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The map label for this gene is eriC [C]

Identifier: 78355357

GI number: 78355357

Start: 298670

End: 300517

Strand: Direct

Name: eriC [C]

Synonym: Dde_0310

Alternate gene names: 78355357

Gene position: 298670-300517 (Clockwise)

Preceding gene: 78355356

Following gene: 78355359

Centisome position: 8.01

GC content: 61.04

Gene sequence:

>1848_bases
ATGACAACGGATGATGACGGCGGACGGAACGGAAGCCGCGATGACGGGACCTGCCCCGTACCGTCCCGGCCTTTTTCGCT
GCGCAGTCTGCAGCACGGCTGGCGGACTTTGCGGTCGGGGCGTCTTGCCAAGCTGGACAGCCATCTGCCCATGCTGCTTA
TGGCTGTGCTGGTGGGGGTGCTGGGCGGATACGGCGCGGTGCTGTTCAAGTTTGTCATCAAAGGTGTGCAGTTTCTTTTT
TACGGAAACACTGCGGACTTTCTTGAATTTCATGACTCGGTGCCGTACTGGGCGGTCATTGCCGCTCCTGCCGCGGGCGG
GCTGGCGGTCGGCTATCTTGTTTCGCGTTTTGCCCGCGAGGCGCGGGGGCACGGCGTGCCGGAGGTAATGGAGGCCATTG
CCCTGCATGACGGGCGTATCCGCAAGCGGGTGGCGCTGGTCAAGATTTTTGCCTCGGCCATCAGCATAAGTTCCGGCGGC
TCGGTGGGGCGCGAAGGGCCCATCGTGCAGATAGGGTCGGGCATAGGGTCCACCGTGGGACAGATGCTTAAAGTGGGCAG
GCCCCAGCGGCGTACGCTGGTGGGCTGCGGTGCTGCCGCGGGCATCGCCGCCACGTTCAACGCGCCGGTGGCCGGTGTGC
TGTTCGCCCTTGAACTGCTGCTGGGTGATTTCGGTCTGGCGGCGTTTTCTCCCGTGGTGCTTTCATCCGTGGTTGCCACC
ACCATTTCACGCCATTATTTCGGCGACTTTCCCGCGTTTGTGGTGCCCGGCTACGAAGTTGCCTCGCTGTGGGAGTACGG
CATCTATCCTTTTCTGGGCATTGTGTGCGGCGCGGTGGCGGTGATTTTTGTGACGGTGCTGTACCGTACTGAAGACCTGT
GCGAGGCAGTGCGCCTGCCGGACCCGCTCAAAGCCTGTCTGGGCGGAGCCGCCGTGGGGTGTATGCTGTTGTGGTTTCCT
CATGTTTTCGGTGTGGGATACGGCGGCATCAACCTTGCCCTGCAGAACGGTCTGGGGTGGCAGATGATGCTGCTGCTTGT
GGGGGTTAAAATCATCGCCACGTCTGTAACCATCGGCAGCGGCGGGTCCGGCGGGGTGTTCGCTCCTTCGCTTTTCATAG
GTTCCATGACCGGTGGTTTTTTCGGCTGGGCCGCGGGGCAGCTTTTTCCCGGTATAACGGCATTGCCGGGCGCATATGCG
CTGGTCGCCATGGGCGGTCTGGTGGCCGGCACCACCCACGCTCCCATTACAGCCATTCTGATTATTTTTGAACTGACAGG
CGACTACCAGATAATTCTGCCGCTTATGGTCACCTGCATACTGGCCACCGTGACGGCTTCCACTCTGAAAGACGGCTCCA
TTTATACCATAAAGCTGCTGCGCCGCGGGGTGGATATTGCCGGCGGCATGGAGCAGAACCTGTTACGCAGTCTCAAGGTG
GGCGAATTCATGCGGGCGGACCCGCCCACCATATGGGAAGGCACGCCGCTGCATGACGTGATTCTGGCTTTTCGCCAGCG
TGATGTCTCGTACCTGCATGTGGTGGACAGGGAGGGCGGACTGAAGGGCATTATTTCGTTCCGCGACCTGCGTGCAGTGC
TGGCGGATGAATATCCGGCGCGCCTTGTCATTGCCGGCGACATAGCAACCACGCGTCTTGTCACGGTGACGGAGGGCGAT
TCCATACAATGCGCGCTGGGGCGGATGAGCCGCAGCGGCATAGCCCAGCTGCCGGTTGTGGAACTGGGGGATGCCCGCCG
GTTGAAAGGCATACTGAGAGAAAAAGATGTCATTCATGCCTATGATATGGCCGTGGTGCGGCGTCAGATGGAGCACGGTG
CCCCCTAG

Upstream 100 bases:

>100_bases
TTTTGCCGGCGTGCGGCTTGGCATACGCTGTTGTCCGCGTTAGAATGCGGCAGTGTGTCCGGTGTTGTCCTGCCGGGCAG
ACAGATGCAGGGAGTGCGCT

Downstream 100 bases:

>100_bases
TGCTCCGCCGGACGGTCTCTGCGTGGCGGCTGCCGCGCGGGTGCCGCTTGCGCGACCGGAATTTTTGCGCCTGTCGTTTT
TAACGTAACGTGCCGAAATG

Product: hypothetical protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MTTDDDGGRNGSRDDGTCPVPSRPFSLRSLQHGWRTLRSGRLAKLDSHLPMLLMAVLVGVLGGYGAVLFKFVIKGVQFLF
YGNTADFLEFHDSVPYWAVIAAPAAGGLAVGYLVSRFAREARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGG
SVGREGPIVQIGSGIGSTVGQMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGLAAFSPVVLSSVVAT
TISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIFVTVLYRTEDLCEAVRLPDPLKACLGGAAVGCMLLWFP
HVFGVGYGGINLALQNGLGWQMMLLLVGVKIIATSVTIGSGGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYA
LVAMGGLVAGTTHAPITAILIIFELTGDYQIILPLMVTCILATVTASTLKDGSIYTIKLLRRGVDIAGGMEQNLLRSLKV
GEFMRADPPTIWEGTPLHDVILAFRQRDVSYLHVVDREGGLKGIISFRDLRAVLADEYPARLVIAGDIATTRLVTVTEGD
SIQCALGRMSRSGIAQLPVVELGDARRLKGILREKDVIHAYDMAVVRRQMEHGAP

Sequences:

>Translated_615_residues
MTTDDDGGRNGSRDDGTCPVPSRPFSLRSLQHGWRTLRSGRLAKLDSHLPMLLMAVLVGVLGGYGAVLFKFVIKGVQFLF
YGNTADFLEFHDSVPYWAVIAAPAAGGLAVGYLVSRFAREARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGG
SVGREGPIVQIGSGIGSTVGQMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGLAAFSPVVLSSVVAT
TISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIFVTVLYRTEDLCEAVRLPDPLKACLGGAAVGCMLLWFP
HVFGVGYGGINLALQNGLGWQMMLLLVGVKIIATSVTIGSGGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYA
LVAMGGLVAGTTHAPITAILIIFELTGDYQIILPLMVTCILATVTASTLKDGSIYTIKLLRRGVDIAGGMEQNLLRSLKV
GEFMRADPPTIWEGTPLHDVILAFRQRDVSYLHVVDREGGLKGIISFRDLRAVLADEYPARLVIAGDIATTRLVTVTEGD
SIQCALGRMSRSGIAQLPVVELGDARRLKGILREKDVIHAYDMAVVRRQMEHGAP
>Mature_614_residues
TTDDDGGRNGSRDDGTCPVPSRPFSLRSLQHGWRTLRSGRLAKLDSHLPMLLMAVLVGVLGGYGAVLFKFVIKGVQFLFY
GNTADFLEFHDSVPYWAVIAAPAAGGLAVGYLVSRFAREARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGGS
VGREGPIVQIGSGIGSTVGQMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGLAAFSPVVLSSVVATT
ISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIFVTVLYRTEDLCEAVRLPDPLKACLGGAAVGCMLLWFPH
VFGVGYGGINLALQNGLGWQMMLLLVGVKIIATSVTIGSGGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYAL
VAMGGLVAGTTHAPITAILIIFELTGDYQIILPLMVTCILATVTASTLKDGSIYTIKLLRRGVDIAGGMEQNLLRSLKVG
EFMRADPPTIWEGTPLHDVILAFRQRDVSYLHVVDREGGLKGIISFRDLRAVLADEYPARLVIAGDIATTRLVTVTEGDS
IQCALGRMSRSGIAQLPVVELGDARRLKGILREKDVIHAYDMAVVRRQMEHGAP

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Homo sapiens, GI189217923, Length=457, Percent_Identity=24.72647702407, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI189217921, Length=457, Percent_Identity=24.72647702407, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4557473, Length=458, Percent_Identity=26.2008733624454, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI1786350, Length=446, Percent_Identity=34.7533632286996, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI87081943, Length=411, Percent_Identity=32.1167883211679, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71996455, Length=415, Percent_Identity=23.855421686747, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996452, Length=415, Percent_Identity=23.855421686747, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985148, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71985141, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24665008, Length=533, Percent_Identity=24.577861163227, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551566, Length=519, Percent_Identity=23.8921001926782, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 65117; Mature: 64986

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDDDGGRNGSRDDGTCPVPSRPFSLRSLQHGWRTLRSGRLAKLDSHLPMLLMAVLVGV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHH
LGGYGAVLFKFVIKGVQFLFYGNTADFLEFHDSVPYWAVIAAPAAGGLAVGYLVSRFARE
HHHHHHHHHHHHHHHHHEEEECCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
ARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGGSVGREGPIVQIGSGIGSTVG
HCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHH
QMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGLAAFSPVVLSSVVAT
HHHHCCCCCHHEEEECCCHHCHHEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIFVTVLYRTEDLCEAVRLP
HHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPLKACLGGAAVGCMLLWFPHVFGVGYGGINLALQNGLGWQMMLLLVGVKIIATSVTIGS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEECC
GGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYALVAMGGLVAGTTHAPITAIL
CCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCCCCCCHHHHHH
IIFELTGDYQIILPLMVTCILATVTASTLKDGSIYTIKLLRRGVDIAGGMEQNLLRSLKV
EEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCHHHHHHHHHHH
GEFMRADPPTIWEGTPLHDVILAFRQRDVSYLHVVDREGGLKGIISFRDLRAVLADEYPA
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
RLVIAGDIATTRLVTVTEGDSIQCALGRMSRSGIAQLPVVELGDARRLKGILREKDVIHA
EEEEEECCCEEEEEEEECCCCEEEHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
YDMAVVRRQMEHGAP
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTDDDGGRNGSRDDGTCPVPSRPFSLRSLQHGWRTLRSGRLAKLDSHLPMLLMAVLVGV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHH
LGGYGAVLFKFVIKGVQFLFYGNTADFLEFHDSVPYWAVIAAPAAGGLAVGYLVSRFARE
HHHHHHHHHHHHHHHHHEEEECCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
ARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGGSVGREGPIVQIGSGIGSTVG
HCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHH
QMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGLAAFSPVVLSSVVAT
HHHHCCCCCHHEEEECCCHHCHHEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIFVTVLYRTEDLCEAVRLP
HHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPLKACLGGAAVGCMLLWFPHVFGVGYGGINLALQNGLGWQMMLLLVGVKIIATSVTIGS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEECC
GGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYALVAMGGLVAGTTHAPITAIL
CCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCCCCCCHHHHHH
IIFELTGDYQIILPLMVTCILATVTASTLKDGSIYTIKLLRRGVDIAGGMEQNLLRSLKV
EEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCHHHHHHHHHHH
GEFMRADPPTIWEGTPLHDVILAFRQRDVSYLHVVDREGGLKGIISFRDLRAVLADEYPA
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
RLVIAGDIATTRLVTVTEGDSIQCALGRMSRSGIAQLPVVELGDARRLKGILREKDVIHA
EEEEEECCCEEEEEEEECCCCEEEHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
YDMAVVRRQMEHGAP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]