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The map label for this gene is hisB

Identifier: 78042790

GI number: 78042790

Start: 963814

End: 964392

Strand: Direct

Name: hisB

Synonym: CHY_1087

Alternate gene names: 78042790

Gene position: 963814-964392 (Clockwise)

Preceding gene: 78044277

Following gene: 78043511

Centisome position: 40.13

GC content: 46.29

Gene sequence:

>579_bases
ATGAGGCGGGCCGAGGTACAACGAACAACATTAGAAACCATGATTAATGTGGAGTTTACAATGGACGGAAACGGGGAGTT
TTCCGGAACTTCAGGCCTTGGGTTTTTTGACCACATGCTCACCCTGTTTTGTAAATTTGGCGGGTTTAATTTAAATCTTT
CCTGCCAGGGAGACCTGGAGGTAGATGACCACCACACGGTGGAAGATATTGGTCTGGTTTTGGGGGAAGCGTTTTCTAAA
GCTTTAGGGGATAAAAAGGGAATTGCCCGCTTTGCCTCGGGTTTTTATCCGATGGATGAAGCATTAATGCTGATAGCGGT
TGATATTTCCGGACGGCCGTATCTTGCCTTTGAAGCTGACTTTCCGCCGGTTTTGGCAGGAAAGTTTAACTACCAGATGG
TAGAAGAGTTTTTACGCGGGTTTGTGCAAAAAGCCGGGATTACGTTGCATGTCCGGGAAATTTCGGGCAAAAACTTACAC
CATAAAGCCGAGGCAATTTTTAAAGGCTTGGGACGTACCTTAAAAGTTGCGGTTTCCGTCCAGGGGGATGAATTACCCTC
AACCAAAGGAGTGATTTAG

Upstream 100 bases:

>100_bases
TAGTGCGGTACTTGGGAGGAGCCCTTGCTAATTATTTACGGATAACCGTTGGTACACCGGAAGAAAACCGGCAACTTTTA
AAGAAACTGGGGGAAATCTT

Downstream 100 bases:

>100_bases
AAAGTGACGGTTGTGGTAGATTACGAAATGGGTAATCTTTTAAGTGTGACCAAGGCTTTAGAAGAACTGGGATATAAACC
TTCCGTTACTTCGGATCCCA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRRAEVQRTTLETMINVEFTMDGNGEFSGTSGLGFFDHMLTLFCKFGGFNLNLSCQGDLEVDDHHTVEDIGLVLGEAFSK
ALGDKKGIARFASGFYPMDEALMLIAVDISGRPYLAFEADFPPVLAGKFNYQMVEEFLRGFVQKAGITLHVREISGKNLH
HKAEAIFKGLGRTLKVAVSVQGDELPSTKGVI

Sequences:

>Translated_192_residues
MRRAEVQRTTLETMINVEFTMDGNGEFSGTSGLGFFDHMLTLFCKFGGFNLNLSCQGDLEVDDHHTVEDIGLVLGEAFSK
ALGDKKGIARFASGFYPMDEALMLIAVDISGRPYLAFEADFPPVLAGKFNYQMVEEFLRGFVQKAGITLHVREISGKNLH
HKAEAIFKGLGRTLKVAVSVQGDELPSTKGVI
>Mature_192_residues
MRRAEVQRTTLETMINVEFTMDGNGEFSGTSGLGFFDHMLTLFCKFGGFNLNLSCQGDLEVDDHHTVEDIGLVLGEAFSK
ALGDKKGIARFASGFYPMDEALMLIAVDISGRPYLAFEADFPPVLAGKFNYQMVEEFLRGFVQKAGITLHVREISGKNLH
HKAEAIFKGLGRTLKVAVSVQGDELPSTKGVI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=50, Blast_Score=188, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=163, Percent_Identity=45.398773006135, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CARHZ (Q3AD51)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359933.1
- HSSP:   P34047
- ProteinModelPortal:   Q3AD51
- SMR:   Q3AD51
- STRING:   Q3AD51
- GeneID:   3726885
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1087
- NMPDR:   fig|246194.3.peg.1134
- TIGR:   CHY_1087
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- BioCyc:   CHYD246194:CHY_1087-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21068; Mature: 21068

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAEVQRTTLETMINVEFTMDGNGEFSGTSGLGFFDHMLTLFCKFGGFNLNLSCQGDLE
CCCHHHHHHHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
VDDHHTVEDIGLVLGEAFSKALGDKKGIARFASGFYPMDEALMLIAVDISGRPYLAFEAD
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECC
FPPVLAGKFNYQMVEEFLRGFVQKAGITLHVREISGKNLHHKAEAIFKGLGRTLKVAVSV
CCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEE
QGDELPSTKGVI
CCCCCCCCCCCC
>Mature Secondary Structure
MRRAEVQRTTLETMINVEFTMDGNGEFSGTSGLGFFDHMLTLFCKFGGFNLNLSCQGDLE
CCCHHHHHHHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
VDDHHTVEDIGLVLGEAFSKALGDKKGIARFASGFYPMDEALMLIAVDISGRPYLAFEAD
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECC
FPPVLAGKFNYQMVEEFLRGFVQKAGITLHVREISGKNLHHKAEAIFKGLGRTLKVAVSV
CCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEE
QGDELPSTKGVI
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA