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The map label for this gene is guaA

Identifier: 78044956

GI number: 78044956

Start: 944102

End: 945631

Strand: Direct

Name: guaA

Synonym: CHY_1068

Alternate gene names: 78044956

Gene position: 944102-945631 (Clockwise)

Preceding gene: 78042635

Following gene: 78043950

Centisome position: 39.31

GC content: 49.15

Gene sequence:

>1530_bases
ATGGCGTCAAAGGTAATTGTTTTGGATTTTGGAGGACAGTACAGTCAGTTAATTGCCCGGCGCATCCGGGAGTTAAAAGT
ATACTGTGAAATGTTACCGTATAATACCCCCCTGGAAAAAATCGTCCAAGAAAACCCAGGGGGGATTGTGTTTTCTGGAG
GGCCTTCGTCGGTTTACGGAGAAGGGGCACCGACGGTAGATCCGGAAATATACCGTTTGAATATTCCCATCCTGGGTATC
TGTTACGGAATGCAGCTGATGGCCCACCAGCTCGGGGGCATTGTGCGGCCTGCTGAAGGCAGGGAATACGGCAAAACGCC
CCTTTTTATCTTAAATCGGGACAGGCTTTTTGCCGGACTTAATGAGACCGAAATTTGCTGGATGAGCCACGGGGATTTTG
TGGCAAAAGCCCCCGAGGGATTTTTGGTTACGGCTAAAACCGAGTATACGCCTATTGCCGCTATGGAAAACCGGGAAAGA
AATCTTTATGCGGTGCAGTTTCATCCGGAAGTGGTTCATACCCCTAAAGGAAAGGAAATTCTTAAAAATTTCCTCTACGA
AATTTGCGGCTTAACACCCGACTGGACGATGGAATCTTTTGCCCAGAAGGCCATTCGGGAAATCAAGGAACAGGTGGGTG
AGGAGAAGGTCGTCTGTGCCCTTTCCGGCGGGGTTGACAGCTCCGTGGCAGCGGTTTTGGTGCATAAAGCCATCGGTGAT
AATTTAACCTGCATTTTTGTGGACCACGGGTTACTGCGCAAAGGGGAGGCGGAAGAAGTTGTCCGCACCTTTAAAGAACA
GTTTCAAATGAACTTAGTTTTTGTGGATGCCAAGGAGCAGTTTTTGGCTAAATTAAAAGGTGTTCGTGACCCCGAACAGA
AAAGAAAAATCATCGGCCATGAATTTATCCGGGTTTTTGAAGAAGAAGCGGCCAAACTTGGAGATATCCGTTTTCTCGTC
CAGGGGACTTTATATCCGGATGTGGTGGAAAGCGGTACCGCCACCGCTGCTACCATTAAATCCCACCACAATGTGGGTGG
TTTACCGGAAGATATGAAGTTTCAGCTTATCGAGCCTTTAAAGTGGCTGTTTAAAGATGAAGTCCGGGAATTAGGCCTTG
AGCTGGGGCTTCCGGAAAGTATAGTCTGGCGCCATCCTTTCCCGGGACCGGGACTTGCGGTCCGGGTGTTAGGGGAGATA
ACCGAAGAGAAACTTGCCATACTAAGGGAGGCAGATTACATTTTTATAGATGAATTAAAGAAATCCGGCTGGTACCGGAA
AACCTGGCAGGCCTTTGCGGTGCTGCCGAATCTCCAGTCCGTGGGGGTTATGGGGGACGAAAGGACCTATGCCTATACCA
TAGCGTTGCGAGCGGTGACCAGCGAAGATGGCATGACTGCCGACTGGGTCCGGTTGCCTTATGAGTTGCTGGAAAAAATC
TCTGCCCGCATCGTAGGTGAAGTTAAAGGAGTAAACCGGGTAGTGTATGATATCACCAGCAAACCCCCTGCTACTATTGA
ATGGGAGTAG

Upstream 100 bases:

>100_bases
TCCCTACATCGGCGTCTTAAAACCGGAGATTTACCGGGAATAATTTTAATTACACCTACAACCCACCACATACCACTTAC
CACTTTTAAAGGAGGTTTTT

Downstream 100 bases:

