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The map label for this gene is fdhA [H]

Identifier: 78355764

GI number: 78355764

Start: 734557

End: 736953

Strand: Direct

Name: fdhA [H]

Synonym: Dde_0717

Alternate gene names: 78355764

Gene position: 734557-736953 (Clockwise)

Preceding gene: 78355763

Following gene: 78355765

Centisome position: 19.69

GC content: 57.49

Gene sequence:

>2397_bases
ATGACCAATCACTGGATCGACCTCAAGAACAGTGACTGCATACTTATAATGGGCAGCAACGCTGCCGAAAACCACCCCAT
TTCTTTCAAATGGGTGCTTAAGGCCAGAGACGCGGGCGCCACGCTGATTCATGTGGACCCCCGCTATACGCGTACCTCGG
CGCGGTGCGACATGTACGCACCCATCCGGTCCGGTGCCGATATTCCTTTCCTCGGCGGCCTCATCAAGTACATTCTCGAT
AACAATCTCTATTTCCGCGAATACGTGGCCGAGTACACCAACGCTTCGTATATCGTGAGCGAGAAGTACAGCTTTGAAAA
CGGCTTCTTCAGCGGGTTTAATCCGGAAAAACGCAACTACGACAAGTCGCAGTGGGCGTTTGAAACCGATGCTGACGGCG
TGCCACTGCGCGACAAGACACTGCAGCACCCGCGCTGTGTGCTTAATCTGCTTAAAGAGCATTACGAGCGGTACACCGTG
GACAAGGTGGTTGATATAACCGGCACTCCGCGCGAAGACCTGCTTGCCGTGTACAAGGCGTTTGCCGCCACCGGCAAAAA
GGACAAAGCCGGCACCATCATGTATGCCATGGGCTGGACCCAGCATACCGTGGGTGTGCAGAATATCAGAGCCATGGCCA
TTATCCAGCTGCTGCTGGGCAACATCGGCGTGGCCGGCGGCGGGGTGAACGCACTGCGCGGTGAATCCAACGTGCAGGGT
TCCACCGACCAGTGTCTGCTTGCGCACATCATTCCCGGTTATCTGGGTGTGCCCAAATCGGGCTGGCCCACACTGGCCGA
TTACAACAAAGCCAACACCCCGGTCAGCAAAGACCCCATGTCGGCCAACTGGTGGCAGAACAAGCCCAAGTATGTGGCCA
GCCTGCTCAAGGCCATGTACCCCGCCGCATCGCTGGACAGCGCGTATGAATGGCTGCCCAAGGTGGATGCGCACAAGCCC
ATGACAGACTACTTCTGGCTGTCCATGTTTGAAAAGATGCACAAGGAGCAGTTCAAGGGCTTTTTCGCATGGGGCATGAA
CCCCGCCTGCGGCGGTGCCAACGCCAATAAAAACCGCGAAGCACTGGGTAAGCTGGACTGGCTGGTCAACGTCAATATCT
TTGAAAACGAGACCAGTTCGTTCTGGAAAGGGCCGGGTATGAATCCTTCCGACATCAAGACGGAAGTATTCTTTCTGCCG
TGCGCCGTCTCCATCGAAAAAGAAGGCTCGGTCACAAACTCCGGCCGCTGGATGCAGTGGCGTTATGCAGGGCCCAAGCC
CTACGCCGGCAACAAGCCTGACGGTGACATCGTATATGAACTGATGGAAAAGGTGCGCCATCTGTACGGCAAGGAAGGCG
GCGTATTCCCCGACCCCATCATGCATCTTAATCTGGACGACTGGCATACGGACCACGTCTTTGACCCGCATAAGGTGGCA
AAGCTGATCAACGGTTACTTCCTGCGTGATGTGACCATAAAGGGCAAGACTTACAAAAAAGGTCAGCAGGTGCCCAGCTT
TGCCTTTCTGCAGGATGACGGTTCCACCTGTTCGGGGAACTGGCTGTACTGCAATTCATACACGGACAAGGGCAACATGG
CCGCCCGCCGTGACAAAACCCAGACGCCTGAACAGGCAAACATCGGTCTGTATCCCAACTGGGCGTGGTGCTGGCCCGTC
AACCGCCGCATTCTGTACAACCGTGCATCGGTGGATACCAAGGGCACCCCGTGGGCACCCGGAAAAGCGGTCATCGCGTG
GAACGGCAAAGGCTGGACAGGCGACGTGCCCGACGGCGGATGGGAACCCGGAACAAAGCATCCGTTCATCATGCGCAAGC
ATGGCGCGGGGCAGATATTCGGTCCCGGACGCGAGGAAGGCCCCTTCCCCGAGCACTACGAGCCTCTGGAATGTCCGGTG
AAGGACAACCCGTTCTCGCCGCAGCTGCACAACCCCACGGCGTACACCATAGCCGGAGAAGCTGCAGCCGTGTGCGATCC
CCGGTATCCTTTTGTGGGCACCACATATCGTGTTACCGAGCACTGGCAGACCGGACTGATGACCCGTTATCAGCCCTGGC
TCATTGAAGCCGAACCGCAGCTTTTTGTGGAGATAAGCGAAGAGCTGGCCCGGCTGCGCGGCATAGAGGGCGGCGAAAAA
GTGCGTGTGTCCAGTCTGCGCGGGCAGCTGGAGTGCGTGGCCATAGTCACCAAACGCATCAAGCCCTTTGTCGTGCAGGG
CAACGACATCCACCTTGTGGGGCTGCCGTGGCATTATGGCTGGATAACCCCTAAAAACGGCGGTGATGCGGCAAACCTGC
TCACGCCGTCAGTGGGCGACCCCAATACCGGCATTCCCGAAACCAAGGCGTTCATGGTCGACGTCCGCAAGCTGTAA

Upstream 100 bases:

>100_bases
TTTTCTCAGATCTCTCGGCCTGGTGTACATAGAGCATCAGGCGCGTATCTGACACAGCGCAACTGTAGCGGCTCTGGCAG
AGTCGTTCGGACGCGGTGCG

Downstream 100 bases:

>100_bases
GGAGGCTGAAAAATGGGAAAGGCGTTCTTTGTTGATCTTACCCGCTGCACAGCCTGCCGCGGATGTCAGATAGCCTGCAA
GCAGTGGCATAAGCTGCCTG

Product: formate dehydrogenase subunit alpha, anaerobic

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MTNHWIDLKNSDCILIMGSNAAENHPISFKWVLKARDAGATLIHVDPRYTRTSARCDMYAPIRSGADIPFLGGLIKYILD
NNLYFREYVAEYTNASYIVSEKYSFENGFFSGFNPEKRNYDKSQWAFETDADGVPLRDKTLQHPRCVLNLLKEHYERYTV
DKVVDITGTPREDLLAVYKAFAATGKKDKAGTIMYAMGWTQHTVGVQNIRAMAIIQLLLGNIGVAGGGVNALRGESNVQG
STDQCLLAHIIPGYLGVPKSGWPTLADYNKANTPVSKDPMSANWWQNKPKYVASLLKAMYPAASLDSAYEWLPKVDAHKP
MTDYFWLSMFEKMHKEQFKGFFAWGMNPACGGANANKNREALGKLDWLVNVNIFENETSSFWKGPGMNPSDIKTEVFFLP
CAVSIEKEGSVTNSGRWMQWRYAGPKPYAGNKPDGDIVYELMEKVRHLYGKEGGVFPDPIMHLNLDDWHTDHVFDPHKVA
KLINGYFLRDVTIKGKTYKKGQQVPSFAFLQDDGSTCSGNWLYCNSYTDKGNMAARRDKTQTPEQANIGLYPNWAWCWPV
NRRILYNRASVDTKGTPWAPGKAVIAWNGKGWTGDVPDGGWEPGTKHPFIMRKHGAGQIFGPGREEGPFPEHYEPLECPV
KDNPFSPQLHNPTAYTIAGEAAAVCDPRYPFVGTTYRVTEHWQTGLMTRYQPWLIEAEPQLFVEISEELARLRGIEGGEK
VRVSSLRGQLECVAIVTKRIKPFVVQGNDIHLVGLPWHYGWITPKNGGDAANLLTPSVGDPNTGIPETKAFMVDVRKL

Sequences:

>Translated_798_residues
MTNHWIDLKNSDCILIMGSNAAENHPISFKWVLKARDAGATLIHVDPRYTRTSARCDMYAPIRSGADIPFLGGLIKYILD
NNLYFREYVAEYTNASYIVSEKYSFENGFFSGFNPEKRNYDKSQWAFETDADGVPLRDKTLQHPRCVLNLLKEHYERYTV
DKVVDITGTPREDLLAVYKAFAATGKKDKAGTIMYAMGWTQHTVGVQNIRAMAIIQLLLGNIGVAGGGVNALRGESNVQG
STDQCLLAHIIPGYLGVPKSGWPTLADYNKANTPVSKDPMSANWWQNKPKYVASLLKAMYPAASLDSAYEWLPKVDAHKP
MTDYFWLSMFEKMHKEQFKGFFAWGMNPACGGANANKNREALGKLDWLVNVNIFENETSSFWKGPGMNPSDIKTEVFFLP
CAVSIEKEGSVTNSGRWMQWRYAGPKPYAGNKPDGDIVYELMEKVRHLYGKEGGVFPDPIMHLNLDDWHTDHVFDPHKVA
KLINGYFLRDVTIKGKTYKKGQQVPSFAFLQDDGSTCSGNWLYCNSYTDKGNMAARRDKTQTPEQANIGLYPNWAWCWPV
NRRILYNRASVDTKGTPWAPGKAVIAWNGKGWTGDVPDGGWEPGTKHPFIMRKHGAGQIFGPGREEGPFPEHYEPLECPV
KDNPFSPQLHNPTAYTIAGEAAAVCDPRYPFVGTTYRVTEHWQTGLMTRYQPWLIEAEPQLFVEISEELARLRGIEGGEK
VRVSSLRGQLECVAIVTKRIKPFVVQGNDIHLVGLPWHYGWITPKNGGDAANLLTPSVGDPNTGIPETKAFMVDVRKL
>Mature_797_residues
TNHWIDLKNSDCILIMGSNAAENHPISFKWVLKARDAGATLIHVDPRYTRTSARCDMYAPIRSGADIPFLGGLIKYILDN
NLYFREYVAEYTNASYIVSEKYSFENGFFSGFNPEKRNYDKSQWAFETDADGVPLRDKTLQHPRCVLNLLKEHYERYTVD
KVVDITGTPREDLLAVYKAFAATGKKDKAGTIMYAMGWTQHTVGVQNIRAMAIIQLLLGNIGVAGGGVNALRGESNVQGS
TDQCLLAHIIPGYLGVPKSGWPTLADYNKANTPVSKDPMSANWWQNKPKYVASLLKAMYPAASLDSAYEWLPKVDAHKPM
TDYFWLSMFEKMHKEQFKGFFAWGMNPACGGANANKNREALGKLDWLVNVNIFENETSSFWKGPGMNPSDIKTEVFFLPC
AVSIEKEGSVTNSGRWMQWRYAGPKPYAGNKPDGDIVYELMEKVRHLYGKEGGVFPDPIMHLNLDDWHTDHVFDPHKVAK
LINGYFLRDVTIKGKTYKKGQQVPSFAFLQDDGSTCSGNWLYCNSYTDKGNMAARRDKTQTPEQANIGLYPNWAWCWPVN
RRILYNRASVDTKGTPWAPGKAVIAWNGKGWTGDVPDGGWEPGTKHPFIMRKHGAGQIFGPGREEGPFPEHYEPLECPVK
DNPFSPQLHNPTAYTIAGEAAAVCDPRYPFVGTTYRVTEHWQTGLMTRYQPWLIEAEPQLFVEISEELARLRGIEGGEKV
RVSSLRGQLECVAIVTKRIKPFVVQGNDIHLVGLPWHYGWITPKNGGDAANLLTPSVGDPNTGIPETKAFMVDVRKL

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=815, Percent_Identity=45.8895705521472, Blast_Score=711, Evalue=0.0,
Organism=Escherichia coli, GI3868720, Length=815, Percent_Identity=45.2760736196319, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=445, Percent_Identity=23.8202247191011, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 89567; Mature: 89435

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHWIDLKNSDCILIMGSNAAENHPISFKWVLKARDAGATLIHVDPRYTRTSARCDMYA
CCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEC
PIRSGADIPFLGGLIKYILDNNLYFREYVAEYTNASYIVSEKYSFENGFFSGFNPEKRNY
HHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHCCC
DKSQWAFETDADGVPLRDKTLQHPRCVLNLLKEHYERYTVDKVVDITGTPREDLLAVYKA
CHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHH
FAATGKKDKAGTIMYAMGWTQHTVGVQNIRAMAIIQLLLGNIGVAGGGVNALRGESNVQG
HHHCCCCCCCCEEEEEECCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCC
STDQCLLAHIIPGYLGVPKSGWPTLADYNKANTPVSKDPMSANWWQNKPKYVASLLKAMY
CCHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PAASLDSAYEWLPKVDAHKPMTDYFWLSMFEKMHKEQFKGFFAWGMNPACGGANANKNRE
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCHH
ALGKLDWLVNVNIFENETSSFWKGPGMNPSDIKTEVFFLPCAVSIEKEGSVTNSGRWMQW
HHCCEEEEEEEEEEECCCCHHCCCCCCCHHHCCEEEEEEEEEEEEECCCCCCCCCCEEEE
RYAGPKPYAGNKPDGDIVYELMEKVRHLYGKEGGVFPDPIMHLNLDDWHTDHVFDPHKVA
EECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
KLINGYFLRDVTIKGKTYKKGQQVPSFAFLQDDGSTCSGNWLYCNSYTDKGNMAARRDKT
HHHCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCC
QTPEQANIGLYPNWAWCWPVNRRILYNRASVDTKGTPWAPGKAVIAWNGKGWTGDVPDGG
CCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
WEPGTKHPFIMRKHGAGQIFGPGREEGPFPEHYEPLECPVKDNPFSPQLHNPTAYTIAGE
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
AAAVCDPRYPFVGTTYRVTEHWQTGLMTRYQPWLIEAEPQLFVEISEELARLRGIEGGEK
EEEEECCCCCCCCCEEEEHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCE
VRVSSLRGQLECVAIVTKRIKPFVVQGNDIHLVGLPWHYGWITPKNGGDAANLLTPSVGD
EEEEHHCCCCEEEEEHHHCCCEEEEECCEEEEEECCCCCCEECCCCCCCCHHCCCCCCCC
PNTGIPETKAFMVDVRKL
CCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TNHWIDLKNSDCILIMGSNAAENHPISFKWVLKARDAGATLIHVDPRYTRTSARCDMYA
CCCEEEECCCCEEEEECCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEC
PIRSGADIPFLGGLIKYILDNNLYFREYVAEYTNASYIVSEKYSFENGFFSGFNPEKRNY
HHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHCCC
DKSQWAFETDADGVPLRDKTLQHPRCVLNLLKEHYERYTVDKVVDITGTPREDLLAVYKA
CHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHH
FAATGKKDKAGTIMYAMGWTQHTVGVQNIRAMAIIQLLLGNIGVAGGGVNALRGESNVQG
HHHCCCCCCCCEEEEEECCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCC
STDQCLLAHIIPGYLGVPKSGWPTLADYNKANTPVSKDPMSANWWQNKPKYVASLLKAMY
CCHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PAASLDSAYEWLPKVDAHKPMTDYFWLSMFEKMHKEQFKGFFAWGMNPACGGANANKNRE
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCHH
ALGKLDWLVNVNIFENETSSFWKGPGMNPSDIKTEVFFLPCAVSIEKEGSVTNSGRWMQW
HHCCEEEEEEEEEEECCCCHHCCCCCCCHHHCCEEEEEEEEEEEEECCCCCCCCCCEEEE
RYAGPKPYAGNKPDGDIVYELMEKVRHLYGKEGGVFPDPIMHLNLDDWHTDHVFDPHKVA
EECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
KLINGYFLRDVTIKGKTYKKGQQVPSFAFLQDDGSTCSGNWLYCNSYTDKGNMAARRDKT
HHHCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCC
QTPEQANIGLYPNWAWCWPVNRRILYNRASVDTKGTPWAPGKAVIAWNGKGWTGDVPDGG
CCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
WEPGTKHPFIMRKHGAGQIFGPGREEGPFPEHYEPLECPVKDNPFSPQLHNPTAYTIAGE
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
AAAVCDPRYPFVGTTYRVTEHWQTGLMTRYQPWLIEAEPQLFVEISEELARLRGIEGGEK
EEEEECCCCCCCCCEEEEHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCE
VRVSSLRGQLECVAIVTKRIKPFVVQGNDIHLVGLPWHYGWITPKNGGDAANLLTPSVGD
EEEEHHCCCCEEEEEHHHCCCEEEEECCEEEEEECCCCCCEECCCCCCCCHHCCCCCCCC
PNTGIPETKAFMVDVRKL
CCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA