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The map label for this gene is thiD [H]

Identifier: 78065433

GI number: 78065433

Start: 881520

End: 882386

Strand: Reverse

Name: thiD [H]

Synonym: Bcep18194_A3959

Alternate gene names: 78065433

Gene position: 882386-881520 (Counterclockwise)

Preceding gene: 78065442

Following gene: 78065432

Centisome position: 23.89

GC content: 68.63

Gene sequence:

>867_bases
ATGTCCAGCAACGCCCCTCCGATCGTCCTCACCTTCGGCCTGTCCGACCCCACCGGCGGTTCTGGCATTCAAGCCGATCT
GTTGACCCTGGCGAGCATGGGCTGTCACGGTGTGTCCGTCCTGACGGGCTACACCGTGCGTGACTCGGCCGCCTGCGACG
AAGTGACCGGCCTCGATCCCGACGTGGTCGCCGCCCAGGCGCGCATGCTGCTCGAAGACATGCCGGTTGCGGCGTTCAAG
ATCGGCGCGGCGACGCGCGCGGAAGTCGTGAGCGCCATCGCCGAGGTCGTCGCCGACTACGACGGTGTGCCGCTCGTGCT
CGCACCGGACTTCACGCTCGACGACGAACACGTGCTCGCAGCCGACGATCTGCGCGAATCGATCGCCGACCTGCTGGCGC
CGCAAACCACGCTGCTGGTCGCCGACTACGCCACGCTGATCGCGCTCGCGCAGCCGGACGGTGACGCCGAGGCGCCGAAT
CTCGACGCGGCCGTCTCGCACCTGCTGTCGCAGGGCTGCGAGTACATCCTGTCGTCCGAAACGGGCTCGCACCGGCTCGT
CAACACGCTGTACGGCGAGGAAGGCCAGCTCCGCGAAGACATGTGGGATCGCTCGCCGCACCGGCTGATGGGCATCACCG
ACACGCTGGGCGCGGCCATCGCGGCACTGCTCGCGAACGGCCAGGAGCCGCCCGAAGCGGTTCGCGAAGCGCAGGAATAC
CTGTACCAGGCCGTGCGTGATGCATTCCGGCCCGGCATGGGGGCGTACCTGCCCGACCGGTTCTTCTGGGCGCGCAGCAA
CGAAGACTCGGATACGCCGCCGGCCGTGAAGGCCGACTCGGTGCCGAGGACGTCGCACCGGCATTGA

Upstream 100 bases:

>100_bases
AAAGTGCGGCCTGCCGGGCAACACAGGGCCGAAAACGCCCACTTCGCCTCGCCGTCCGCATGTCCGTCGCTTGTCCGTTT
TTCTCTTGCCCCATTTTTAC

Downstream 100 bases:

>100_bases
GGTGCCGGGACCACGCGGGCGTTTGAACGGTCAAACGCCCGCCGCGCCCTCTCCCCCTCAACTGCAAGCATCCGCCAATC
GCACGTGAATTCGGTATCGG

Product: hydroxymethylpyrimidine/phosphomethylpyrimidine kinase-like

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSSNAPPIVLTFGLSDPTGGSGIQADLLTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFK
IGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADYATLIALAQPDGDAEAPN
LDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
LYQAVRDAFRPGMGAYLPDRFFWARSNEDSDTPPAVKADSVPRTSHRH

Sequences:

>Translated_288_residues
MSSNAPPIVLTFGLSDPTGGSGIQADLLTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFK
IGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADYATLIALAQPDGDAEAPN
LDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
LYQAVRDAFRPGMGAYLPDRFFWARSNEDSDTPPAVKADSVPRTSHRH
>Mature_287_residues
SSNAPPIVLTFGLSDPTGGSGIQADLLTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFKI
GAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADYATLIALAQPDGDAEAPNL
DAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYL
YQAVRDAFRPGMGAYLPDRFFWARSNEDSDTPPAVKADSVPRTSHRH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=244, Percent_Identity=29.5081967213115, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30573; Mature: 30442

Theoretical pI: Translated: 4.07; Mature: 4.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNAPPIVLTFGLSDPTGGSGIQADLLTLASMGCHGVSVLTGYTVRDSAACDEVTGLDP
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCEECCCCCHHHHCCCCH
DVVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHHECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADYATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSE
HHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
CCCHHHHHHHHCCCCCHHHHHHCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAVRDAFRPGMGAYLPDRFFWARSNEDSDTPPAVKADSVPRTSHRH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSNAPPIVLTFGLSDPTGGSGIQADLLTLASMGCHGVSVLTGYTVRDSAACDEVTGLDP
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCEECCCCCHHHHCCCCH
DVVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHHECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADYATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSE
HHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
CCCHHHHHHHHCCCCCHHHHHHCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAVRDAFRPGMGAYLPDRFFWARSNEDSDTPPAVKADSVPRTSHRH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]