCAACAGAATCCTTTA
AATCTAACGAACCTGTATCA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSELNSKDIYKIAVVMGSDSDLKTLKPAIDILREFGIQTEVCILSAHRTPIEMMEYAKNAESEKIKVIIAGAGGAAHLPG
MLASITCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGGQNAGLLAIEMISLFDESIKKNLKEFRENLHTQVR
TKNSKLSNIGADNYLQNK

Sequences:

>Translated_178_residues
MSELNSKDIYKIAVVMGSDSDLKTLKPAIDILREFGIQTEVCILSAHRTPIEMMEYAKNAESEKIKVIIAGAGGAAHLPG
MLASITCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGGQNAGLLAIEMISLFDESIKKNLKEFRENLHTQVR
TKNSKLSNIGADNYLQNK
>Mature_177_residues
SELNSKDIYKIAVVMGSDSDLKTLKPAIDILREFGIQTEVCILSAHRTPIEMMEYAKNAESEKIKVIIAGAGGAAHLPGM
LASITCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGGQNAGLLAIEMISLFDESIKKNLKEFRENLHTQVRT
KNSKLSNIGADNYLQNK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=54.0540540540541, Blast_Score=128, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324702, Length=167, Percent_Identity=51.497005988024, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 19147; Mature: 19015

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELNSKDIYKIAVVMGSDSDLKTLKPAIDILREFGIQTEVCILSAHRTPIEMMEYAKNA
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCC
ESEKIKVIIAGAGGAAHLPGMLASITCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVAT
CCCEEEEEEECCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEE
VAINGGQNAGLLAIEMISLFDESIKKNLKEFRENLHTQVRTKNSKLSNIGADNYLQNK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
SELNSKDIYKIAVVMGSDSDLKTLKPAIDILREFGIQTEVCILSAHRTPIEMMEYAKNA
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCC
ESEKIKVIIAGAGGAAHLPGMLASITCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVAT
CCCEEEEEEECCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEE
VAINGGQNAGLLAIEMISLFDESIKKNLKEFRENLHTQVRTKNSKLSNIGADNYLQNK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]