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The map label for this gene is hisC1

Identifier: 78044277

GI number: 78044277

Start: 962768

End: 963817

Strand: Direct

Name: hisC1

Synonym: CHY_1086

Alternate gene names: 78044277

Gene position: 962768-963817 (Clockwise)

Preceding gene: 78044940

Following gene: 78042790

Centisome position: 40.09

GC content: 41.33

Gene sequence:

>1050_bases
ATGAATAAGCCGAGATATTTTAAAGAAGCCTTTGCCCAGCTAAAGCCCTACGAACCTCATCTGGTTTCCTATGAAATTAA
ACTTGATGCCAATGAAAACCCGTATCTTTTTCCAAAAAGTTTACTGGAAGAAATCTTCTCCAAAATTGGGACAAGGGATT
TTCCCCTTTATCCCGATCCCTTGGCTGGGAGGCTTCGTATTAGACTCTCGGAAAAGCTTGGGGTTTTGCCGGAAAATATA
GTTTTAGGAAATGGTTCCGATGAGTTGATTCTTTGCCTTTATTTAGCCTTTGGGGGATACGGGAGGATTGCCTTAAGTTT
TTCTCCTTCCTTTGTGATGTATCGACACCATGCTTTTGTAACCCAAACGGAATTTTTCGAAGTTTCGTACCGGGATGATT
TTAGCCTTGATCTGGATGAAACGAAAAAAGCCATTGAAAAGTATCAACCCCATTTAGTGTTTCTGGCCAATCCCAATAAC
CCGACGGGAACCCTGGTGGATATAGAAACGATTAAAAAGCTTTTAGCTTACGACCATTTGCTGGTAGTGGATGAGGCGTA
CGTGGAATTTTCGGGAGTTTCGGCGATAGATTTATTAAAAAAATATCAAAACCTTGTTATTTTGCGGACCTTTTCCAAAG
CCCGGGCTCTGGCCGGCTTAAGGTTGGGATATTTAGTTGCCAGCGTTGATGTGGTAAAGGAAATTATCAAGGTAAAAAAT
CCCTATAATGTAAATGTTTTTTCCCAGATTGCCGGGGAAGTGGTTTTGGCCAACGAAGAAGTTTTTCAAGGGGAAATTAA
AGAAATCGTAGCCGAAAGGGAAAGGCTTTATAACCAGTTAGCTTCTTTGGGTTTAAAGCCGGTGAAAAGCCACGCTAATT
TTATACTGGTGGAATTCGGGGAAAAGGCAAAAAAGATTCACCAGGAGTTAATTAACCACGGAATTTTAGTGCGGTACTTG
GGAGGAGCCCTTGCTAATTATTTACGGATAACCGTTGGTACACCGGAAGAAAACCGGCAACTTTTAAAGAAACTGGGGGA
AATCTTATGA

Upstream 100 bases:

>100_bases
TCCCAAGAAGGTTTTTTGGCCGATGCCAGGGATGTTATTAAACTTGCCGAAACGGAAGGGCTATTTGCCCACGCCCTTTC
GGTGAAAGTGAGGATTTCCA

Downstream 100 bases:

>100_bases
GGCGGGCCGAGGTACAACGAACAACATTAGAAACCATGATTAATGTGGAGTTTACAATGGACGGAAACGGGGAGTTTTCC
GGAACTTCAGGCCTTGGGTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNKPRYFKEAFAQLKPYEPHLVSYEIKLDANENPYLFPKSLLEEIFSKIGTRDFPLYPDPLAGRLRIRLSEKLGVLPENI
VLGNGSDELILCLYLAFGGYGRIALSFSPSFVMYRHHAFVTQTEFFEVSYRDDFSLDLDETKKAIEKYQPHLVFLANPNN
PTGTLVDIETIKKLLAYDHLLVVDEAYVEFSGVSAIDLLKKYQNLVILRTFSKARALAGLRLGYLVASVDVVKEIIKVKN
PYNVNVFSQIAGEVVLANEEVFQGEIKEIVAERERLYNQLASLGLKPVKSHANFILVEFGEKAKKIHQELINHGILVRYL
GGALANYLRITVGTPEENRQLLKKLGEIL

Sequences:

>Translated_349_residues
MNKPRYFKEAFAQLKPYEPHLVSYEIKLDANENPYLFPKSLLEEIFSKIGTRDFPLYPDPLAGRLRIRLSEKLGVLPENI
VLGNGSDELILCLYLAFGGYGRIALSFSPSFVMYRHHAFVTQTEFFEVSYRDDFSLDLDETKKAIEKYQPHLVFLANPNN
PTGTLVDIETIKKLLAYDHLLVVDEAYVEFSGVSAIDLLKKYQNLVILRTFSKARALAGLRLGYLVASVDVVKEIIKVKN
PYNVNVFSQIAGEVVLANEEVFQGEIKEIVAERERLYNQLASLGLKPVKSHANFILVEFGEKAKKIHQELINHGILVRYL
GGALANYLRITVGTPEENRQLLKKLGEIL
>Mature_349_residues
MNKPRYFKEAFAQLKPYEPHLVSYEIKLDANENPYLFPKSLLEEIFSKIGTRDFPLYPDPLAGRLRIRLSEKLGVLPENI
VLGNGSDELILCLYLAFGGYGRIALSFSPSFVMYRHHAFVTQTEFFEVSYRDDFSLDLDETKKAIEKYQPHLVFLANPNN
PTGTLVDIETIKKLLAYDHLLVVDEAYVEFSGVSAIDLLKKYQNLVILRTFSKARALAGLRLGYLVASVDVVKEIIKVKN
PYNVNVFSQIAGEVVLANEEVFQGEIKEIVAERERLYNQLASLGLKPVKSHANFILVEFGEKAKKIHQELINHGILVRYL
GGALANYLRITVGTPEENRQLLKKLGEIL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=332, Percent_Identity=31.0240963855422, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=388, Percent_Identity=31.9587628865979, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_CARHZ (Q3AD52)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359932.1
- ProteinModelPortal:   Q3AD52
- SMR:   Q3AD52
- STRING:   Q3AD52
- GeneID:   3727394
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1086
- NMPDR:   fig|246194.3.peg.1133
- TIGR:   CHY_1086
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- BioCyc:   CHYD246194:CHY_1086-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39608; Mature: 39608

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPRYFKEAFAQLKPYEPHLVSYEIKLDANENPYLFPKSLLEEIFSKIGTRDFPLYPDP
CCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEECHHHHHHHHHHHHCCCCCCCCCCC
LAGRLRIRLSEKLGVLPENIVLGNGSDELILCLYLAFGGYGRIALSFSPSFVMYRHHAFV
CCCEEEEEEHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEECCCEEEEEHHHEE
TQTEFFEVSYRDDFSLDLDETKKAIEKYQPHLVFLANPNNPTGTLVDIETIKKLLAYDHL
EEEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHE
LVVDEAYVEFSGVSAIDLLKKYQNLVILRTFSKARALAGLRLGYLVASVDVVKEIIKVKN
EEEEHHHHHCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PYNVNVFSQIAGEVVLANEEVFQGEIKEIVAERERLYNQLASLGLKPVKSHANFILVEFG
CCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECC
EKAKKIHQELINHGILVRYLGGALANYLRITVGTPEENRQLLKKLGEIL
HHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKPRYFKEAFAQLKPYEPHLVSYEIKLDANENPYLFPKSLLEEIFSKIGTRDFPLYPDP
CCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEECHHHHHHHHHHHHCCCCCCCCCCC
LAGRLRIRLSEKLGVLPENIVLGNGSDELILCLYLAFGGYGRIALSFSPSFVMYRHHAFV
CCCEEEEEEHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEECCCEEEEEHHHEE
TQTEFFEVSYRDDFSLDLDETKKAIEKYQPHLVFLANPNNPTGTLVDIETIKKLLAYDHL
EEEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHE
LVVDEAYVEFSGVSAIDLLKKYQNLVILRTFSKARALAGLRLGYLVASVDVVKEIIKVKN
EEEEHHHHHCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PYNVNVFSQIAGEVVLANEEVFQGEIKEIVAERERLYNQLASLGLKPVKSHANFILVEFG
CCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECC
EKAKKIHQELINHGILVRYLGGALANYLRITVGTPEENRQLLKKLGEIL
HHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA