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The map label for this gene is pyrH [H]

Identifier: 78047032

GI number: 78047032

Start: 1658478

End: 1659200

Strand: Reverse

Name: pyrH [H]

Synonym: XCV1476

Alternate gene names: 78047032

Gene position: 1659200-1658478 (Counterclockwise)

Preceding gene: 78047033

Following gene: 78047031

Centisome position: 32.04

GC content: 65.28

Gene sequence:

>723_bases
ATGTCCGAACTTTCCTATCGCCGCATTCTTCTCAAACTTTCCGGGGAGGCGCTGATGGGGGACGGGGATTACGGCATCGA
CCCCAAGGTCATCAATCGCCTGGCGCATGAAGTGATCGAAGCCCAGCAGGCCGGCGCGCAGGTGGCGCTGGTGATCGGCG
GTGGCAACATCTTCCGCGGCGCCGGCCTGGCTGCCAGCGGCATGGACCGCGTCACCGGCGACCACATGGGCATGCTGGCC
ACGGTGATCAACGCGCTGGCGATGCAGGATGCGCTGGAAAAGCTCGGCGCCAAGGTGCGCGTGATGAGCGCCATCAAGAT
CAACGATGTCTGCGAAGACTTCATCCGTCGCCGTGCGATCCGTCACCTGGAGAAGGGCCGCATCGCGATCTTCGCCGCCG
GCACCGGCAACCCGTTCTTCACCACCGACTCGGGCGCAGCGCTGCGCGCGATCGAGATCGGTGCCGACCTGCTGCTCAAG
GCAACCAAGGTCGACGGCGTGTACGACAAGGACCCGAAGAAGCACACCGATGCGGTGCGCTACGACAGCCTGACCTACGA
CCAGGTGATCCTGCAGGGCCTGGAAGTGATGGATACCGCCGCCTTCGCACTGGCGCGCGACAGCGACCTGCCGCTGCGCA
TCTTCGGCATGAGCGAACCGGGCGTGCTGCTGCGCATCCTGCACGGCGAGCAGATCGGCACGTTGGTGCAGGGCCGCAGC
TGA

Upstream 100 bases:

>100_bases
GGTCACGCCACTGCCAACAAAGGAATTTTTACCACGCCAGGTGACAGGCTTCCGCTAGAATTGCCGGCGTTTGCCGATCC
CCCACCCCCGAGGTTTCCCC

Downstream 100 bases:

>100_bases
GGTCGGGAATCGGGATTGGGGAATCGCAAGAGCGCACGGCCGCAGGCTGCACAGCGATCTCCAACCCGGCGCCCGGCGTG
AAAAGGGGCGCCAAGTGAAC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLA
TVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLK
ATKVDGVYDKDPKKHTDAVRYDSLTYDQVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS

Sequences:

>Translated_240_residues
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLA
TVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLK
ATKVDGVYDKDPKKHTDAVRYDSLTYDQVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS
>Mature_239_residues
SELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLAT
VINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKA
TKVDGVYDKDPKKHTDAVRYDSLTYDQVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=57.5757575757576, Blast_Score=273, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25805; Mature: 25674

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRG
CCCCHHHHEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
AGLAASGMDRVTGDHMGMLATVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHH
RHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGVYDKDPKKHTDAVR
HHHCCCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHEEECCCCCCCCCCCCHHCCHHH
YDSLTYDQVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHCCCC
>Mature Secondary Structure 
SELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRG
CCCHHHHEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
AGLAASGMDRVTGDHMGMLATVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHH
RHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGVYDKDPKKHTDAVR
HHHCCCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHEEECCCCCCCCCCCCHHCCHHH
YDSLTYDQVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]