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The map label for this gene is purE [H]

Identifier: 78043950

GI number: 78043950

Start: 945673

End: 946161

Strand: Direct

Name: purE [H]

Synonym: CHY_1069

Alternate gene names: 78043950

Gene position: 945673-946161 (Clockwise)

Preceding gene: 78044956

Following gene: 78043887

Centisome position: 39.38

GC content: 48.88

Gene sequence:

>489_bases
ATGCACAAAGTTGCGGTGGTTATGGGAAGCGACTCCGACTGGGAGATTGTAAAAAAGGCGGTAGAGGTTTTAAAAGAGTT
TGGGGTGGAGTATGAAGTTAAGGTGGCATCGGCCCACCGAACTCCGGATAAAGCTTTAAATTTTGCCCGGACGGCCCGGG
AAAAAGGTTTTGGCGTTATAATTGCCGCGGCGGGGATGGCGGCCCACTTGCCGGGAGTGCTGGCAGCGGTGACCACGTTA
CCGGTGATAGGTTTACCGATTAAAGCTTCCATAGAGGGAATTGACAGCTTACTATCCATTGCCCAGATGCCACCCGGCGT
TCCGGTGGCAACGGTAGGGATAAATGCGGCTAAAAATGCCGGGCTTTTAGCGGTGCAAATTCTAAGCTTAAATGACAAAA
ACCTTGCGGGAAAACTTCAAGCTTATAAAGAAAAGCTGGCCCGGGAAGTGGAAGAAAAGGAGCAAAAACTTTTAGAAAAA
TTGTTTTAG

Upstream 100 bases:

>100_bases
TAAACCGGGTAGTGTATGATATCACCAGCAAACCCCCTGCTACTATTGAATGGGAGTAGTAGGGGTTTACTTTTTCATAA
TTTTATAGGAGGTGTTTACA

Downstream 100 bases:

>100_bases
TTCATTTTGGAGGTGTTTTTGATGATAGCCCGTTATACTTTACCGGAAATGAAAAAACTCTGGTCGGATGAAACCAAGTA
CCAAAACTGGCTAAAAGTTG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MHKVAVVMGSDSDWEIVKKAVEVLKEFGVEYEVKVASAHRTPDKALNFARTAREKGFGVIIAAAGMAAHLPGVLAAVTTL
PVIGLPIKASIEGIDSLLSIAQMPPGVPVATVGINAAKNAGLLAVQILSLNDKNLAGKLQAYKEKLAREVEEKEQKLLEK
LF

Sequences:

>Translated_162_residues
MHKVAVVMGSDSDWEIVKKAVEVLKEFGVEYEVKVASAHRTPDKALNFARTAREKGFGVIIAAAGMAAHLPGVLAAVTTL
PVIGLPIKASIEGIDSLLSIAQMPPGVPVATVGINAAKNAGLLAVQILSLNDKNLAGKLQAYKEKLAREVEEKEQKLLEK
LF
>Mature_162_residues
MHKVAVVMGSDSDWEIVKKAVEVLKEFGVEYEVKVASAHRTPDKALNFARTAREKGFGVIIAAAGMAAHLPGVLAAVTTL
PVIGLPIKASIEGIDSLLSIAQMPPGVPVATVGINAAKNAGLLAVQILSLNDKNLAGKLQAYKEKLAREVEEKEQKLLEK
LF

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=50, Blast_Score=126, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17531275, Length=110, Percent_Identity=37.2727272727273, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324702, Length=155, Percent_Identity=52.258064516129, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17206; Mature: 17206

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKVAVVMGSDSDWEIVKKAVEVLKEFGVEYEVKVASAHRTPDKALNFARTAREKGFGVI
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEE
IAAAGMAAHLPGVLAAVTTLPVIGLPIKASIEGIDSLLSIAQMPPGVPVATVGINAAKNA
EEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
GLLAVQILSLNDKNLAGKLQAYKEKLAREVEEKEQKLLEKLF
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHKVAVVMGSDSDWEIVKKAVEVLKEFGVEYEVKVASAHRTPDKALNFARTAREKGFGVI
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEE
IAAAGMAAHLPGVLAAVTTLPVIGLPIKASIEGIDSLLSIAQMPPGVPVATVGINAAKNA
EEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
GLLAVQILSLNDKNLAGKLQAYKEKLAREVEEKEQKLLEKLF
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]