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The map label for this gene is hisC [H]

Identifier: 78047223

GI number: 78047223

Start: 1875855

End: 1876979

Strand: Reverse

Name: hisC [H]

Synonym: XCV1667

Alternate gene names: 78047223

Gene position: 1876979-1875855 (Counterclockwise)

Preceding gene: 78047231

Following gene: 78047215

Centisome position: 36.25

GC content: 69.42

Gene sequence:

>1125_bases
GTGTCGTTGCCCGTCTCGCGCCGTTCGTTTCTCAGCCTCGCTACCACCGGCGTGGCGGTTTCCGCACTGGGGCTGGCACC
CGCAGCCGAAGCGGCCCGCAAGCGCGCCGCGGCGGCGGCAACGCCGGGCGTGGCCGCGGCGGCCGGCACGGTCTACCTCA
ACCTCAACGAGCATCCGCTCGGGCCTGCCCCGGCCGCCTTGGACGCTGCCACCCGTTCGCTGGCACGCTCGGGCCGCTAC
CTGCTCGAGATGGAGCAGGATCTGCGTAACCTGATGACCGGCGAGCTGCAGCTGCCCAACGATCATCTGTCGTTATTCCC
CGGGTCGCGGGACGCGCTGAACCGTGCCGGCAGCCTGTTCACGTCCGCGCGTGCAGGGCTGGTGGTGGCCGACCCGAGCT
TCGACCCGTTGATCGAAAGCGCCACCGCCCGCGGCGTGGCCGTACGCAAGGTGCCGCTGCGTGCCGATGGCGCGCATGAC
GTCAAGGCGATGGCCAAGGCCGACCCGACTGCCGGCATGCTGTATCTGTGCAACCCCGGCAACGCCACCGGCGCCATCAC
CCCGCGCGCCGACATCGAATGGTTGCTGGCCAACAAACCGGCCAGCGCCGTGCTGGTGGTCGACGAGGCGTACATCCACT
ACAGCAACGAGCCCTCGGTGGCCGATCTGGTGCGTCAGCGCCAGGATCTGATCGTGCTGCGCAGCTTCTCCAAGCTCTAC
GGCATGGCCGGCCTGCGCCTGGGCGCCGCCCTGGCCCCGCCCGGCCTGCAGACCAAACTTGCCGCTTTCGGCAGCAACCC
GGTGTCGGTTCCGGCAATGGCCGCCGGTATCGCCAGCCTGCGCGACCCGCTGCTGGTGCAGACCCGCCGCGCCGAGAACG
CCCGGGTGCGCGAGGAGACCATCGCCTGGCTCAAGGGCAAGGGCTACACCTGCCTGCCCTCGCAAGCCAACTGCTTCCTG
CTGGACGTCAAGCGCGATGCGAGCGTGTTCGCCGATTCGATGCAAAAGCAGGGCGTCATCGTCGGCCGCAGCTGGCCGAT
CTGGCCCAAGCGCGTGCGCGTCAGCGTGGGGACCGAAGCGGAAATGCTGCGCTTCCGCGAGGCATTCGGGAAAGCCAAGC
GTTGA

Upstream 100 bases:

>100_bases
AAGCATGCGTCGAACAGTTTTATGGCAATTCCCCGATAGGCAGATAGACACAAACCCGCTAGCGTGGCGCCCTCTTTGCC
CGCCGCCTATGGAGTTCGCC

Downstream 100 bases:

>100_bases
GCACTCAGTACTGAATGGTAGATCCTTCTCCACTCGGGACATTGTCCTCCTTCATGGGGGAGAAGGTGCCCCGAAGGGGT
GGATGAGGGTGCGAGCGACG

Product: putative aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSLPVSRRSFLSLATTGVAVSALGLAPAAEAARKRAAAAATPGVAAAAGTVYLNLNEHPLGPAPAALDAATRSLARSGRY
LLEMEQDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLFTSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHD
VKAMAKADPTAGMLYLCNPGNATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
GMAGLRLGAALAPPGLQTKLAAFGSNPVSVPAMAAGIASLRDPLLVQTRRAENARVREETIAWLKGKGYTCLPSQANCFL
LDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEAEMLRFREAFGKAKR

Sequences:

>Translated_374_residues
MSLPVSRRSFLSLATTGVAVSALGLAPAAEAARKRAAAAATPGVAAAAGTVYLNLNEHPLGPAPAALDAATRSLARSGRY
LLEMEQDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLFTSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHD
VKAMAKADPTAGMLYLCNPGNATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
GMAGLRLGAALAPPGLQTKLAAFGSNPVSVPAMAAGIASLRDPLLVQTRRAENARVREETIAWLKGKGYTCLPSQANCFL
LDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEAEMLRFREAFGKAKR
>Mature_373_residues
SLPVSRRSFLSLATTGVAVSALGLAPAAEAARKRAAAAATPGVAAAAGTVYLNLNEHPLGPAPAALDAATRSLARSGRYL
LEMEQDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLFTSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHDV
KAMAKADPTAGMLYLCNPGNATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLYG
MAGLRLGAALAPPGLQTKLAAFGSNPVSVPAMAAGIASLRDPLLVQTRRAENARVREETIAWLKGKGYTCLPSQANCFLL
DVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEAEMLRFREAFGKAKR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=253, Percent_Identity=28.0632411067194, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=279, Percent_Identity=27.9569892473118, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39656; Mature: 39525

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPVSRRSFLSLATTGVAVSALGLAPAAEAARKRAAAAATPGVAAAAGTVYLNLNEHPL
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCEEEEEECCCCC
GPAPAALDAATRSLARSGRYLLEMEQDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLF
CCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCEECCCCCEEECCCCHHHHHHHHHHH
TSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHDVKAMAKADPTAGMLYLCNPG
HHCCCCEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCC
NATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
CCCCEECCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GMAGLRLGAALAPPGLQTKLAAFGSNPVSVPAMAAGIASLRDPLLVQTRRAENARVREET
HHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
IAWLKGKGYTCLPSQANCFLLDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEA
HHHCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCEEEEEECCHH
EMLRFREAFGKAKR
HHHHHHHHHCCCCC
>Mature Secondary Structure 
SLPVSRRSFLSLATTGVAVSALGLAPAAEAARKRAAAAATPGVAAAAGTVYLNLNEHPL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCEEEEEECCCCC
GPAPAALDAATRSLARSGRYLLEMEQDLRNLMTGELQLPNDHLSLFPGSRDALNRAGSLF
CCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCEECCCCCEEECCCCHHHHHHHHHHH
TSARAGLVVADPSFDPLIESATARGVAVRKVPLRADGAHDVKAMAKADPTAGMLYLCNPG
HHCCCCEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCC
NATGAITPRADIEWLLANKPASAVLVVDEAYIHYSNEPSVADLVRQRQDLIVLRSFSKLY
CCCCEECCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GMAGLRLGAALAPPGLQTKLAAFGSNPVSVPAMAAGIASLRDPLLVQTRRAENARVREET
HHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
IAWLKGKGYTCLPSQANCFLLDVKRDASVFADSMQKQGVIVGRSWPIWPKRVRVSVGTEA
HHHCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCEEEEEECCHH
EMLRFREAFGKAKR
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]