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The map label for this gene is gyaR [H]

Identifier: 78065203

GI number: 78065203

Start: 616968

End: 617921

Strand: Direct

Name: gyaR [H]

Synonym: Bcep18194_A3727

Alternate gene names: 78065203

Gene position: 616968-617921 (Clockwise)

Preceding gene: 78065202

Following gene: 78065204

Centisome position: 16.7

GC content: 70.23

Gene sequence:

>954_bases
ATGGCGCACGAATCGACCCAGCGGCCCGACCTGCTGATGACGGGCCCTTACCAGCCGTGGGACGACGCATGGCTGGCCGG
CTATAACGTTCACCGGCTGTGGGAAGCCACCGACCGCGCGGCGTTCCTCGCCGAACACGGCGCCGGCGTGCGCGCGATCG
CGACGCGCGGCGATCTCGGCGCGAATGCCGAGCTGATCGCCGCGCTGCCGAAGCTCGAGATCATCTCCTGCTACGGCGTC
GGTACCGATGCGATCGATCTCGCCGCCGCACGTGAACGCGGCATCCGCGTGACGAACACGCCCGACGTGCTGACCGGTGA
CGTGGCCGACCTCGGCGTCGGGCTCGCACTCGCGATGATGCGCCACATCGGTGCCGGCGACGCGTACGTGCGTTCCGGCG
CATGGTCCGACGGCGACATGCCGCTCGTCACACGGCTTTACGGCAAGCGCGTCGGCGTGGTCGGCTTCGGCCGGATCGGC
ACGACGATTGCGCGTCGGCTGTCGGGTTTCGACGTCGAGCTCGGCTACTTCGACGTCGCACCGCGCACGGACAGCCCGCA
CCGTTTCTTCGGCGACCTCGCCGAGCTGGCCAGCTGGTGCGACCTGCTGATCGTCACGCTCGCGGGCGGGCCGACGACGC
GCCACCTCGTCGACGCCGCCGTGCTCGACGCGCTCGGGCCGCAAGGCTATCTGGTGAACGTGTCGCGCGGCACGACCGTC
GACGAACCGGCTTTGCTCGACGCGCTCGAGCGCAACGCGATCGCCGGCGCGGCGCTCGACGTGTTCTGGAACGAGCCGCG
CATCGACCCGCGTTTCCTCGCGTTGCAGAACGTGCTGCTGCAGCCGCACCATGCGAGCGGTACGATCGAGACGCGCCAGG
CGATGGGCTGGCTCGTGCGCGACAACCTTGCCGCGCACTTCGCCGGTGCGCCGCTGGTCACGCCGGTCGTCTGA

Upstream 100 bases:

>100_bases
GGACGCCGATGCGATCGCGCGGCACGCATGAACGGGCCGGGCGGCTGACGCGGCCCGGCACGCTTTCGCATTCAACTTAT
CTCGACAGGAGCAAGCGCAG

Downstream 100 bases:

>100_bases
GGAGGCTGTCATGCGTATGCGTTGCATGTGTGTCGTGATCCACGGGCCGAACGACCTGCGGGTGGAAGAGCAGGACGCGG
GCGAGATCGGCCCGGGCCAG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MAHESTQRPDLLMTGPYQPWDDAWLAGYNVHRLWEATDRAAFLAEHGAGVRAIATRGDLGANAELIAALPKLEIISCYGV
GTDAIDLAAARERGIRVTNTPDVLTGDVADLGVGLALAMMRHIGAGDAYVRSGAWSDGDMPLVTRLYGKRVGVVGFGRIG
TTIARRLSGFDVELGYFDVAPRTDSPHRFFGDLAELASWCDLLIVTLAGGPTTRHLVDAAVLDALGPQGYLVNVSRGTTV
DEPALLDALERNAIAGAALDVFWNEPRIDPRFLALQNVLLQPHHASGTIETRQAMGWLVRDNLAAHFAGAPLVTPVV

Sequences:

>Translated_317_residues
MAHESTQRPDLLMTGPYQPWDDAWLAGYNVHRLWEATDRAAFLAEHGAGVRAIATRGDLGANAELIAALPKLEIISCYGV
GTDAIDLAAARERGIRVTNTPDVLTGDVADLGVGLALAMMRHIGAGDAYVRSGAWSDGDMPLVTRLYGKRVGVVGFGRIG
TTIARRLSGFDVELGYFDVAPRTDSPHRFFGDLAELASWCDLLIVTLAGGPTTRHLVDAAVLDALGPQGYLVNVSRGTTV
DEPALLDALERNAIAGAALDVFWNEPRIDPRFLALQNVLLQPHHASGTIETRQAMGWLVRDNLAAHFAGAPLVTPVV
>Mature_316_residues
AHESTQRPDLLMTGPYQPWDDAWLAGYNVHRLWEATDRAAFLAEHGAGVRAIATRGDLGANAELIAALPKLEIISCYGVG
TDAIDLAAARERGIRVTNTPDVLTGDVADLGVGLALAMMRHIGAGDAYVRSGAWSDGDMPLVTRLYGKRVGVVGFGRIGT
TIARRLSGFDVELGYFDVAPRTDSPHRFFGDLAELASWCDLLIVTLAGGPTTRHLVDAAVLDALGPQGYLVNVSRGTTVD
EPALLDALERNAIAGAALDVFWNEPRIDPRFLALQNVLLQPHHASGTIETRQAMGWLVRDNLAAHFAGAPLVTPVV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=36.328125, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=31.8181818181818, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=27.7992277992278, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=27.7992277992278, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI145580575, Length=251, Percent_Identity=28.2868525896414, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082289, Length=287, Percent_Identity=33.4494773519164, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789279, Length=308, Percent_Identity=30.5194805194805, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=28.1853281853282, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=268, Percent_Identity=29.4776119402985, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=234, Percent_Identity=27.3504273504274, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324055, Length=319, Percent_Identity=30.4075235109718, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=298, Percent_Identity=27.1812080536913, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=282, Percent_Identity=27.6595744680851, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325144, Length=291, Percent_Identity=25.085910652921, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=223, Percent_Identity=26.9058295964126, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=37.4517374517375, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=33.8403041825095, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=31.2302839116719, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=31.2302839116719, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=31.2302839116719, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=31.2302839116719, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=31.2302839116719, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585516, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI19921140, Length=268, Percent_Identity=29.8507462686567, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646446, Length=215, Percent_Identity=32.093023255814, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646448, Length=215, Percent_Identity=32.093023255814, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646452, Length=215, Percent_Identity=32.093023255814, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646450, Length=215, Percent_Identity=32.093023255814, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI62472511, Length=214, Percent_Identity=31.7757009345794, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33919; Mature: 33788

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHESTQRPDLLMTGPYQPWDDAWLAGYNVHRLWEATDRAAFLAEHGAGVRAIATRGDLG
CCCCCCCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
ANAELIAALPKLEIISCYGVGTDAIDLAAARERGIRVTNTPDVLTGDVADLGVGLALAMM
CCCHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCEEECCCCCCEECCHHHHHHHHHHHHH
RHIGAGDAYVRSGAWSDGDMPLVTRLYGKRVGVVGFGRIGTTIARRLSGFDVELGYFDVA
HHCCCCCHHHCCCCCCCCCCHHHHHHHCCCCCEEEECHHHHHHHHHHCCCEEEECEEECC
PRTDSPHRFFGDLAELASWCDLLIVTLAGGPTTRHLVDAAVLDALGPQGYLVNVSRGTTV
CCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
DEPALLDALERNAIAGAALDVFWNEPRIDPRFLALQNVLLQPHHASGTIETRQAMGWLVR
CCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DNLAAHFAGAPLVTPVV
HCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AHESTQRPDLLMTGPYQPWDDAWLAGYNVHRLWEATDRAAFLAEHGAGVRAIATRGDLG
CCCCCCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
ANAELIAALPKLEIISCYGVGTDAIDLAAARERGIRVTNTPDVLTGDVADLGVGLALAMM
CCCHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCEEECCCCCCEECCHHHHHHHHHHHHH
RHIGAGDAYVRSGAWSDGDMPLVTRLYGKRVGVVGFGRIGTTIARRLSGFDVELGYFDVA
HHCCCCCHHHCCCCCCCCCCHHHHHHHCCCCCEEEECHHHHHHHHHHCCCEEEECEEECC
PRTDSPHRFFGDLAELASWCDLLIVTLAGGPTTRHLVDAAVLDALGPQGYLVNVSRGTTV
CCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
DEPALLDALERNAIAGAALDVFWNEPRIDPRFLALQNVLLQPHHASGTIETRQAMGWLVR
CCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DNLAAHFAGAPLVTPVV
HCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA