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The map label for this gene is fdhA [H]

Identifier: 78355763

GI number: 78355763

Start: 733909

End: 734508

Strand: Direct

Name: fdhA [H]

Synonym: Dde_0716

Alternate gene names: 78355763

Gene position: 733909-734508 (Clockwise)

Preceding gene: 78355762

Following gene: 78355764

Centisome position: 19.67

GC content: 59.33

Gene sequence:

>600_bases
ATGCGGCATCACAAAGGAGGCATGATGACAGTATCACGGAGAACTTTTATCAAGGCGGCAGCAGGTGCGGCCACCGCCAC
GGCATTTGCGGGGCTGGGGGTCAGCCTTTCGCCGGGTGTGGCGCGGGCACAGCTGCTCAAGCTTGAATGGGCACGGCAGA
GCACATCGGTGTGCTGTTACTGTGCGGTGGGCTGCGGCCTTATCGTCCATACTTCCAAAGACGGACAGGGACGCGCCATC
AACGTCGAGGGCGATCCCGACCATCCCATCAACGAAGGAGCCCTGTGCGCCAAGGGTGCTTCCATCTGGCAGCTGGCAGA
AAACGACCGCCGCCCCGCAAGCCCCATGTACCGCGCGCCCTACAGCGACCACTGGCAGCCTGTATCGTGGGAGTGGGCAC
TGGAAAACATAGCTGCCCGCATCAAAAAGACCCGCGACGAATCTTTTATCACCCGCAATGAAAAAGGCGAACAGGTTAAC
AGAACCGACGTCATCGCCTCCGCCGGTTCCGCGGCGCTCGATAACGAAGAATGCTGGGTTTACCAGTCTTTTCTCAGATC
TCTCGGCCTGGTGTACATAGAGCATCAGGCGCGTATCTGA

Upstream 100 bases:

>100_bases
GGCTGCAGGGGGGTGTCGGGCGTGCAGCGTCCCGTTGCGCGGCATCTTTACGGATTTGCGCTGCAGGTGCGGCTGGGACG
CGAAATCAGAGGGCGATGAC

Downstream 100 bases:

>100_bases
CACAGCGCAACTGTAGCGGCTCTGGCAGAGTCGTTCGGACGCGGTGCGATGACCAATCACTGGATCGACCTCAAGAACAG
TGACTGCATACTTATAATGG

Product: formate dehydrogenase

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRHHKGGMMTVSRRTFIKAAAGAATATAFAGLGVSLSPGVARAQLLKLEWARQSTSVCCYCAVGCGLIVHTSKDGQGRAI
NVEGDPDHPINEGALCAKGASIWQLAENDRRPASPMYRAPYSDHWQPVSWEWALENIAARIKKTRDESFITRNEKGEQVN
RTDVIASAGSAALDNEECWVYQSFLRSLGLVYIEHQARI

Sequences:

>Translated_199_residues
MRHHKGGMMTVSRRTFIKAAAGAATATAFAGLGVSLSPGVARAQLLKLEWARQSTSVCCYCAVGCGLIVHTSKDGQGRAI
NVEGDPDHPINEGALCAKGASIWQLAENDRRPASPMYRAPYSDHWQPVSWEWALENIAARIKKTRDESFITRNEKGEQVN
RTDVIASAGSAALDNEECWVYQSFLRSLGLVYIEHQARI
>Mature_199_residues
MRHHKGGMMTVSRRTFIKAAAGAATATAFAGLGVSLSPGVARAQLLKLEWARQSTSVCCYCAVGCGLIVHTSKDGQGRAI
NVEGDPDHPINEGALCAKGASIWQLAENDRRPASPMYRAPYSDHWQPVSWEWALENIAARIKKTRDESFITRNEKGEQVN
RTDVIASAGSAALDNEECWVYQSFLRSLGLVYIEHQARI

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868720, Length=195, Percent_Identity=41.025641025641, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI3868719, Length=198, Percent_Identity=41.9191919191919, Blast_Score=156, Evalue=7e-40,
Organism=Escherichia coli, GI1788534, Length=144, Percent_Identity=35.4166666666667, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 21802; Mature: 21802

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHHKGGMMTVSRRTFIKAAAGAATATAFAGLGVSLSPGVARAQLLKLEWARQSTSVCCY
CCCCCCCEEEEHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
CAVGCGLIVHTSKDGQGRAINVEGDPDHPINEGALCAKGASIWQLAENDRRPASPMYRAP
EECCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCC
YSDHWQPVSWEWALENIAARIKKTRDESFITRNEKGEQVNRTDVIASAGSAALDNEECWV
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHEECCCCCCCCCHHHHHHCCCCCCCCCCHHHH
YQSFLRSLGLVYIEHQARI
HHHHHHHCCEEEEECCCCC
>Mature Secondary Structure
MRHHKGGMMTVSRRTFIKAAAGAATATAFAGLGVSLSPGVARAQLLKLEWARQSTSVCCY
CCCCCCCEEEEHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
CAVGCGLIVHTSKDGQGRAINVEGDPDHPINEGALCAKGASIWQLAENDRRPASPMYRAP
EECCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCC
YSDHWQPVSWEWALENIAARIKKTRDESFITRNEKGEQVNRTDVIASAGSAALDNEECWV
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHEECCCCCCCCCHHHHHHCCCCCCCCCCHHHH
YQSFLRSLGLVYIEHQARI
HHHHHHHCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA