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The map label for this gene is glnA2 [H]

Identifier: 78048212

GI number: 78048212

Start: 2993534

End: 2994919

Strand: Reverse

Name: glnA2 [H]

Synonym: XCV2656

Alternate gene names: 78048212

Gene position: 2994919-2993534 (Counterclockwise)

Preceding gene: 78048213

Following gene: 78048211

Centisome position: 57.83

GC content: 63.35

Gene sequence:

>1386_bases
ATGTCCATCCGCACGCGTTCGCGCAAGACCCCGTCCAAGCAGCCGGAGAGCGCGCTGCGCCGCTGGCTGAAGGAGCGCAG
CATCACCGAGGTGGAATGCCTGGTGCCGGACATTACCGGCAACGCGCGCGGCAAGATCATTCCCGCCGACAAGTTCTCGC
ATGACTACGGGACGCGCCTGCCGGAAGGCATCTTCGCCACCACCGTGACCGGCGATTTCCCCGACGATTATTACGCGCTC
ACCTCACCGTCGGATTCGGACATGCATCTGCGCCCGGATGCCAGCACCGTGCGCATGGTGCCGTGGGCGGCCGACCCCAC
CGCGCAGGTCATCCACGACTGCTATACCAAGGATGGCCAGCCGCACGAACTTGCCCCGCGCAACGTGCTGCGCCGCGTGC
TGGACGCCTATGCCCAGGCCAAGCTGCAACCGGTGGTGGCACCGGAACTGGAGTTCTTCCTGGTGCAGAAAAATACCGAC
CCCGACTTCCCGTTGTTGCCGCCGGCAGGGCGCTCCGGGCGGCCGGAAACGGCGCGGCAGTCGTACTCGATCGACGCGGT
CAACGAGTTCGACCCCATCCTGGACCTGATGTACGACTACTGCGATGCGATGGAGCTGGACGTGGACACGCTGATCCACG
AATCCGGCGCCGCGCAGTTGGAAGTCAACTTCACCCATGCCGACCCGATGTCGCGCGCGGACCAGGTGTTCCTGTTCAAG
CGCACCATGCGCGAAGCCGCGCTGCGGCACGGTGTGTATGCCACGTTCCTGGCCAAACCAATGGAAACCGAGCCAGGCAG
TGCGATGCATATCCACCAGAGCCTGTTGCATGCCGGCACCGGCAAGAACGTGTTCAGCGGCAAGCGCGAGGGCGGTTTCA
GCGATACCTTCGCGCATTATCTGGGCGGCTTGCAGAAATACATTCCGATGGCGATGGGCCTGCTGGCGCCCAACGTCAAT
TCATACCGGCGGTTGATGTTCGGCGAGGTGTCGCCGAGCAATGTGCTGTGGGGCTTCGACAACCGCACCTGCGGGCTGCG
CGTGCCCATCGATGCGCCGCAGAACATGCGGGTGGAAAGCCGCTTTGCCGGCTCCGACGCCAACCCGTATCTGGCCATGG
CAGCGACCTTGGCCTGCGGGTTATTGGGGATCGGCGAAAAGCTCGAACCGACCGCGCCGATCAGCAGCAATGGCAAGGAG
CAGGGCTACGATTTGCCGCGCTCGCTGGGCGAAGCGCTGGATGAACTGGAAGGCTGCGAGGCGTTGCAGGAGATGTTGGG
GCGGCGGTTCGTGCGCGCATACATCTCGGTGAAGCGAAAAGAGTACGAGACGTTTTTCCGGGTCATCAGTTCGTGGGAAC
GGGAGTTCTTGTTGTTGAATGTGTGA

Upstream 100 bases:

>100_bases
GGAATGGCGTGTCACACAGCATCCGTTCTACCGTGCCATCTTTCAGGCCTTCGGCGAGGCCTGTCGCCAATACGCCGCGC
GACGCGGCAAGTGAGGTTGC

Downstream 100 bases:

>100_bases
GGCGTTCTTGCATCTCACGCGCGTGCTGTGTTCCTTCTCCTCCCGGGAAAACTGCCCGAAGGATGGATGAGGGCAACCTC
GGCGGCAACGGAAGTTCTCG

Product: putative glutamine synthetase

Products: NA

Alternate protein names: Gamma-Glu-Put synthetase; Glutamate--putrescine ligase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSIRTRSRKTPSKQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRLPEGIFATTVTGDFPDDYYAL
TSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQPHELAPRNVLRRVLDAYAQAKLQPVVAPELEFFLVQKNTD
PDFPLLPPAGRSGRPETARQSYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHYLGGLQKYIPMAMGLLAPNVN
SYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDAPQNMRVESRFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKE
QGYDLPRSLGEALDELEGCEALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV

Sequences:

>Translated_461_residues
MSIRTRSRKTPSKQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRLPEGIFATTVTGDFPDDYYAL
TSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQPHELAPRNVLRRVLDAYAQAKLQPVVAPELEFFLVQKNTD
PDFPLLPPAGRSGRPETARQSYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHYLGGLQKYIPMAMGLLAPNVN
SYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDAPQNMRVESRFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKE
QGYDLPRSLGEALDELEGCEALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV
>Mature_460_residues
SIRTRSRKTPSKQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRLPEGIFATTVTGDFPDDYYALT
SPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQPHELAPRNVLRRVLDAYAQAKLQPVVAPELEFFLVQKNTDP
DFPLLPPAGRSGRPETARQSYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFKR
TMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHYLGGLQKYIPMAMGLLAPNVNS
YRRLMFGEVSPSNVLWGFDNRTCGLRVPIDAPQNMRVESRFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKEQ
GYDLPRSLGEALDELEGCEALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV

Specific function: Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine [H]

COG id: COG0174

COG function: function code E; Glutamine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamine synthetase family [H]

Homologues:

Organism=Homo sapiens, GI221307485, Length=443, Percent_Identity=26.1851015801354, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI87081870, Length=450, Percent_Identity=36.2222222222222, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1790301, Length=461, Percent_Identity=29.0672451193059, Blast_Score=148, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008147
- InterPro:   IPR014746
- InterPro:   IPR008146 [H]

Pfam domain/function: PF00120 Gln-synt_C [H]

EC number: =6.3.1.11 [H]

Molecular weight: Translated: 51491; Mature: 51360

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00181 GLNA_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRTRSRKTPSKQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCCCCCHHCCCC
PEGIFATTVTGDFPDDYYALTSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQ
CCCEEEEEEECCCCCCCEEECCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHCCCCC
PHELAPRNVLRRVLDAYAQAKLQPVVAPELEFFLVQKNTDPDFPLLPPAGRSGRPETARQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
SYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHY
HHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LGGLQKYIPMAMGLLAPNVNSYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDAPQNMRVES
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECCCCCCCCEEECCCCCCCCEEHH
RFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKEQGYDLPRSLGEALDELEGCE
HCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
SIRTRSRKTPSKQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCCCCCHHCCCC
PEGIFATTVTGDFPDDYYALTSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQ
CCCEEEEEEECCCCCCCEEECCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHCCCCC
PHELAPRNVLRRVLDAYAQAKLQPVVAPELEFFLVQKNTDPDFPLLPPAGRSGRPETARQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
SYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHY
HHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LGGLQKYIPMAMGLLAPNVNSYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDAPQNMRVES
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECCCCCCCCEEECCCCCCCCEEHH
RFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKEQGYDLPRSLGEALDELEGCE
HCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]