>100_bases
TAGGGGTTTACTTTTTCATAATTTTATAGGAGGTGTTTACAATGCACAAAGTTGCGGTGGTTATGGGAAGCGACTCCGAC
TGGGAGATTGTAAAAAAGGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MASKVIVLDFGGQYSQLIARRIRELKVYCEMLPYNTPLEKIVQENPGGIVFSGGPSSVYGEGAPTVDPEIYRLNIPILGI
CYGMQLMAHQLGGIVRPAEGREYGKTPLFILNRDRLFAGLNETEICWMSHGDFVAKAPEGFLVTAKTEYTPIAAMENRER
NLYAVQFHPEVVHTPKGKEILKNFLYEICGLTPDWTMESFAQKAIREIKEQVGEEKVVCALSGGVDSSVAAVLVHKAIGD
NLTCIFVDHGLLRKGEAEEVVRTFKEQFQMNLVFVDAKEQFLAKLKGVRDPEQKRKIIGHEFIRVFEEEAAKLGDIRFLV
QGTLYPDVVESGTATAATIKSHHNVGGLPEDMKFQLIEPLKWLFKDEVRELGLELGLPESIVWRHPFPGPGLAVRVLGEI
TEEKLAILREADYIFIDELKKSGWYRKTWQAFAVLPNLQSVGVMGDERTYAYTIALRAVTSEDGMTADWVRLPYELLEKI
SARIVGEVKGVNRVVYDITSKPPATIEWE

Sequences:

>Translated_509_residues
MASKVIVLDFGGQYSQLIARRIRELKVYCEMLPYNTPLEKIVQENPGGIVFSGGPSSVYGEGAPTVDPEIYRLNIPILGI
CYGMQLMAHQLGGIVRPAEGREYGKTPLFILNRDRLFAGLNETEICWMSHGDFVAKAPEGFLVTAKTEYTPIAAMENRER
NLYAVQFHPEVVHTPKGKEILKNFLYEICGLTPDWTMESFAQKAIREIKEQVGEEKVVCALSGGVDSSVAAVLVHKAIGD
NLTCIFVDHGLLRKGEAEEVVRTFKEQFQMNLVFVDAKEQFLAKLKGVRDPEQKRKIIGHEFIRVFEEEAAKLGDIRFLV
QGTLYPDVVESGTATAATIKSHHNVGGLPEDMKFQLIEPLKWLFKDEVRELGLELGLPESIVWRHPFPGPGLAVRVLGEI
TEEKLAILREADYIFIDELKKSGWYRKTWQAFAVLPNLQSVGVMGDERTYAYTIALRAVTSEDGMTADWVRLPYELLEKI
SARIVGEVKGVNRVVYDITSKPPATIEWE
>Mature_508_residues
ASKVIVLDFGGQYSQLIARRIRELKVYCEMLPYNTPLEKIVQENPGGIVFSGGPSSVYGEGAPTVDPEIYRLNIPILGIC
YGMQLMAHQLGGIVRPAEGREYGKTPLFILNRDRLFAGLNETEICWMSHGDFVAKAPEGFLVTAKTEYTPIAAMENRERN
LYAVQFHPEVVHTPKGKEILKNFLYEICGLTPDWTMESFAQKAIREIKEQVGEEKVVCALSGGVDSSVAAVLVHKAIGDN
LTCIFVDHGLLRKGEAEEVVRTFKEQFQMNLVFVDAKEQFLAKLKGVRDPEQKRKIIGHEFIRVFEEEAAKLGDIRFLVQ
GTLYPDVVESGTATAATIKSHHNVGGLPEDMKFQLIEPLKWLFKDEVRELGLELGLPESIVWRHPFPGPGLAVRVLGEIT
EEKLAILREADYIFIDELKKSGWYRKTWQAFAVLPNLQSVGVMGDERTYAYTIALRAVTSEDGMTADWVRLPYELLEKIS
ARIVGEVKGVNRVVYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=37.4545454545455, Blast_Score=312, Evalue=5e-85,
Organism=Escherichia coli, GI1788854, Length=517, Percent_Identity=52.0309477756286, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1789760, Length=151, Percent_Identity=34.4370860927152, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=37.6325088339223, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=37.6325088339223, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=37.6325088339223, Blast_Score=333, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=52.3166023166023, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI281365319, Length=546, Percent_Identity=37.9120879120879, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CARHZ (Q3AD70)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359914.1
- ProteinModelPortal:   Q3AD70
- SMR:   Q3AD70
- STRING:   Q3AD70
- GeneID:   3728081
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1068
- NMPDR:   fig|246194.3.peg.868
- TIGR:   CHY_1068
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   PSTIEPC
- ProtClustDB:   PRK00074
- BioCyc:   CHYD246194:CHY_1068-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57148; Mature: 57017

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 81-81 ACT_SITE 168-168 ACT_SITE 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKVIVLDFGGQYSQLIARRIRELKVYCEMLPYNTPLEKIVQENPGGIVFSGGPSSVYG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCCCCCC
EGAPTVDPEIYRLNIPILGICYGMQLMAHQLGGIVRPAEGREYGKTPLFILNRDRLFAGL
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCEEECC
NETEICWMSHGDFVAKAPEGFLVTAKTEYTPIAAMENRERNLYAVQFHPEVVHTPKGKEI
CCCEEEEEECCCEEEECCCCEEEEEECCCCCCHHHCCCCCCEEEEEECCCEEECCCCHHH
LKNFLYEICGLTPDWTMESFAQKAIREIKEQVGEEKVVCALSGGVDSSVAAVLVHKAIGD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCC
NLTCIFVDHGLLRKGEAEEVVRTFKEQFQMNLVFVDAKEQFLAKLKGVRDPEQKRKIIGH
CEEEEEECCCCCCCCCHHHHHHHHHHHHEEEEEEEECHHHHHHHHCCCCCHHHHHHHHHH
EFIRVFEEEAAKLGDIRFLVQGTLYPDVVESGTATAATIKSHHNVGGLPEDMKFQLIEPL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHCCCCCEEEEHHCCCCCCCCCCCHHHHHHHHH
KWLFKDEVRELGLELGLPESIVWRHPFPGPGLAVRVLGEITEEKLAILREADYIFIDELK
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHH
KSGWYRKTWQAFAVLPNLQSVGVMGDERTYAYTIALRAVTSEDGMTADWVRLPYELLEKI
HCCCHHHHHHHHHCCCCCHHCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHCHHHHHHHH
SARIVGEVKGVNRVVYDITSKPPATIEWE
HHHHHHHHCCCCEEEEEECCCCCCEEECC
>Mature Secondary Structure 
ASKVIVLDFGGQYSQLIARRIRELKVYCEMLPYNTPLEKIVQENPGGIVFSGGPSSVYG
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCCCCCC
EGAPTVDPEIYRLNIPILGICYGMQLMAHQLGGIVRPAEGREYGKTPLFILNRDRLFAGL
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCEEECC
NETEICWMSHGDFVAKAPEGFLVTAKTEYTPIAAMENRERNLYAVQFHPEVVHTPKGKEI
CCCEEEEEECCCEEEECCCCEEEEEECCCCCCHHHCCCCCCEEEEEECCCEEECCCCHHH
LKNFLYEICGLTPDWTMESFAQKAIREIKEQVGEEKVVCALSGGVDSSVAAVLVHKAIGD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCC
NLTCIFVDHGLLRKGEAEEVVRTFKEQFQMNLVFVDAKEQFLAKLKGVRDPEQKRKIIGH
CEEEEEECCCCCCCCCHHHHHHHHHHHHEEEEEEEECHHHHHHHHCCCCCHHHHHHHHHH
EFIRVFEEEAAKLGDIRFLVQGTLYPDVVESGTATAATIKSHHNVGGLPEDMKFQLIEPL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHCCCCCEEEEHHCCCCCCCCCCCHHHHHHHHH
KWLFKDEVRELGLELGLPESIVWRHPFPGPGLAVRVLGEITEEKLAILREADYIFIDELK
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHH
KSGWYRKTWQAFAVLPNLQSVGVMGDERTYAYTIALRAVTSEDGMTADWVRLPYELLEKI
HCCCHHHHHHHHHCCCCCHHCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHCHHHHHHHH
SARIVGEVKGVNRVVYDITSKPPATIEWE
HHHHHHHHCCCCEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA