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The map label for this gene is czcR [H]

Identifier: 77459846

GI number: 77459846

Start: 4098090

End: 4098764

Strand: Direct

Name: czcR [H]

Synonym: Pfl01_3624

Alternate gene names: 77459846

Gene position: 4098090-4098764 (Clockwise)

Preceding gene: 77459840

Following gene: 77459847

Centisome position: 63.65

GC content: 60.74

Gene sequence:

>675_bases
ATGCGAATCCTTGTCGTCGAGGACGAGCTTAAAGCTGCCGAATACTTGCATCAGGGCCTGACCGAAAGTGGTTATATCGT
TGATCACGCGGTCAATGGCGCGGATGGTTTGCACCTGGCGCAACAACAGGTTTATGACCTGATCATCCTCGATGTGAACC
TGCCGGAACTAGACGGCTGGAGCGTGCTGGAACAACTGCGTCGCACCCACTCAACCCGGGTGATGATGCTCACCGCACGC
GGGCGGCTGGCGGACAAGATCCGGGGTCTGGATCTGGGCGCCGATGATTATCTGGTCAAGCCGTTCGAGTTCCCGGAACT
GCTGGCCAGGGTGCGCACGTTGATGCGGCGCAGCGAGAACATCCCGGTGCCGCAGGTGCTCAAGGTTGCCGATCTGGAAC
TCGATCCGGGCCGTCACCGGGCGTTTCGTGGCACGCAGCGCATCGACCTGACCACCAAGGAATTCGCCCTGCTGCACCTG
CTGATGCGCCAGTCCGGCGAAGTGCTGACCCGCACCCAGATCATCTCGCTGGTGTGGGACATGAATTTCGACTGCGACAC
CAACGTGGTCGAAGTCTCGATCCGCCGCTTGCGGGCGAAGATCGACGACCCGTTCGACAGCAAACTGATCCACACCTTGC
GCGGCGTCGGCTATGTGCTGGAGGCGCGGGAATGA

Upstream 100 bases:

>100_bases
CGCCACTCAGTTACGAAGTCCGTCAGGAAGTCCCTACAAAAAACTGCAACTTCCAGACTCACTTAGTTAAATACCCATTC
ATTAAAAGTGGTGAAACATC

Downstream 100 bases:

>100_bases
AGCCGGCCAGCCTGTCGCTACGGCTGGGTCTGACGGTCAGCATTCTGGGCGCATTGCTGGTGGTGTTCCTGGCGATCCTC
GCGTATTTCGCCCTGACCCA

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILVVEDELKAAEYLHQGLTESGYIVDHAVNGADGLHLAQQQVYDLIILDVNLPELDGWSVLEQLRRTHSTRVMMLTAR
GRLADKIRGLDLGADDYLVKPFEFPELLARVRTLMRRSENIPVPQVLKVADLELDPGRHRAFRGTQRIDLTTKEFALLHL
LMRQSGEVLTRTQIISLVWDMNFDCDTNVVEVSIRRLRAKIDDPFDSKLIHTLRGVGYVLEARE

Sequences:

>Translated_224_residues
MRILVVEDELKAAEYLHQGLTESGYIVDHAVNGADGLHLAQQQVYDLIILDVNLPELDGWSVLEQLRRTHSTRVMMLTAR
GRLADKIRGLDLGADDYLVKPFEFPELLARVRTLMRRSENIPVPQVLKVADLELDPGRHRAFRGTQRIDLTTKEFALLHL
LMRQSGEVLTRTQIISLVWDMNFDCDTNVVEVSIRRLRAKIDDPFDSKLIHTLRGVGYVLEARE
>Mature_224_residues
MRILVVEDELKAAEYLHQGLTESGYIVDHAVNGADGLHLAQQQVYDLIILDVNLPELDGWSVLEQLRRTHSTRVMMLTAR
GRLADKIRGLDLGADDYLVKPFEFPELLARVRTLMRRSENIPVPQVLKVADLELDPGRHRAFRGTQRIDLTTKEFALLHL
LMRQSGEVLTRTQIISLVWDMNFDCDTNVVEVSIRRLRAKIDDPFDSKLIHTLRGVGYVLEARE

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=53.1531531531532, Blast_Score=241, Evalue=2e-65,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=50.4504504504504, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=37.3333333333333, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=39.3665158371041, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=38.4279475982533, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.8017621145374, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.1165919282511, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=37.1559633027523, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=31.25, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=34.3612334801762, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.0044052863436, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=33.0396475770925, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=32.15859030837, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=35.1851851851852, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693140, Length=187, Percent_Identity=28.8770053475936, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=134, Percent_Identity=30.5970149253731, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25635; Mature: 25635

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDELKAAEYLHQGLTESGYIVDHAVNGADGLHLAQQQVYDLIILDVNLPELDGW
CEEEEECHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHEEEEEECCCCCCCCH
SVLEQLRRTHSTRVMMLTARGRLADKIRGLDLGADDYLVKPFEFPELLARVRTLMRRSEN
HHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCC
IPVPQVLKVADLELDPGRHRAFRGTQRIDLTTKEFALLHLLMRQSGEVLTRTQIISLVWD
CCHHHHHHHHCCCCCCCCHHHHCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
MNFDCDTNVVEVSIRRLRAKIDDPFDSKLIHTLRGVGYVLEARE
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MRILVVEDELKAAEYLHQGLTESGYIVDHAVNGADGLHLAQQQVYDLIILDVNLPELDGW
CEEEEECHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHEEEEEECCCCCCCCH
SVLEQLRRTHSTRVMMLTARGRLADKIRGLDLGADDYLVKPFEFPELLARVRTLMRRSEN
HHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCC
IPVPQVLKVADLELDPGRHRAFRGTQRIDLTTKEFALLHLLMRQSGEVLTRTQIISLVWD
CCHHHHHHHHCCCCCCCCHHHHCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
MNFDCDTNVVEVSIRRLRAKIDDPFDSKLIHTLRGVGYVLEARE
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]