Click here to switch to the map view.

The map label for this gene is rmlA1 [H]

Identifier: 78065444

GI number: 78065444

Start: 891520

End: 892413

Strand: Direct

Name: rmlA1 [H]

Synonym: Bcep18194_A3970

Alternate gene names: 78065444

Gene position: 891520-892413 (Clockwise)

Preceding gene: 78065443

Following gene: 78065445

Centisome position: 24.13

GC content: 62.3

Gene sequence:

>894_bases
ATGGCACGCAAAGGCATCATTCTCGCCGGCGGTTCAGGCACACGGCTCTATCCGATCACGCATGCAGTATCGAAGCAACT
GCTGCCGGTGTACGACAAGCCGATGATCTACTATCCGCTGTCGACGCTGATGATTGCAGGCATCCGGGACGTGCTGATCA
TCTCGACGCCGCAGGACACCCCGCGCTTCGAGTCGATGCTCGGCGACGGCGGCCAGTGGGGGATGAATATCCGGTATGCG
ACACAGCCGTCGCCGGACGGGCTTGCGCAAGCGTTCGTCATCGGCCGGGACTTCGTTGGCAACGAGCCGTCGGCGCTCAT
CCTCGGCGACAACATTTTCTACGGGCACGATCTCGCGAAGCAGCTCGAGCGGGCCAGCGCGAAGGATGCGGGCGCGACCG
TATTTGCGTATCACGTTCAGGACCCTGAGCGGTATGGCGTGGTCGAGTTCGACCGCGAATTCCGCGCGATATCGATTGAA
GAGAAGCCGGCAAAGCCGCGTTCGAGCTATGCGGTCACGGGGCTGTATTTCTACGACACGCAGGTTTGCGACATCGCAGC
CGACATCAAGCCGTCGGCGCGCGGCGAGCTCGAGATCACCGATGTCAATTCGCGCTACCTGGCGGCGGGCCAACTCGACG
TCGAGCTCATGGGGCGCGGTTATGCGTGGCTCGATACGGGTACGCACGACTCCTTGATCGAGGCGGCGACGTTCATCGCG
ACGCTGCAGAAGCGTCAGGGGCTCATGGTCGCGTGCCCCGAAGAGATCGCGTACCGCCGCAACTGGATCGACGCGGAGCA
GGTGCTGAAACTGGCACAGCCGCTCGCGAAGAACGCCTACGGGCTGTATCTCCGGAACCTACTCACCCATCAGGTCGCAT
GGCAATCCACGTAA

Upstream 100 bases:

>100_bases
GGTATCTCGACAACCAGGCGTGGTCGGACGAGGTGGCTTCGGGCGAATACCGCAAGTGGGTCGAGACCAATTACGCAGCG
CGCGTTTGACAGGAGAGGCG

Downstream 100 bases:

>100_bases
CGGCAACGGCACTGCCCGAAGTCAAGCTTATCGAGCCGAAGGTCTTTGGCGACGCGCGCGGGTATTTCTACGAGAGCTTC
AACGCGCGCGAGTTTGCGGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGGQWGMNIRYA
TQPSPDGLAQAFVIGRDFVGNEPSALILGDNIFYGHDLAKQLERASAKDAGATVFAYHVQDPERYGVVEFDREFRAISIE
EKPAKPRSSYAVTGLYFYDTQVCDIAADIKPSARGELEITDVNSRYLAAGQLDVELMGRGYAWLDTGTHDSLIEAATFIA
TLQKRQGLMVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGLYLRNLLTHQVAWQST

Sequences:

>Translated_297_residues
MARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGGQWGMNIRYA
TQPSPDGLAQAFVIGRDFVGNEPSALILGDNIFYGHDLAKQLERASAKDAGATVFAYHVQDPERYGVVEFDREFRAISIE
EKPAKPRSSYAVTGLYFYDTQVCDIAADIKPSARGELEITDVNSRYLAAGQLDVELMGRGYAWLDTGTHDSLIEAATFIA
TLQKRQGLMVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGLYLRNLLTHQVAWQST
>Mature_296_residues
ARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGGQWGMNIRYAT
QPSPDGLAQAFVIGRDFVGNEPSALILGDNIFYGHDLAKQLERASAKDAGATVFAYHVQDPERYGVVEFDREFRAISIEE
KPAKPRSSYAVTGLYFYDTQVCDIAADIKPSARGELEITDVNSRYLAAGQLDVELMGRGYAWLDTGTHDSLIEAATFIAT
LQKRQGLMVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGLYLRNLLTHQVAWQST

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=72.280701754386, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=64.5614035087719, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1787488, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=191, Percent_Identity=24.0837696335079, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=248, Percent_Identity=26.6129032258064, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355443, Length=246, Percent_Identity=22.7642276422764, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644084, Length=246, Percent_Identity=22.7642276422764, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32914; Mature: 32783

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCCEEEECCCCCEEEEEHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFESMLGDGGQWGMNIRYATQPSPDGLAQAFVIGRDFVGNEPSALILGDNIFYGHDLAK
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHEECCCCCCCCCCEEEEECCEEECHHHHH
QLERASAKDAGATVFAYHVQDPERYGVVEFDREFRAISIEEKPAKPRSSYAVTGLYFYDT
HHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEECC
QVCDIAADIKPSARGELEITDVNSRYLAAGQLDVELMGRGYAWLDTGTHDSLIEAATFIA
EEEEEEECCCCCCCCEEEEEECCCEEEEECCEEEEEECCCEEEEECCCCHHHHHHHHHHH
TLQKRQGLMVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGLYLRNLLTHQVAWQST
HHHHHCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCEEEECCCCCEEEEEHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFESMLGDGGQWGMNIRYATQPSPDGLAQAFVIGRDFVGNEPSALILGDNIFYGHDLAK
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHEECCCCCCCCCCEEEEECCEEECHHHHH
QLERASAKDAGATVFAYHVQDPERYGVVEFDREFRAISIEEKPAKPRSSYAVTGLYFYDT
HHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEECC
QVCDIAADIKPSARGELEITDVNSRYLAAGQLDVELMGRGYAWLDTGTHDSLIEAATFIA
EEEEEEECCCCCCCCEEEEEECCCEEEEECCEEEEEECCCEEEEECCCCHHHHHHHHHHH
TLQKRQGLMVACPEEIAYRRNWIDAEQVLKLAQPLAKNAYGLYLRNLLTHQVAWQST
HHHHHCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]