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The map label for this gene is lpxH

Identifier: 77459863

GI number: 77459863

Start: 4117332

End: 4118078

Strand: Direct

Name: lpxH

Synonym: Pfl01_3641

Alternate gene names: 77459863

Gene position: 4117332-4118078 (Clockwise)

Preceding gene: 77459862

Following gene: 77459871

Centisome position: 63.95

GC content: 60.91

Gene sequence:

>747_bases
GTGATATTGCTGATTTCAGACTTGCATCTGGAAGAGGAGCGCCCGGACATTACCCGGGCGTTTCTGGATTTGCTCGCCGG
ACGCGCCCGCTCGGCGAGTGCGTTGTACATTCTGGGCGACTTTTTCGAAGCGTGGATTGGCGACGACGCCATGACCCCCT
TCCAGCGTTCCATCTGCCAGGCCCTGCGCGAACTCAGCGACAGCGGCACGGCCATTTTTCTGATGCACGGCAATCGCGAC
TTCATGCTCGGCAAGGCCTTCTGCAAGCAGGCCGGCTGCACGCTGTTGAAGGATCCGAGTGTCGTGCAGTTTTACGGCGA
ACCGGTATTGCTGATGCACGGCGACAGCCTGTGCACCCGCGACGAATCCTACATGAAGCTGCGCCGCTATCTGCGCAACC
CGCTCAGCCTGTTCATCCTGCGCAACCTGCCCTTGCGCACCCGGCACAAGCTCGCGCGCAAGTTGCGCAGCGAAAGCCGG
GCGCAGACGCGGATGAAGGCCAATGACATCGTCGATGTCACGCCGGAGGAAATTCCGCGGATCATGCAGGAATACGGGGT
GAAAACCCTGGTTCACGGGCACACCCATCGCCCGGCGATCCACAAGTTGCAGATCGGCGATCAGGCGGCGAAGCGGATTG
TGCTGGGGGATTGGGATCGTCAGGGTTGGGCGTTGCAGGTGGATGAGAACGGGTTTGCGTTAGCGCCGTTTGATTTTGCG
CCACCGTTGGCATTGCCGCACGGCTGA

Upstream 100 bases:

>100_bases
TTGTCGACAAGATCGAAGGCGTTTCCACCACGTCCAAGGCAGGCCACCAGGACGTACCCGCAGACGACGTGATCATCGAG
AAAGCCGAGATCATCGAAGC

Downstream 100 bases:

>100_bases
AGATCGCTACCCCCTCACCCCAGCCCTCTCCCCCAAGGGGGCGAGGGGGAAAGGGAGCCGATATTCGTAGTTTTCAGAAT
CTGAGCTCGACTCTGTTTCG

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MILLISDLHLEEERPDITRAFLDLLAGRARSASALYILGDFFEAWIGDDAMTPFQRSICQALRELSDSGTAIFLMHGNRD
FMLGKAFCKQAGCTLLKDPSVVQFYGEPVLLMHGDSLCTRDESYMKLRRYLRNPLSLFILRNLPLRTRHKLARKLRSESR
AQTRMKANDIVDVTPEEIPRIMQEYGVKTLVHGHTHRPAIHKLQIGDQAAKRIVLGDWDRQGWALQVDENGFALAPFDFA
PPLALPHG

Sequences:

>Translated_248_residues
MILLISDLHLEEERPDITRAFLDLLAGRARSASALYILGDFFEAWIGDDAMTPFQRSICQALRELSDSGTAIFLMHGNRD
FMLGKAFCKQAGCTLLKDPSVVQFYGEPVLLMHGDSLCTRDESYMKLRRYLRNPLSLFILRNLPLRTRHKLARKLRSESR
AQTRMKANDIVDVTPEEIPRIMQEYGVKTLVHGHTHRPAIHKLQIGDQAAKRIVLGDWDRQGWALQVDENGFALAPFDFA
PPLALPHG
>Mature_248_residues
MILLISDLHLEEERPDITRAFLDLLAGRARSASALYILGDFFEAWIGDDAMTPFQRSICQALRELSDSGTAIFLMHGNRD
FMLGKAFCKQAGCTLLKDPSVVQFYGEPVLLMHGDSLCTRDESYMKLRRYLRNPLSLFILRNLPLRTRHKLARKLRSESR
AQTRMKANDIVDVTPEEIPRIMQEYGVKTLVHGHTHRPAIHKLQIGDQAAKRIVLGDWDRQGWALQVDENGFALAPFDFA
PPLALPHG

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=237, Percent_Identity=44.7257383966245, Blast_Score=217, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_PSEPF (Q3KA25)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_349370.1
- ProteinModelPortal:   Q3KA25
- STRING:   Q3KA25
- GeneID:   3715068
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_3641
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   PFLU205922:PFL_3641-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 28165; Mature: 28165

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLISDLHLEEERPDITRAFLDLLAGRARSASALYILGDFFEAWIGDDAMTPFQRSICQ
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHH
ALRELSDSGTAIFLMHGNRDFMLGKAFCKQAGCTLLKDPSVVQFYGEPVLLMHGDSLCTR
HHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCEEECCCCEEEECCCEEEEEECCCHHCC
DESYMKLRRYLRNPLSLFILRNLPLRTRHKLARKLRSESRAQTRMKANDIVDVTPEEIPR
CHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHH
IMQEYGVKTLVHGHTHRPAIHKLQIGDQAAKRIVLGDWDRQGWALQVDENGFALAPFDFA
HHHHHCCCEEECCCCCCCCCEEEECCHHHHCEEEEECCCCCCCEEEECCCCCEECCCCCC
PPLALPHG
CCCCCCCC
>Mature Secondary Structure
MILLISDLHLEEERPDITRAFLDLLAGRARSASALYILGDFFEAWIGDDAMTPFQRSICQ
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHH
ALRELSDSGTAIFLMHGNRDFMLGKAFCKQAGCTLLKDPSVVQFYGEPVLLMHGDSLCTR
HHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCEEECCCCEEEECCCEEEEEECCCHHCC
DESYMKLRRYLRNPLSLFILRNLPLRTRHKLARKLRSESRAQTRMKANDIVDVTPEEIPR
CHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHH
IMQEYGVKTLVHGHTHRPAIHKLQIGDQAAKRIVLGDWDRQGWALQVDENGFALAPFDFA
HHHHHCCCEEECCCCCCCCCEEEECCHHHHCEEEEECCCCCCCEEEECCCCCEECCCCCC
PPLALPHG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA