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The map label for this gene is zwf [H]

Identifier: 77458812

GI number: 77458812

Start: 2964345

End: 2965868

Strand: Direct

Name: zwf [H]

Synonym: Pfl01_2587

Alternate gene names: 77458812

Gene position: 2964345-2965868 (Clockwise)

Preceding gene: 77458811

Following gene: 77458813

Centisome position: 46.04

GC content: 61.02

Gene sequence:

>1524_bases
ATGACCCATACGATCCGCAGAAAATCCAAGGCAGAACCCGCGCCACCGACCACGCTGTTTCTGTTCGGCGCCCACGGTGA
TCTGGTCAAGCGCCTGCTTATGCCGGCGCTGTACAACCTGAGTCGCGACGGCCTGCTGGATGATGGCCTGCGGATCGTCG
GCGTTGACCACAACGCAATCACCGATGAAGCCTTCGCGCAAAAGCTCGAAGACTTCATCCGCACCGAAGTGGCAGCGAAA
GTCGGCAAGGGCGATCAGATGCTTGATCCGGCCTTGTGGGCGAAGCTCGCCAAAGGCATCAGCTACGTCCAGGGTGACTT
CCTGGACGACAGCACTTATTCAGCCCTGGCGGCGAAAATCGCCGACAGCGGCACTGGCAATGCGGTGTTCTACCTGGCCA
CCGCGCCACGTTTCTTCAGCGAAGTGGTGCGCCGTCTCGGCAGCGCCGGATTGCTCGAAGAAACCGCGGAAGCCTTTAGA
AGGGTGGTGATCGAAAAACCGTTCGGCTCCGACCTGCAAACCGCCGAGGCGTTGAACGCCTGCCTGCTCAAGGTCATGTC
GGAAAAGCAGATCTACCGGATCGATCACTATCTGGGCAAGGAAACCGTGCAGAACATTCTGGTCAGCCGGTTCTCCAACA
GCCTGTTCGAAGCGTTCTGGAACAACCACTACATCGACCACGTGCAGATCACCGCCGCCGAAACCGTCGGCGTCGAAACC
CGTGGCAGTTTTTACGAGCACACTGGCGCCCTGCGGGACATGGTGCCCAATCACCTGTTCCAGTTGCTGGCCATGGTCGC
GATGGAACCGCCAGCGGCGTTCGGCGCCGATGCGGTGCGGGGCGAGAAGGCCAAGGTCGTCGGTGCGATCCGGCCCTGGA
CCACCGAGGAAGCACGGGAAAACTCGGTGCGCGGTCAATACAGCGCCGGTGAAGTCGCCGGCAAACCGGTGTCCGGTTAT
CGCGATGAGAACAACGTCTCGCCCGACAGCACCACGGAAACCTACGTGGCGCTGAAAGTGATGATCGACAACTGGCGCTG
GGTCGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGTATGAGCGTGCGCGACACCGAGATCGTCATCTGCTTCAAACCGG
CGCCGTATGCGCAGTTCCGCGATACCGAGGTCGACGAATTGCAGCCGACCTACCTGCGTATCCAGATCCAGCCCAACGAA
GGCATGTGGTTCGACCTGCTGGCCAAGCGGCCGGGGCCGGCGCTGAACATGGCCAATATCGAGCTGGGTTTCGCCTACAA
GGACTTCTTCGAAATGCAGCCGTCCACCGGCTACGAAACCCTGATCTATGACTGCCTGACCGGTGACCAGACGCTGTTCC
AGCGCGCCGACAACATCGAGAACGGCTGGCGCGCGGTACAGCCGTTCCTTGATGCCTGGCAACAGGACGCCAGTGTACAA
ACCTATGCCGCTGGCGAAGACGGGCCGAAAGCCGCCGATGATCTGCTGACTCGCGATGGTCGCGTCTGGCATGGTCTCGG
ATGA

Upstream 100 bases:

>100_bases
TGTTCTCGCGCTACCGCTCCCGCGGCCAGGGCACTTTCGGCGACAAGATTCTTTCGGCCCAGCGCTTCGGCTTCGGCGGC
CATGTGGAGACACCGAAGAA

Downstream 100 bases:

>100_bases
GTGAGCCGATCCGTTTTCTGTTGAGCGACATGGACGGCACGCTGTTGTTGCCCGATCACAGCCTGAGTCAGCGCACTATC
GACGCGGTTCGTTCGCTGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTHTIRRKSKAEPAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLLDDGLRIVGVDHNAITDEAFAQKLEDFIRTEVAAK
VGKGDQMLDPALWAKLAKGISYVQGDFLDDSTYSALAAKIADSGTGNAVFYLATAPRFFSEVVRRLGSAGLLEETAEAFR
RVVIEKPFGSDLQTAEALNACLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNSLFEAFWNNHYIDHVQITAAETVGVET
RGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWTTEEARENSVRGQYSAGEVAGKPVSGY
RDENNVSPDSTTETYVALKVMIDNWRWVGVPFYLRTGKRMSVRDTEIVICFKPAPYAQFRDTEVDELQPTYLRIQIQPNE
GMWFDLLAKRPGPALNMANIELGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWQQDASVQ
TYAAGEDGPKAADDLLTRDGRVWHGLG

Sequences:

>Translated_507_residues
MTHTIRRKSKAEPAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLLDDGLRIVGVDHNAITDEAFAQKLEDFIRTEVAAK
VGKGDQMLDPALWAKLAKGISYVQGDFLDDSTYSALAAKIADSGTGNAVFYLATAPRFFSEVVRRLGSAGLLEETAEAFR
RVVIEKPFGSDLQTAEALNACLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNSLFEAFWNNHYIDHVQITAAETVGVET
RGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWTTEEARENSVRGQYSAGEVAGKPVSGY
RDENNVSPDSTTETYVALKVMIDNWRWVGVPFYLRTGKRMSVRDTEIVICFKPAPYAQFRDTEVDELQPTYLRIQIQPNE
GMWFDLLAKRPGPALNMANIELGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWQQDASVQ
TYAAGEDGPKAADDLLTRDGRVWHGLG
>Mature_506_residues
THTIRRKSKAEPAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLLDDGLRIVGVDHNAITDEAFAQKLEDFIRTEVAAKV
GKGDQMLDPALWAKLAKGISYVQGDFLDDSTYSALAAKIADSGTGNAVFYLATAPRFFSEVVRRLGSAGLLEETAEAFRR
VVIEKPFGSDLQTAEALNACLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNSLFEAFWNNHYIDHVQITAAETVGVETR
GSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWTTEEARENSVRGQYSAGEVAGKPVSGYR
DENNVSPDSTTETYVALKVMIDNWRWVGVPFYLRTGKRMSVRDTEIVICFKPAPYAQFRDTEVDELQPTYLRIQIQPNEG
MWFDLLAKRPGPALNMANIELGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWQQDASVQT
YAAGEDGPKAADDLLTRDGRVWHGLG

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=497, Percent_Identity=34.20523138833, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI108773793, Length=497, Percent_Identity=34.20523138833, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI52145310, Length=371, Percent_Identity=32.8840970350404, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=39.4366197183099, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17538218, Length=506, Percent_Identity=33.9920948616601, Blast_Score=281, Evalue=8e-76,
Organism=Saccharomyces cerevisiae, GI6324088, Length=498, Percent_Identity=32.7309236947791, Blast_Score=267, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24643350, Length=505, Percent_Identity=33.2673267326733, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24643352, Length=505, Percent_Identity=33.2673267326733, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI221513548, Length=504, Percent_Identity=27.7777777777778, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56507; Mature: 56376

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTIRRKSKAEPAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLLDDGLRIVGVDHNAI
CCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
TDEAFAQKLEDFIRTEVAAKVGKGDQMLDPALWAKLAKGISYVQGDFLDDSTYSALAAKI
CHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ADSGTGNAVFYLATAPRFFSEVVRRLGSAGLLEETAEAFRRVVIEKPFGSDLQTAEALNA
HCCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNSLFEAFWNNHYIDHVQITAAETVGVET
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCC
RGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWTTEEARE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCCCCCHHHHH
NSVRGQYSAGEVAGKPVSGYRDENNVSPDSTTETYVALKVMIDNWRWVGVPFYLRTGKRM
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEECCCEEEECEEEEECCCEE
SVRDTEIVICFKPAPYAQFRDTEVDELQPTYLRIQIQPNEGMWFDLLAKRPGPALNMANI
EECCCEEEEEECCCCCCCCCCCCHHHCCCEEEEEEEECCCCCEEEHHHCCCCCCCEEEEE
ELGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWQQDASVQ
EEECCHHHHHHCCCCCCHHHHEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
TYAAGEDGPKAADDLLTRDGRVWHGLG
EEECCCCCCHHHHHHHHCCCCEECCCC
>Mature Secondary Structure 
THTIRRKSKAEPAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLLDDGLRIVGVDHNAI
CCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
TDEAFAQKLEDFIRTEVAAKVGKGDQMLDPALWAKLAKGISYVQGDFLDDSTYSALAAKI
CHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ADSGTGNAVFYLATAPRFFSEVVRRLGSAGLLEETAEAFRRVVIEKPFGSDLQTAEALNA
HCCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNSLFEAFWNNHYIDHVQITAAETVGVET
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCC
RGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWTTEEARE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCCCCCHHHHH
NSVRGQYSAGEVAGKPVSGYRDENNVSPDSTTETYVALKVMIDNWRWVGVPFYLRTGKRM
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEECCCEEEECEEEEECCCEE
SVRDTEIVICFKPAPYAQFRDTEVDELQPTYLRIQIQPNEGMWFDLLAKRPGPALNMANI
EECCCEEEEEECCCCCCCCCCCCHHHCCCEEEEEEEECCCCCEEEHHHCCCCCCCEEEEE
ELGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWQQDASVQ
EEECCHHHHHHCCCCCCHHHHEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
TYAAGEDGPKAADDLLTRDGRVWHGLG
EEECCCCCCHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]