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The map label for this gene is cyp18 [H]

Identifier: 77459862

GI number: 77459862

Start: 4116829

End: 4117335

Strand: Direct

Name: cyp18 [H]

Synonym: Pfl01_3640

Alternate gene names: 77459862

Gene position: 4116829-4117335 (Clockwise)

Preceding gene: 77459858

Following gene: 77459863

Centisome position: 63.94

GC content: 55.42

Gene sequence:

>507_bases
ATGACTCAAGTTAAATTGACCACCAACTTCGGTGACATCGTCATCGAACTGAACGCTGAAAAGGCGCCTCTCACCACCGC
CAACTTCATCGAATACGTCAAGAAAGGTCACTACGAGAACGTCGTGTTCCACCGCGTCATCAAAGGCTTCATGATCCAGG
GCGGCGGTTTCGAGCCAGGCATGAAAGAAAAGAAAGACAAGAGCCCGAGCATCCAGAACGAAGCCGACAACGGTCTGAAG
AACGACAAGTACACCATCGCGATGGCCCGTACCATGGACCCGCATTCGGCTTCGGCGCAGTTCTTCATCAACGCCTCCGA
CAACAGCTTCCTGAACCACACCGCCAAGACCGCCCAGGGCTGGGGTTATGCCGTGTTCGGTAAAGTGGTTGCGGGCACCG
ACGTTGTCGACAAGATCGAAGGCGTTTCCACCACGTCCAAGGCAGGCCACCAGGACGTACCCGCAGACGACGTGATCATC
GAGAAAGCCGAGATCATCGAAGCGTGA

Upstream 100 bases:

>100_bases
GCCTGTCACGCTAAACTGCGCACCTTGGCCCTCACGGGCTGAACCGGTACGGGGCCCAAATGTCCCAATACCCACGAATT
CCTTATAAAGAGCATCGATC

Downstream 100 bases:

>100_bases
TATTGCTGATTTCAGACTTGCATCTGGAAGAGGAGCGCCCGGACATTACCCGGGCGTTTCTGGATTTGCTCGCCGGACGC
GCCCGCTCGGCGAGTGCGTT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTQVKLTTNFGDIVIELNAEKAPLTTANFIEYVKKGHYENVVFHRVIKGFMIQGGGFEPGMKEKKDKSPSIQNEADNGLK
NDKYTIAMARTMDPHSASAQFFINASDNSFLNHTAKTAQGWGYAVFGKVVAGTDVVDKIEGVSTTSKAGHQDVPADDVII
EKAEIIEA

Sequences:

>Translated_168_residues
MTQVKLTTNFGDIVIELNAEKAPLTTANFIEYVKKGHYENVVFHRVIKGFMIQGGGFEPGMKEKKDKSPSIQNEADNGLK
NDKYTIAMARTMDPHSASAQFFINASDNSFLNHTAKTAQGWGYAVFGKVVAGTDVVDKIEGVSTTSKAGHQDVPADDVII
EKAEIIEA
>Mature_167_residues
TQVKLTTNFGDIVIELNAEKAPLTTANFIEYVKKGHYENVVFHRVIKGFMIQGGGFEPGMKEKKDKSPSIQNEADNGLKN
DKYTIAMARTMDPHSASAQFFINASDNSFLNHTAKTAQGWGYAVFGKVVAGTDVVDKIEGVSTTSKAGHQDVPADDVIIE
KAEIIEA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=34.7560975609756, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=33.1210191082803, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=30.3030303030303, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=60.9756097560976, Blast_Score=207, Evalue=3e-55,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=53.6585365853659, Blast_Score=176, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=32.5301204819277, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=147, Percent_Identity=34.0136054421769, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=159, Percent_Identity=36.4779874213836, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=163, Percent_Identity=30.6748466257669, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19922376, Length=172, Percent_Identity=29.6511627906977, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19922912, Length=160, Percent_Identity=35.625, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18310; Mature: 18179

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVKLTTNFGDIVIELNAEKAPLTTANFIEYVKKGHYENVVFHRVIKGFMIQGGGFEPG
CCEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCC
MKEKKDKSPSIQNEADNGLKNDKYTIAMARTMDPHSASAQFFINASDNSFLNHTAKTAQG
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHCCC
WGYAVFGKVVAGTDVVDKIEGVSTTSKAGHQDVPADDVIIEKAEIIEA
CCEEEHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCEEECHHHHHCC
>Mature Secondary Structure 
TQVKLTTNFGDIVIELNAEKAPLTTANFIEYVKKGHYENVVFHRVIKGFMIQGGGFEPG
CEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCC
MKEKKDKSPSIQNEADNGLKNDKYTIAMARTMDPHSASAQFFINASDNSFLNHTAKTAQG
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHCCC
WGYAVFGKVVAGTDVVDKIEGVSTTSKAGHQDVPADDVIIEKAEIIEA
CCEEEHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCEEECHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]