Click here to switch to the map view.

The map label for this gene is fumC

Identifier: 78065675

GI number: 78065675

Start: 1138565

End: 1139959

Strand: Reverse

Name: fumC

Synonym: Bcep18194_A4203

Alternate gene names: 78065675

Gene position: 1139959-1138565 (Counterclockwise)

Preceding gene: 78065676

Following gene: 78065673

Centisome position: 30.86

GC content: 67.03

Gene sequence:

>1395_bases
ATGAACGAAGCAGTTCGGATGGAACGCGATACGTTTGGCGAGATCGCCGTGCCGGCCGACCGGCTCTGGGGCGCGCAGAC
CGAGCGCTCGCTGCAGAATTTCCGGATCTCGACCGAGAAGCAGTCGCCCGAGCTGATCCACGCGCTCGCGATCGTCAAGC
GCGCCGCAGCGGCCGTGAACCAGTCGCTCGGCGTGCTGGCCGACGACAAGGCGCGCGCGATCATCGACGCGGCCGACGAG
ATCATCGCCGGCAAGCATCCGCGTGAATTCCCGCTCGCCGTGTGGCAGACGGGCTCCGGCACGCAGACCAACATGAACCT
CAACGAGGTGATCGCGAATCGCGCGAGCGAACTGATGGGCGGCGAGCGCGGCGAAGCGCGCAAGGTTCATCCGAACGACG
ACGTCAACCGCGGCCAGTCGTCGAACGACGTGTTCCCGACCGCGATGCACGTCGCGGCCGCGTACGCGATCGTCAACCAC
CTGCTGCCGGCGCTGCGTACGCTGCGCACGACACTCGACGCGAAGTCGAAGGCGTTCGCGGACATCGTGAAGATCGGCCG
CACGCACCTGCAGGACGCGACGCCGCTCACGCTCGGCCAGGAGTTTTCCGGCTACGTCGCGCAGCTCGACCAGAGCATCC
GTCACGTCGAATCTGCGCTGCCGCACCTGTACGAACTCGCGCTCGGCGGCACGGCGGTCGGCACGGGGCTGAACGCGCAT
CCGGAGTTCGCGGTGCGCGTCGCCGATGAAATCGGCCGGCTCGCGAAGCTGCCGTTCGTGACGGCGCCGAGCAAGTTCGA
GGTGATGGCGGCCGCCGACGCGCTGGTGTTCGCGCACGGCGCGCTGAAGACGGTCGCAGCCGGCCTGATGAAGATCGCGA
ACGACGTTCGCTGGCTCGCGAGCGGGCCGCGCTGCGGGCTCGGCGAGCTGTCGATTCCCGAGAACGAGCCGGGCAGCTCG
ATCATGCCGGGCAAGGTGAACCCGACGCAGTCCGAAGCCGTGACGATGCTGTGCTGCCAGGTGTTCGGCAACGACGTCGC
GGTCAACGTCGGCGGCGCGAGCGGCAATTTCGAGCTGAACGTGTTCCGGCCGATGATCGCGCACAACGTGCTGCAATCGG
TGCGGCTGCTCGCCGATGGCGCACAGAGCTTCAACGATCACTGCGCGGTGGGCATCGAGCCGAACCGCTCGCGGATCGAC
CTGCTGCTGAACGAATCGCTGATGCTCGTGACGGCGCTCAATCCGCACATCGGCTACGACAAGTCGGCGCAGATCGCGAA
GAAGGCGCACAAGGAAGGCACGACGCTGAAGGCGGCCGCGCTCGCGCTCGGCTACCTGACCGAGGCGGAATTCGATGCGT
GGGTACGACCCGAACAGATGATCGGGTCGCAGTAA

Upstream 100 bases:

>100_bases
AGACGCCGCGCGAGCGGCGCGACTGCCTCACGATACGTCTGATTACGTCTGATGTCGCGCGACCACGCGCGGCCTTTCCC
CTTTCCTGGAGGAGTGGATC

Downstream 100 bases:

>100_bases
CGGCAGGACGACGGGCGCGGCGCGATGCGCGGCGCCCGCAGCGGTCAGACCGCGCCCTTCGCGACCTCTTCCGGTTTCAT
CTCGACGATCTTGTCGAGCG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKARAIIDAADE
IIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNH
LLPALRTLRTTLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQSIRHVESALPHLYELALGGTAVGTGLNAH
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRID
LLLNESLMLVTALNPHIGYDKSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGSQ

Sequences:

>Translated_464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKARAIIDAADE
IIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNH
LLPALRTLRTTLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQSIRHVESALPHLYELALGGTAVGTGLNAH
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRID
LLLNESLMLVTALNPHIGYDKSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGSQ
>Mature_464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKARAIIDAADE
IIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNH
LLPALRTLRTTLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQSIRHVESALPHLYELALGGTAVGTGLNAH
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRID
LLLNESLMLVTALNPHIGYDKSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGSQ

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=464, Percent_Identity=62.2844827586207, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=50, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=76.0348583877996, Blast_Score=724, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=455, Percent_Identity=40, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=63.2829373650108, Blast_Score=595, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=66.2576687116564, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=58.6206896551724, Blast_Score=558, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640179, Length=467, Percent_Identity=60.5995717344754, Blast_Score=587, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24640177, Length=467, Percent_Identity=60.5995717344754, Blast_Score=587, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=60.1731601731602, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=58.8362068965517, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.6997840172786, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49734; Mature: 49734

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVN
CCCCHHCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QSLGVLADDKARAIIDAADEIIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELMG
HCCCCEECCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNHLLPALRTLRTTLDAKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQSIRHVESALPHLYELALGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLA
CHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRIDLLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCCC
KSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGSQ
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCHHHHCCCC
>Mature Secondary Structure
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVN
CCCCHHCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QSLGVLADDKARAIIDAADEIIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELMG
HCCCCEECCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNHLLPALRTLRTTLDAKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQSIRHVESALPHLYELALGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLA
CHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRIDLLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCCC
KSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGSQ
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]