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The map label for this gene is hemL

Identifier: 78044254

GI number: 78044254

Start: 1078424

End: 1079722

Strand: Direct

Name: hemL

Synonym: CHY_1212

Alternate gene names: 78044254

Gene position: 1078424-1079722 (Clockwise)

Preceding gene: 78044427

Following gene: 78044763

Centisome position: 44.91

GC content: 44.11

Gene sequence:

>1299_bases
ATGCCTTTAAAAATCGATAGATCAATCGAAGCTTTTAGCGAAGCTAAGAAAGTTATTCCCGGAGGAGTTAATAGTCCCGT
TCGTGCTTTTAAATCGGTGGGCTTAAATCCGGTTTTTATTGAACGGGGCGAAGGCTCAAAAATTTACGATATTGACGGGA
ATTGTTATATTGATTACGTTGGCTCATGGGGTCCGCTTATTTTAGGGCATCGCCACCCCAAAGTGGAAGAAGCTTTAGCC
AATTGCTTAAAAAAAGGTACGAGTTTCGGGGCTCCAACTCTTTTGGAAACCGAGATGGCGGAAATTATTGTTAATGCTTT
TCCTGCAATGGATATGGTACGGATGGTAAACTCGGGTACCGAAGCAACCATGAGTGCCATCCGTTTGGCCCGGGGTTTTA
CCGGACGAAATAAAATTGTTAAATTTGAAGGTTGTTATCACGGCCATGCGGATTCTTTGTTGATTAAAGCAGGTTCTGGA
GCTTTAACCTTAGGTGTTCCTACAAGCCCCGGGGTACCGGCGAATATTGCCAACAACACGATAACTGCTCAATTTAATGA
CTTAGCTCTCTTAGAAGAAATATTTGCCCAGGAAGGTAATGATATTGCTGCCGTTATTTTAGAACCGGTGGCCGGAAACA
TGGGAGTAGTCCCGCCTAAGCCAGGCTTTTTAGAAGGTGTTCGGGAGCTTACCAGAAAATATGGTGCTTTGCTAATAATG
GACGAGGTTATGACCGGTTTTAGGGTTCACTGGGGTGGAGCTCAGGTTCTCTATAACGTCGAACCGGATATTACAACCCT
CGGAAAAATTATTGGTGGAGGCTTACCGGTAGGAGCTTATGGTGGCAGGCGGGAAATCATGGAAATGGTGGCACCGGCCG
GACCTGTTTATCAAGCAGGAACTCTTTCGGGTAATCCTTTGGCAATGACCGCCGGTATTGCCACGTTAACTGTTTTAAAG
GAAGAAGGGGTTTATGAGCAGTTAGAAGAAAAATCAAGTTATCTGGAAAGCGGTTTAAAAGAAGCGGCAAGAGCCGCGGG
CTTAAAGCTCTGGTTTAACCGGGTCGGATCGATGCTTTGCACTTTCTTTACCTCGGAGGAAGTGGTGGATTATAAAACTG
CTTGCACATCCGATACTCAAAAGTTTGCGGTGTTCTTTAAGACTCTCTTAGAAAATGGAATTTATATTGCGCCTTCGCAA
TTTGAAGCCATGTTTGTATCCCTTGCCCATTCCAAAGACGATTTAGATAAAACCATTGAAGCTTCATATAAGGCATTTAA
GGCTGCAGCAGAAAATTAA

Upstream 100 bases:

>100_bases
GGGCTCGGGCTTATTTCTACCATGATGGCGATTACATGGCTGAAGAGCCGTGGTGCCTATACCAGGGGCGTAAGGGATAT
TAAAAGTAAGGAGTGAGAGA

Downstream 100 bases:

>100_bases
TGGCAAAGAAAAACCCCTTGAAGTAAACCTTCAAGGGGTTTTTTCTCATAAATGGTGCGGCAGAGAGGATTTGAACCTCC
ACGGGTATAAACCCACTAGA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MPLKIDRSIEAFSEAKKVIPGGVNSPVRAFKSVGLNPVFIERGEGSKIYDIDGNCYIDYVGSWGPLILGHRHPKVEEALA
NCLKKGTSFGAPTLLETEMAEIIVNAFPAMDMVRMVNSGTEATMSAIRLARGFTGRNKIVKFEGCYHGHADSLLIKAGSG
ALTLGVPTSPGVPANIANNTITAQFNDLALLEEIFAQEGNDIAAVILEPVAGNMGVVPPKPGFLEGVRELTRKYGALLIM
DEVMTGFRVHWGGAQVLYNVEPDITTLGKIIGGGLPVGAYGGRREIMEMVAPAGPVYQAGTLSGNPLAMTAGIATLTVLK
EEGVYEQLEEKSSYLESGLKEAARAAGLKLWFNRVGSMLCTFFTSEEVVDYKTACTSDTQKFAVFFKTLLENGIYIAPSQ
FEAMFVSLAHSKDDLDKTIEASYKAFKAAAEN

Sequences:

>Translated_432_residues
MPLKIDRSIEAFSEAKKVIPGGVNSPVRAFKSVGLNPVFIERGEGSKIYDIDGNCYIDYVGSWGPLILGHRHPKVEEALA
NCLKKGTSFGAPTLLETEMAEIIVNAFPAMDMVRMVNSGTEATMSAIRLARGFTGRNKIVKFEGCYHGHADSLLIKAGSG
ALTLGVPTSPGVPANIANNTITAQFNDLALLEEIFAQEGNDIAAVILEPVAGNMGVVPPKPGFLEGVRELTRKYGALLIM
DEVMTGFRVHWGGAQVLYNVEPDITTLGKIIGGGLPVGAYGGRREIMEMVAPAGPVYQAGTLSGNPLAMTAGIATLTVLK
EEGVYEQLEEKSSYLESGLKEAARAAGLKLWFNRVGSMLCTFFTSEEVVDYKTACTSDTQKFAVFFKTLLENGIYIAPSQ
FEAMFVSLAHSKDDLDKTIEASYKAFKAAAEN
>Mature_431_residues
PLKIDRSIEAFSEAKKVIPGGVNSPVRAFKSVGLNPVFIERGEGSKIYDIDGNCYIDYVGSWGPLILGHRHPKVEEALAN
CLKKGTSFGAPTLLETEMAEIIVNAFPAMDMVRMVNSGTEATMSAIRLARGFTGRNKIVKFEGCYHGHADSLLIKAGSGA
LTLGVPTSPGVPANIANNTITAQFNDLALLEEIFAQEGNDIAAVILEPVAGNMGVVPPKPGFLEGVRELTRKYGALLIMD
EVMTGFRVHWGGAQVLYNVEPDITTLGKIIGGGLPVGAYGGRREIMEMVAPAGPVYQAGTLSGNPLAMTAGIATLTVLKE
EGVYEQLEEKSSYLESGLKEAARAAGLKLWFNRVGSMLCTFFTSEEVVDYKTACTSDTQKFAVFFKTLLENGIYIAPSQF
EAMFVSLAHSKDDLDKTIEASYKAFKAAAEN

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=334, Percent_Identity=34.7305389221557, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI13994255, Length=336, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI37574042, Length=326, Percent_Identity=26.9938650306748, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI24119277, Length=323, Percent_Identity=29.4117647058824, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI226442705, Length=325, Percent_Identity=26.4615384615385, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=31.3846153846154, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442709, Length=294, Percent_Identity=27.5510204081633, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786349, Length=423, Percent_Identity=58.3924349881797, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1789016, Length=349, Percent_Identity=31.5186246418338, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI145693181, Length=314, Percent_Identity=33.4394904458599, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788044, Length=323, Percent_Identity=31.8885448916409, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789759, Length=314, Percent_Identity=30.8917197452229, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787560, Length=366, Percent_Identity=29.5081967213115, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786991, Length=340, Percent_Identity=27.6470588235294, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=341, Percent_Identity=30.791788856305, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=316, Percent_Identity=33.2278481012658, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=338, Percent_Identity=30.4733727810651, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=161, Percent_Identity=38.5093167701863, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=446, Percent_Identity=23.3183856502242, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=324, Percent_Identity=29.9382716049383, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=325, Percent_Identity=28.6153846153846, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=306, Percent_Identity=31.0457516339869, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161085790, Length=346, Percent_Identity=29.7687861271676, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28574759, Length=346, Percent_Identity=29.7687861271676, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356575, Length=347, Percent_Identity=29.971181556196, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_CARHZ (Q3ACS9)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_360055.1
- ProteinModelPortal:   Q3ACS9
- SMR:   Q3ACS9
- STRING:   Q3ACS9
- GeneID:   3727371
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1212
- NMPDR:   fig|246194.3.peg.1261
- TIGR:   CHY_1212
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- ProtClustDB:   PRK00062
- BioCyc:   CHYD246194:CHY_1212-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46366; Mature: 46235

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKIDRSIEAFSEAKKVIPGGVNSPVRAFKSVGLNPVFIERGEGSKIYDIDGNCYIDYV
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEEEC
GSWGPLILGHRHPKVEEALANCLKKGTSFGAPTLLETEMAEIIVNAFPAMDMVRMVNSGT
CCCCCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EATMSAIRLARGFTGRNKIVKFEGCYHGHADSLLIKAGSGALTLGVPTSPGVPANIANNT
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCE
ITAQFNDLALLEEIFAQEGNDIAAVILEPVAGNMGVVPPKPGFLEGVRELTRKYGALLIM
EEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEE
DEVMTGFRVHWGGAQVLYNVEPDITTLGKIIGGGLPVGAYGGRREIMEMVAPAGPVYQAG
HHHHCCEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECC
TLSGNPLAMTAGIATLTVLKEEGVYEQLEEKSSYLESGLKEAARAAGLKLWFNRVGSMLC
CCCCCCEEEEHHHHHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFFTSEEVVDYKTACTSDTQKFAVFFKTLLENGIYIAPSQFEAMFVSLAHSKDDLDKTIE
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHCCHHHHHHHHH
ASYKAFKAAAEN
HHHHHHHHHCCC
>Mature Secondary Structure 
PLKIDRSIEAFSEAKKVIPGGVNSPVRAFKSVGLNPVFIERGEGSKIYDIDGNCYIDYV
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEEEC
GSWGPLILGHRHPKVEEALANCLKKGTSFGAPTLLETEMAEIIVNAFPAMDMVRMVNSGT
CCCCCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EATMSAIRLARGFTGRNKIVKFEGCYHGHADSLLIKAGSGALTLGVPTSPGVPANIANNT
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCE
ITAQFNDLALLEEIFAQEGNDIAAVILEPVAGNMGVVPPKPGFLEGVRELTRKYGALLIM
EEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEE
DEVMTGFRVHWGGAQVLYNVEPDITTLGKIIGGGLPVGAYGGRREIMEMVAPAGPVYQAG
HHHHCCEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECC
TLSGNPLAMTAGIATLTVLKEEGVYEQLEEKSSYLESGLKEAARAAGLKLWFNRVGSMLC
CCCCCCEEEEHHHHHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFFTSEEVVDYKTACTSDTQKFAVFFKTLLENGIYIAPSQFEAMFVSLAHSKDDLDKTIE
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHCCHHHHHHHHH
ASYKAFKAAAEN
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA