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The map label for this gene is csd [H]

Identifier: 78778457

GI number: 78778457

Start: 76097

End: 77350

Strand: Reverse

Name: csd [H]

Synonym: PMT9312_0072

Alternate gene names: 78778457

Gene position: 77350-76097 (Counterclockwise)

Preceding gene: 78778458

Following gene: 78778455

Centisome position: 4.53

GC content: 30.86

Gene sequence:

>1254_bases
ATGGAAACGATTCAAAATTTTCCTGAAATAACCAAGAAAGACTTTCCTCTTTTAAATAAGAATTTAACAAATAATGAGCA
AATCATTTATTTAGACCATGCTGCGACTACTCAAAAACCGATACAGGTCTTAAAAAAAATTGATGAATATTACAGAAACT
TTAATGCCAATGTACATAGAGGTGCGCATCAATTAAGTGCTAAAGCAACAGAAGAGTTTGAAAATGCAAGATATTTAATT
AGTAAATATATAAAAGCGAATTCAACAAAAGAAATTATTTTTACAAGAAATGCTACTGAAGCAATTAATCTCGCAGCTAG
ATCATGGGGTGAATCTTCTTTGAAAGAAAATGATGAAATTCTCTTGTCAATAATGGAACATCATAGCAATATTGTGCCTT
GGCAAATGGTTGCAGCAAAAAATAAATGCAAATTAAAATTTATAGGTATAGATAAAAATGGAAAATTAGATATTGATGAT
TTTAAATCTAAATTAACATCAAGAACAAAACTTGTTAGCATCGTACATATAAGCAACACACTAGGTTGCTGCAATCCAAT
CAAAGAGATAACTAAATTAGCCAAGCAAAAAGGTTCTTTAGTGCTAATAGATGCATGCCAAAGTTTAGCTCATCAAAAAC
TGGATGTAATTGATCTTGATATAGACTTTTTAGCGGGTTCAGGACATAAACTTTGTGGTCCAACAGGTATTGGTTTCCTC
TGGTCAAGACAAGAAATTCTAGAAAAGATTCCTCCTCTCTTTGGTGGTGGCGAAATGATTCAAGATGTTTTTGAAGAGAC
AAGTACTTGGGCAGAACTACCACATAAATTTGAAGCTGGAACTCCTGCTATTGCAGAAGCCATAGGTCTGGCAGAGGCAA
TAAATTACATAAACAATATTGGATTGAATAATATTCATAAATATGAAAAAAATATTACTAAATATTTATTTAAAAAATTA
AATCAGATAGAAGATATTGAAATTATCGGTCCATCTCCAGAGATAGATCCAGACAGAGCATCACTTGCTACTTTTTATAT
AAAAAATATACATGCAAACGATATTGCTGAAATTCTTGATTCGAAAGGAATTTGTATCAGAAGTGGACATCATTGCTGTC
AACCTCTGCACAGATATATCGGAATTAAATCAACGGCTAGGATTAGCATGAATTTCACAACCAATAAAGAAGAGATTGAT
ATATTTTTAGAAAAATTGAAAGAGACTATTAATTTTCTAAAAATGTATTCTTAA

Upstream 100 bases:

>100_bases
GTAAACTACAATTAAGTTCTTACTTTCAAGAAATAATTTCATTTATTCCCGTTGTAAAAGACAGATGGGATTTGCTTGAT
AAACTTTTAAATGAGAATTA

Downstream 100 bases:

>100_bases
ATATTCAAAGCGTTTTTTAAAAATTCCTGAGATTTTTTCATTACTAATTCCTTAGTTTCAATATTTTTAAAACCATGACC
CTCATTTTCGAAAAAAATAG

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
METIQNFPEITKKDFPLLNKNLTNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHRGAHQLSAKATEEFENARYLI
SKYIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEILLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGKLDIDD
FKSKLTSRTKLVSIVHISNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
WSRQEILEKIPPLFGGGEMIQDVFEETSTWAELPHKFEAGTPAIAEAIGLAEAINYINNIGLNNIHKYEKNITKYLFKKL
NQIEDIEIIGPSPEIDPDRASLATFYIKNIHANDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
IFLEKLKETINFLKMYS

Sequences:

>Translated_417_residues
METIQNFPEITKKDFPLLNKNLTNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHRGAHQLSAKATEEFENARYLI
SKYIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEILLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGKLDIDD
FKSKLTSRTKLVSIVHISNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
WSRQEILEKIPPLFGGGEMIQDVFEETSTWAELPHKFEAGTPAIAEAIGLAEAINYINNIGLNNIHKYEKNITKYLFKKL
NQIEDIEIIGPSPEIDPDRASLATFYIKNIHANDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
IFLEKLKETINFLKMYS
>Mature_417_residues
METIQNFPEITKKDFPLLNKNLTNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHRGAHQLSAKATEEFENARYLI
SKYIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEILLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGKLDIDD
FKSKLTSRTKLVSIVHISNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
WSRQEILEKIPPLFGGGEMIQDVFEETSTWAELPHKFEAGTPAIAEAIGLAEAINYINNIGLNNIHKYEKNITKYLFKKL
NQIEDIEIIGPSPEIDPDRASLATFYIKNIHANDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
IFLEKLKETINFLKMYS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=401, Percent_Identity=23.6907730673317, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI156713448, Length=328, Percent_Identity=26.5243902439024, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=41.5841584158416, Blast_Score=354, Evalue=7e-99,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=31.5270935960591, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=24.6882793017456, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI25143064, Length=271, Percent_Identity=29.8892988929889, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI193211090, Length=399, Percent_Identity=25.31328320802, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=397, Percent_Identity=25.9445843828715, Blast_Score=125, Evalue=9e-30,
Organism=Drosophila melanogaster, GI20129463, Length=284, Percent_Identity=29.2253521126761, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47142; Mature: 47142

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIQNFPEITKKDFPLLNKNLTNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHR
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHH
GAHQLSAKATEEFENARYLISKYIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHCCCHHH
LLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGKLDIDDFKSKLTSRTKLVSIVHISNT
HHHHHHHCCCCCCHHHEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCC
LGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
CCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEEEEHEECCCCCCCCCCCCCCHH
WSRQEILEKIPPLFGGGEMIQDVFEETSTWAELPHKFEAGTPAIAEAIGLAEAINYINNI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GLNNIHKYEKNITKYLFKKLNQIEDIEIIGPSPEIDPDRASLATFYIKNIHANDIAEILD
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHC
SKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEIDIFLEKLKETINFLKMYS
CCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METIQNFPEITKKDFPLLNKNLTNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHR
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHH
GAHQLSAKATEEFENARYLISKYIKANSTKEIIFTRNATEAINLAARSWGESSLKENDEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHCCCHHH
LLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGKLDIDDFKSKLTSRTKLVSIVHISNT
HHHHHHHCCCCCCHHHEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCC
LGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
CCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEEEEHEECCCCCCCCCCCCCCHH
WSRQEILEKIPPLFGGGEMIQDVFEETSTWAELPHKFEAGTPAIAEAIGLAEAINYINNI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GLNNIHKYEKNITKYLFKKLNQIEDIEIIGPSPEIDPDRASLATFYIKNIHANDIAEILD
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHC
SKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEIDIFLEKLKETINFLKMYS
CCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]