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The map label for this gene is uhpC [H]

Identifier: 77459902

GI number: 77459902

Start: 4164159

End: 4165484

Strand: Reverse

Name: uhpC [H]

Synonym: Pfl01_3680

Alternate gene names: 77459902

Gene position: 4165484-4164159 (Counterclockwise)

Preceding gene: 77459904

Following gene: 77459901

Centisome position: 64.7

GC content: 62.9

Gene sequence:

>1326_bases
ATGAACAAGCACATCGGCACCCTTGCGCGTTGGCGCATGCAGATCTTCGCTGTCACCTGGCTCGCTTACGCCGCGTTCTA
TTTCACCCGCAAAGCCTTTTCGGTGGCCAAACTGGGCATCGCCGAAGACCCGAGTTTCACCCTCGACAAAATGGCCATGG
CCAACCTCGACGCGATTTACCTGGCGGCCTACGCCATCGGCCAGTTCACCTGGGGCATGCTCGCCGACCGCTTCGGCCCA
CGGATCGTGGTGCTTGGCGGGTTGCTGATTTCCGCTGCGGCAGCGCTGGTGATGGGCAGTTTTGCGACCTTGCCGATCTT
CGCCACCTGCATGTTGATTCAGGGCCTGGCGCAGTCCACCGGTTGGTCGGGGTTGTGCAAGAACCTCGGTAGTTTTTTCC
CTTCGGAACAGCGCGGGCGAGTGCTCGGGTTGTGGAGTTCCTGCTACGCCTTCGGTGGATTGGTGGCCTCGCCGTTCGCC
GGTTGGTGGGCGTACACGCTGGTCGGCACCTGGCACGCGGCGTTCATTTCCAGTGCGGCGGTGGTCGCGGCGGTGGCGGT
GTTGTTCTTCATCTTTCAGCGCAACAAACCGGAAGATGTCGGCCTGCCGGCGGTGGAACCGGAACCGGTCATCAGTGCCG
AGGAAGCCGAAGCCAACAGCAAACTCAGCGTGTGGGAACCGCTCAAGGAAATCCTGCGTAACCGCACGGTGCTGGTGTTG
GGTCTGGCGTATTTCCTGTTGAAACCGGCGCGTTACGCGATTCTGCTGTGGGGCCCGGTGATCGTGTTCGAACAGATGCC
TTCGGTCGGCAAGGTTGGCGCGGCGATCATTCCCACGGCGTTTGAACTGGCCGGTCTGCTGGGTCCGATCATGATCGGCC
TGGCCTCGGACAAACTGTTCGGTGCCCGACGCATGCCGGCCTGCGTGTTGAGTCTGCTGGCGCTGACCGTGACCCTTGCG
CTGTTCATGGGCGCCTTGCACACCGGCAGCGTGATGCTGGTGGTCGCATTGTTGTTCGTGATGGGCCTGACCCTGTACGG
CCCGGACTCAATGATCAGCGGCGCGGCCGCGATCGATTTCGGCAAGGCCAAGGCCGGCGCCACGGCGGCGGGATTCGTCA
ACGGCTGCGGCTCGGTCGGTGCGGTGCTCGGTGGTTTGCTGCCGGGTTACTTCGACTCGGTGACGGTGTTCATCGTGTTC
GCCGGTTGTGCGCTGTTCTCGGCGCTGGTGCTGATTCCACACTGGAACAGCCGCCCGGTCGGCGTCATGGAACCGCGCGC
CTACGTGCCCAATCGTGCCCTGACCGTCAAACCCCTGCGTAACTGA

Upstream 100 bases:

>100_bases
CCGAAGGGACGGGGTGATATCGCAGTGCTCAACAATAAAAAACACAGGCGTTTACTTATCGATTCTGCCGGCACACTCAC
ACCCTGAGGTCAGAACCACA

Downstream 100 bases:

>100_bases
AACCCCTTGTCTCGCGGCCTGCTGCGGCACTCGCGGCAGGCTGTGTCGTGGCCGACTGACTGGAGAATTTTCATGAGACC
GTTTTGGCTGGAGCAGGCTT

Product: general substrate transporter

Products: Proton [Cytoplasm]; glycerol-3-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNKHIGTLARWRMQIFAVTWLAYAAFYFTRKAFSVAKLGIAEDPSFTLDKMAMANLDAIYLAAYAIGQFTWGMLADRFGP
RIVVLGGLLISAAAALVMGSFATLPIFATCMLIQGLAQSTGWSGLCKNLGSFFPSEQRGRVLGLWSSCYAFGGLVASPFA
GWWAYTLVGTWHAAFISSAAVVAAVAVLFFIFQRNKPEDVGLPAVEPEPVISAEEAEANSKLSVWEPLKEILRNRTVLVL
GLAYFLLKPARYAILLWGPVIVFEQMPSVGKVGAAIIPTAFELAGLLGPIMIGLASDKLFGARRMPACVLSLLALTVTLA
LFMGALHTGSVMLVVALLFVMGLTLYGPDSMISGAAAIDFGKAKAGATAAGFVNGCGSVGAVLGGLLPGYFDSVTVFIVF
AGCALFSALVLIPHWNSRPVGVMEPRAYVPNRALTVKPLRN

Sequences:

>Translated_441_residues
MNKHIGTLARWRMQIFAVTWLAYAAFYFTRKAFSVAKLGIAEDPSFTLDKMAMANLDAIYLAAYAIGQFTWGMLADRFGP
RIVVLGGLLISAAAALVMGSFATLPIFATCMLIQGLAQSTGWSGLCKNLGSFFPSEQRGRVLGLWSSCYAFGGLVASPFA
GWWAYTLVGTWHAAFISSAAVVAAVAVLFFIFQRNKPEDVGLPAVEPEPVISAEEAEANSKLSVWEPLKEILRNRTVLVL
GLAYFLLKPARYAILLWGPVIVFEQMPSVGKVGAAIIPTAFELAGLLGPIMIGLASDKLFGARRMPACVLSLLALTVTLA
LFMGALHTGSVMLVVALLFVMGLTLYGPDSMISGAAAIDFGKAKAGATAAGFVNGCGSVGAVLGGLLPGYFDSVTVFIVF
AGCALFSALVLIPHWNSRPVGVMEPRAYVPNRALTVKPLRN
>Mature_441_residues
MNKHIGTLARWRMQIFAVTWLAYAAFYFTRKAFSVAKLGIAEDPSFTLDKMAMANLDAIYLAAYAIGQFTWGMLADRFGP
RIVVLGGLLISAAAALVMGSFATLPIFATCMLIQGLAQSTGWSGLCKNLGSFFPSEQRGRVLGLWSSCYAFGGLVASPFA
GWWAYTLVGTWHAAFISSAAVVAAVAVLFFIFQRNKPEDVGLPAVEPEPVISAEEAEANSKLSVWEPLKEILRNRTVLVL
GLAYFLLKPARYAILLWGPVIVFEQMPSVGKVGAAIIPTAFELAGLLGPIMIGLASDKLFGARRMPACVLSLLALTVTLA
LFMGALHTGSVMLVVALLFVMGLTLYGPDSMISGAAAIDFGKAKAGATAAGFVNGCGSVGAVLGGLLPGYFDSVTVFIVF
AGCALFSALVLIPHWNSRPVGVMEPRAYVPNRALTVKPLRN

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI38093649, Length=438, Percent_Identity=26.9406392694064, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI46361976, Length=435, Percent_Identity=26.8965517241379, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223717983, Length=438, Percent_Identity=26.9406392694064, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI256219598, Length=385, Percent_Identity=27.012987012987, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4503847, Length=385, Percent_Identity=27.012987012987, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI256219483, Length=385, Percent_Identity=27.012987012987, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI49619231, Length=462, Percent_Identity=24.2424242424242, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI256219543, Length=407, Percent_Identity=26.044226044226, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI14150047, Length=310, Percent_Identity=25.4838709677419, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI256219564, Length=315, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788573, Length=423, Percent_Identity=26.7139479905437, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082310, Length=419, Percent_Identity=28.6396181384248, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI2367259, Length=370, Percent_Identity=27.027027027027, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789152, Length=314, Percent_Identity=23.5668789808917, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789515, Length=433, Percent_Identity=24.4803695150115, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI2367379, Length=250, Percent_Identity=26, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI2367193, Length=267, Percent_Identity=25.0936329588015, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI133901854, Length=429, Percent_Identity=26.8065268065268, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI133901856, Length=429, Percent_Identity=26.8065268065268, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17564202, Length=414, Percent_Identity=26.5700483091787, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI133930953, Length=418, Percent_Identity=23.6842105263158, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17542316, Length=408, Percent_Identity=24.0196078431373, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17564204, Length=346, Percent_Identity=26.0115606936416, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24656866, Length=448, Percent_Identity=25, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45550478, Length=448, Percent_Identity=25, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656861, Length=448, Percent_Identity=25.2232142857143, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46878; Mature: 46878

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glycerol-3-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glycerol-3-phosphate [Periplasm] = Proton [Cytoplasm] + glycerol-3-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]