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The map label for this gene is mhpT [H]

Identifier: 77461931

GI number: 77461931

Start: 6400934

End: 6402154

Strand: Reverse

Name: mhpT [H]

Synonym: Pfl01_5712

Alternate gene names: 77461931

Gene position: 6402154-6400934 (Counterclockwise)

Preceding gene: 77461932

Following gene: 77461930

Centisome position: 99.44

GC content: 64.37

Gene sequence:

>1221_bases
ATGAGTGAACAGGCAATCGGCACGGCGACACCCAGGACCTCGACAGATCGTGCCGCGTGGACTGTGGTGGGACTGTGCAT
GCTATTCAATGTAATCGACGGCCTGGATGCGATGGTCATGGTGTTCACGGTGCACCGCGTGGCGGCGCTGTGGTCATTGA
GCGCGGCCCAGATGGGCCTGCTGCTCAGCGCCAGTCTGGTGGGCATGGCAGCCGGCTCGTTGTGTGTCGGTGCGATGACG
CAGCGCTTCGGGCGGCGTCCCGTTGTGCTGGCCAGCCTGGCGCTCAGCGGCATGACAATGCTATTGGGGTTCTGGAGTCA
GGAGCTTTACAGCCTGCTATGCCTGCGTATGCTCACCGGTCTCGGCGTGGGCGCTGTACTGGTGTGCGCCAACGTACTCA
CCCACGACCATGCGCCACCGCGCCATCGCAGCCTCGGGATTGCCCTGCAATCCGTGGCCTTTGCCCTGGGCGTGACCCTG
GGCGGTCTGCTTGCGCATCGGCTCAACGACAGCCTCGGCTGGCGTTATGTGTTTCTGGCCGGGGGAGTGCTGACGTTGCT
CTTGGCTGCGATCGGCGCGCGATGGCTGCGTGAGTCCGCCTCACCGCTGGCGGTCGAAAAGACTGCCCCGCGCTATCGCG
ATCTGATCAGCCGCGCGCGCTGGCAGTCGACCTGCACCCTGGCGGTCGTGTGTTTCTTGCTGATGTTCGGTTTTTACTTC
GTGATGAGCTGGACGCCCATGCTGCTAACACTGGGAGGCTTTTCCGAACGGCACGGCATCACGGGCGGCATGCTGCTTAC
TATCGGCGGTATGTGCGGCGCATTGCTGCTAGGCCTTGGTGCCAATCGCCTGGGCTGCCATCGGTTGCTGGGGGCGGGGC
TGCTGCTGAATGCCTTGCTGATGCTGTCGATGGTCTCGGCCGCCCATGTCCCGGTGTTGGCAGTAGTGATGGGGTTTACG
GTGGGGTTTTCGCTGTACGCCGCCATCGCCGCGCTGTTCGTGATGGCCCCCCAGGCGTTCGATAGCGCGGTGCGTACTCG
GGGCGTGGGCCTGGTGCTGGCTACTGGGCGGCTGGGCGCGATCCTGTCGCCGACGGTAGCCGGTGTGTTGCTCGACGCCC
AGTGGCGCCCTCAAGACCTGTTCACCTTCTATGCGGGCACCCAACTGTTGGCCGTTCTGCTGATCGGGCGAAACCGTCGG
CCTACGCCTGAGGCAGGATGA

Upstream 100 bases:

>100_bases
TCCCGTTGCACGAAGATGCCGATCGATACCTTTGTATGACTTGCCAGCGTCGTCGCCCGTTGCTGCCATCCACTTTCGAT
AAGAACAGGACCCGCTACAT

Downstream 100 bases:

>100_bases
TCAGCTTGCCCGTCGTCCGGCGCGACTCGATATCCCGATGGGCCTGATGCGCCTGCACCAAGGGGGTAACGCTGGCCGAT
ACTGACGTTGAGCCTGCCAG

Product: general substrate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSEQAIGTATPRTSTDRAAWTVVGLCMLFNVIDGLDAMVMVFTVHRVAALWSLSAAQMGLLLSASLVGMAAGSLCVGAMT
QRFGRRPVVLASLALSGMTMLLGFWSQELYSLLCLRMLTGLGVGAVLVCANVLTHDHAPPRHRSLGIALQSVAFALGVTL
GGLLAHRLNDSLGWRYVFLAGGVLTLLLAAIGARWLRESASPLAVEKTAPRYRDLISRARWQSTCTLAVVCFLLMFGFYF
VMSWTPMLLTLGGFSERHGITGGMLLTIGGMCGALLLGLGANRLGCHRLLGAGLLLNALLMLSMVSAAHVPVLAVVMGFT
VGFSLYAAIAALFVMAPQAFDSAVRTRGVGLVLATGRLGAILSPTVAGVLLDAQWRPQDLFTFYAGTQLLAVLLIGRNRR
PTPEAG

Sequences:

>Translated_406_residues
MSEQAIGTATPRTSTDRAAWTVVGLCMLFNVIDGLDAMVMVFTVHRVAALWSLSAAQMGLLLSASLVGMAAGSLCVGAMT
QRFGRRPVVLASLALSGMTMLLGFWSQELYSLLCLRMLTGLGVGAVLVCANVLTHDHAPPRHRSLGIALQSVAFALGVTL
GGLLAHRLNDSLGWRYVFLAGGVLTLLLAAIGARWLRESASPLAVEKTAPRYRDLISRARWQSTCTLAVVCFLLMFGFYF
VMSWTPMLLTLGGFSERHGITGGMLLTIGGMCGALLLGLGANRLGCHRLLGAGLLLNALLMLSMVSAAHVPVLAVVMGFT
VGFSLYAAIAALFVMAPQAFDSAVRTRGVGLVLATGRLGAILSPTVAGVLLDAQWRPQDLFTFYAGTQLLAVLLIGRNRR
PTPEAG
>Mature_405_residues
SEQAIGTATPRTSTDRAAWTVVGLCMLFNVIDGLDAMVMVFTVHRVAALWSLSAAQMGLLLSASLVGMAAGSLCVGAMTQ
RFGRRPVVLASLALSGMTMLLGFWSQELYSLLCLRMLTGLGVGAVLVCANVLTHDHAPPRHRSLGIALQSVAFALGVTLG
GLLAHRLNDSLGWRYVFLAGGVLTLLLAAIGARWLRESASPLAVEKTAPRYRDLISRARWQSTCTLAVVCFLLMFGFYFV
MSWTPMLLTLGGFSERHGITGGMLLTIGGMCGALLLGLGANRLGCHRLLGAGLLLNALLMLSMVSAAHVPVLAVVMGFTV
GFSLYAAIAALFVMAPQAFDSAVRTRGVGLVLATGRLGAILSPTVAGVLLDAQWRPQDLFTFYAGTQLLAVLLIGRNRRP
TPEAG

Specific function: Could be a transporter for 3-phenylpropionate (hydrocinnamic acid) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=393, Percent_Identity=23.9185750636132, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI87081723, Length=351, Percent_Identity=31.9088319088319, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87082404, Length=379, Percent_Identity=22.1635883905013, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786229, Length=362, Percent_Identity=22.9281767955801, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082159, Length=380, Percent_Identity=24.2105263157895, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319718, Length=158, Percent_Identity=29.746835443038, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42932; Mature: 42801

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SEQAIGTATPRTSTDRAAWTVVGLCMLFNVIDGLDAMVMVFTVHRVAALWSLSAAQMGL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSASLVGMAAGSLCVGAMTQRFGRRPVVLASLALSGMTMLLGFWSQELYSLLCLRMLTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGVGAVLVCANVLTHDHAPPRHRSLGIALQSVAFALGVTLGGLLAHRLNDSLGWRYVFLA
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH
GGVLTLLLAAIGARWLRESASPLAVEKTAPRYRDLISRARWQSTCTLAVVCFLLMFGFYF
HHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMSWTPMLLTLGGFSERHGITGGMLLTIGGMCGALLLGLGANRLGCHRLLGAGLLLNALL
HHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MLSMVSAAHVPVLAVVMGFTVGFSLYAAIAALFVMAPQAFDSAVRTRGVGLVLATGRLGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEEECCCCCC
ILSPTVAGVLLDAQWRPQDLFTFYAGTQLLAVLLIGRNRRPTPEAG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]