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The map label for this gene is 78778456

Identifier: 78778456

GI number: 78778456

Start: 74175

End: 76100

Strand: Direct

Name: 78778456

Synonym: PMT9312_0071

Alternate gene names: NA

Gene position: 74175-76100 (Clockwise)

Preceding gene: 78778450

Following gene: 78778461

Centisome position: 4.34

GC content: 27.83

Gene sequence:

>1926_bases
ATGAGTAATGATGATAAATTACAAGTTAGACAAAATCTATCTAAAACAAATTCTTTTAAGGAATTAACTATTATTAGGGA
TACCATTTTTTGGATTGATTTTGTTGGTGAAGGTCAAAATCAAAATGCCATTTTTGCAAGACCATTTTATGAGAAAGATG
CATTTCCTCAAAAATTAACTAATAAAAAATATCTTATTAAAAATAATTTTCATGGATATGGTGGTAAATCTTATAAATGC
ATAGATTTTAAAAATAATTTTTATTTGATTTGGATAGATCAGTTTTCAAAGGCAGTATGGTTTGAAATTTTTAAAAATGC
GGGAATAACAGATAAAAGTCAAAACAAATATCTTGAATCAGTTCAAGAACCGCGGCAGCTATCTAAATCAATAGAAGGAA
ATTTTGATTCTTCATTTGTTATTTCTGAAAAAGATTTTTTGTACGGTATTTGTGAAATAAATAATAGTGATTATTTATTT
TCTTTAAACCTAAATAAAAATGAACAAGATATTTATCTAATAAAAAAATTTAAAAATTTTGCCGGCGATTTATCTTCAAA
TACTTCTGTAAGCTTACTTTCTTGGATAGAGTGGGATTCTCCATATATGCCATGGGAAAAAAATAACCTCTTTTTTGCTC
AAATGGACTTAGATGGAGAGATAAAGCAACTAAAAAAGTTCTCAAACGAACTGGTTAATACCAAAAAGAATGTTTCTTTT
TTTCAACCTTATTGGATTAGTGAAAAAATTTTAGTATGTTCTGAAGATAGTTCTGGATGGTGGAACTTATTGTTTCTAGA
TGTTAGTGAAATTGAGAGTATTTTTATTACGAAAAGAATAAAGAGAAATTGGATTGAATATGGAGCACCTCAATGGGTTT
CAGGAATTGCATTTTTTTCAGGAACTTTACAAAATTTATTTTGTTTGGCAAAAAAAGAAAATAGTTGGATATTGGAACAA
TATAAAGATCTTGCATTTTTTAAAAAATTTTCTACTCCTTTTACTGCAGTAAGTGATTTTAGTGTTTTTGAGAAGAAAGT
TGTTTTAAAAGGTTTTGGATCTGATTTTTTGGGTAATTTATTTGAAATTGATTTCAAAGAAAAAGTTTCATCAGATTTTT
TTGAGGAAATAAATGTTGAACATATAAAGGATTGTTCAAAACCCGAATCATTTTGGTTTAAAGGTTTTGAAGATAAATTA
ACTCATTCTTTTCTGTATAGGCCGCTTGTTGAAAAATTTAGAAAACCACCTCTCTTGGTTAGAGCTCATAGTGGACCAAC
TTCATGTTTTGATGGCTCCTATAATGCTGAAGTTCAATATTGGACTGCTCAAGGATTTTTTGTTGCTGAAGTTAATTATG
GAGGATCATCTGGGTTTGGGAAAGTGTATAGAGAAAGGTTGAACTATAAGTGGGGAATTGTTGATTCTTATGATTGCAAA
GCACTAGCACTTGAATTACTTAAATTAAATCTAGTTGATAGTGAAAAAGTAGTAATTTTTGGTAATAGTGCTGGTGGATT
CACCGCTCTAAATTGCTTATCGTATGGGTCTATTTTTACAGCTGCAATTTGTAAATATCCTGTGATAGATCTTAAGGAGA
TGCATTACAAAACCCATAGGTTTGAAAAAGATTATTTAAATTCTTTGGTAGGAGATTATGAAAAAAACCATGATAAATAT
ATATATAGATCGCCTATAAATCGAATTAACAAAATAAAAAAACCTATCTTATTGTTTCATGGCAAAAAAGATTCAGTTAT
CTCATATGAACAAACTTTAAAAATTCAAGAGATATTGATTCGGAATAATAAATTTTCAGAAGCTATTTTTTTCGAAAATG
AGGGTCATGGTTTTAAAAATATTGAAACTAAGGAATTAGTAATGAAAAAATCTCAGGAATTTTTAAAAAACGCTTTGAAT
ATTTAA

Upstream 100 bases:

>100_bases
GTGAAAAATGGTTTGCCACGTTAATAAAAAAAAGTTTTTAATGAAGACTTTAGCTATAAAAATACTAGCACTTTAATTTA
CTTTCTTTATAGTTTTATAA

Downstream 100 bases:

>100_bases
GAATACATTTTTAGAAAATTAATAGTCTCTTTCAATTTTTCTAAAAATATATCAATCTCTTCTTTATTGGTTGTGAAATT
CATGCTAATCCTAGCCGTTG

Product: esterase/lipase/thioesterase family protein

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSNDDKLQVRQNLSKTNSFKELTIIRDTIFWIDFVGEGQNQNAIFARPFYEKDAFPQKLTNKKYLIKNNFHGYGGKSYKC
IDFKNNFYLIWIDQFSKAVWFEIFKNAGITDKSQNKYLESVQEPRQLSKSIEGNFDSSFVISEKDFLYGICEINNSDYLF
SLNLNKNEQDIYLIKKFKNFAGDLSSNTSVSLLSWIEWDSPYMPWEKNNLFFAQMDLDGEIKQLKKFSNELVNTKKNVSF
FQPYWISEKILVCSEDSSGWWNLLFLDVSEIESIFITKRIKRNWIEYGAPQWVSGIAFFSGTLQNLFCLAKKENSWILEQ
YKDLAFFKKFSTPFTAVSDFSVFEKKVVLKGFGSDFLGNLFEIDFKEKVSSDFFEEINVEHIKDCSKPESFWFKGFEDKL
THSFLYRPLVEKFRKPPLLVRAHSGPTSCFDGSYNAEVQYWTAQGFFVAEVNYGGSSGFGKVYRERLNYKWGIVDSYDCK
ALALELLKLNLVDSEKVVIFGNSAGGFTALNCLSYGSIFTAAICKYPVIDLKEMHYKTHRFEKDYLNSLVGDYEKNHDKY
IYRSPINRINKIKKPILLFHGKKDSVISYEQTLKIQEILIRNNKFSEAIFFENEGHGFKNIETKELVMKKSQEFLKNALN
I

Sequences:

>Translated_641_residues
MSNDDKLQVRQNLSKTNSFKELTIIRDTIFWIDFVGEGQNQNAIFARPFYEKDAFPQKLTNKKYLIKNNFHGYGGKSYKC
IDFKNNFYLIWIDQFSKAVWFEIFKNAGITDKSQNKYLESVQEPRQLSKSIEGNFDSSFVISEKDFLYGICEINNSDYLF
SLNLNKNEQDIYLIKKFKNFAGDLSSNTSVSLLSWIEWDSPYMPWEKNNLFFAQMDLDGEIKQLKKFSNELVNTKKNVSF
FQPYWISEKILVCSEDSSGWWNLLFLDVSEIESIFITKRIKRNWIEYGAPQWVSGIAFFSGTLQNLFCLAKKENSWILEQ
YKDLAFFKKFSTPFTAVSDFSVFEKKVVLKGFGSDFLGNLFEIDFKEKVSSDFFEEINVEHIKDCSKPESFWFKGFEDKL
THSFLYRPLVEKFRKPPLLVRAHSGPTSCFDGSYNAEVQYWTAQGFFVAEVNYGGSSGFGKVYRERLNYKWGIVDSYDCK
ALALELLKLNLVDSEKVVIFGNSAGGFTALNCLSYGSIFTAAICKYPVIDLKEMHYKTHRFEKDYLNSLVGDYEKNHDKY
IYRSPINRINKIKKPILLFHGKKDSVISYEQTLKIQEILIRNNKFSEAIFFENEGHGFKNIETKELVMKKSQEFLKNALN
I
>Mature_640_residues
SNDDKLQVRQNLSKTNSFKELTIIRDTIFWIDFVGEGQNQNAIFARPFYEKDAFPQKLTNKKYLIKNNFHGYGGKSYKCI
DFKNNFYLIWIDQFSKAVWFEIFKNAGITDKSQNKYLESVQEPRQLSKSIEGNFDSSFVISEKDFLYGICEINNSDYLFS
LNLNKNEQDIYLIKKFKNFAGDLSSNTSVSLLSWIEWDSPYMPWEKNNLFFAQMDLDGEIKQLKKFSNELVNTKKNVSFF
QPYWISEKILVCSEDSSGWWNLLFLDVSEIESIFITKRIKRNWIEYGAPQWVSGIAFFSGTLQNLFCLAKKENSWILEQY
KDLAFFKKFSTPFTAVSDFSVFEKKVVLKGFGSDFLGNLFEIDFKEKVSSDFFEEINVEHIKDCSKPESFWFKGFEDKLT
HSFLYRPLVEKFRKPPLLVRAHSGPTSCFDGSYNAEVQYWTAQGFFVAEVNYGGSSGFGKVYRERLNYKWGIVDSYDCKA
LALELLKLNLVDSEKVVIFGNSAGGFTALNCLSYGSIFTAAICKYPVIDLKEMHYKTHRFEKDYLNSLVGDYEKNHDKYI
YRSPINRINKIKKPILLFHGKKDSVISYEQTLKIQEILIRNNKFSEAIFFENEGHGFKNIETKELVMKKSQEFLKNALNI

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=220, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI18765694, Length=250, Percent_Identity=23.2, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552908, Length=471, Percent_Identity=29.723991507431, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI25149159, Length=179, Percent_Identity=28.4916201117318, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550825, Length=232, Percent_Identity=26.2931034482759, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45553511, Length=232, Percent_Identity=26.2931034482759, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551969, Length=232, Percent_Identity=26.2931034482759, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 74814; Mature: 74683

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDDKLQVRQNLSKTNSFKELTIIRDTIFWIDFVGEGQNQNAIFARPFYEKDAFPQKLT
CCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHC
NKKYLIKNNFHGYGGKSYKCIDFKNNFYLIWIDQFSKAVWFEIFKNAGITDKSQNKYLES
CCEEEEECCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VQEPRQLSKSIEGNFDSSFVISEKDFLYGICEINNSDYLFSLNLNKNEQDIYLIKKFKNF
HHHHHHHHHHHCCCCCCEEEEECCCEEEEEEEECCCCEEEEEECCCCCCCEEHEEHHHHH
AGDLSSNTSVSLLSWIEWDSPYMPWEKNNLFFAQMDLDGEIKQLKKFSNELVNTKKNVSF
CCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCE
FQPYWISEKILVCSEDSSGWWNLLFLDVSEIESIFITKRIKRNWIEYGAPQWVSGIAFFS
ECCEECCCEEEEEECCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GTLQNLFCLAKKENSWILEQYKDLAFFKKFSTPFTAVSDFSVFEKKVVLKGFGSDFLGNL
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHCCHH
FEIDFKEKVSSDFFEEINVEHIKDCSKPESFWFKGFEDKLTHSFLYRPLVEKFRKPPLLV
EEECHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEE
RAHSGPTSCFDGSYNAEVQYWTAQGFFVAEVNYGGSSGFGKVYRERLNYKWGIVDSYDCK
EECCCCCCCCCCCCCCEEEEEEECCEEEEEEECCCCCCHHHHHHHHCCCEECCCCCCCHH
ALALELLKLNLVDSEKVVIFGNSAGGFTALNCLSYGSIFTAAICKYPVIDLKEMHYKTHR
HHHHHHHHHEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FEKDYLNSLVGDYEKNHDKYIYRSPINRINKIKKPILLFHGKKDSVISYEQTLKIQEILI
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHH
RNNKFSEAIFFENEGHGFKNIETKELVMKKSQEFLKNALNI
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNDDKLQVRQNLSKTNSFKELTIIRDTIFWIDFVGEGQNQNAIFARPFYEKDAFPQKLT
CCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHC
NKKYLIKNNFHGYGGKSYKCIDFKNNFYLIWIDQFSKAVWFEIFKNAGITDKSQNKYLES
CCEEEEECCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VQEPRQLSKSIEGNFDSSFVISEKDFLYGICEINNSDYLFSLNLNKNEQDIYLIKKFKNF
HHHHHHHHHHHCCCCCCEEEEECCCEEEEEEEECCCCEEEEEECCCCCCCEEHEEHHHHH
AGDLSSNTSVSLLSWIEWDSPYMPWEKNNLFFAQMDLDGEIKQLKKFSNELVNTKKNVSF
CCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCE
FQPYWISEKILVCSEDSSGWWNLLFLDVSEIESIFITKRIKRNWIEYGAPQWVSGIAFFS
ECCEECCCEEEEEECCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GTLQNLFCLAKKENSWILEQYKDLAFFKKFSTPFTAVSDFSVFEKKVVLKGFGSDFLGNL
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHCCHH
FEIDFKEKVSSDFFEEINVEHIKDCSKPESFWFKGFEDKLTHSFLYRPLVEKFRKPPLLV
EEECHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEE
RAHSGPTSCFDGSYNAEVQYWTAQGFFVAEVNYGGSSGFGKVYRERLNYKWGIVDSYDCK
EECCCCCCCCCCCCCCEEEEEEECCEEEEEEECCCCCCHHHHHHHHCCCEECCCCCCCHH
ALALELLKLNLVDSEKVVIFGNSAGGFTALNCLSYGSIFTAAICKYPVIDLKEMHYKTHR
HHHHHHHHHEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FEKDYLNSLVGDYEKNHDKYIYRSPINRINKIKKPILLFHGKKDSVISYEQTLKIQEILI
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHH
RNNKFSEAIFFENEGHGFKNIETKELVMKKSQEFLKNALNI
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]