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The map label for this gene is pdxH

Identifier: 77457456

GI number: 77457456

Start: 1402141

End: 1402788

Strand: Direct

Name: pdxH

Synonym: Pfl01_1229

Alternate gene names: 77457456

Gene position: 1402141-1402788 (Clockwise)

Preceding gene: 77457455

Following gene: 77457458

Centisome position: 21.78

GC content: 64.2

Gene sequence:

>648_bases
GTGACCCAGTCTCTGGCAGATATGCGTCGTGATTACACCCGGGATGGCCTGACCGAGGCGCAAGCCCCGGCGGAGCCCTT
TGCGTTGTTTCACCAGTGGTTTGCCGAAGCGGTCAAAACCGAGCAGGCGCCGGTGGAAGCCAACGCCATGACCCTGGCCA
CGGTGGATGCGGACGGCCGGCCGCATTGCCGCATTCTGCTGCTCAAGGGGCTGGACGAGCAGGGCTTCACCTTCTTCACC
AACTACGAAAGTGCCAAGGGCCAGCATCTGGCGGCGAACCCGTTCGCCGCCATGACGTTCTTCTGGCCGACCCTTGAGCG
CCAGGTGCGCATCGAAGGTCGGGTGGTGAAGGTCACACCCGAAGAGTCCGACGCTTATTATCAGGTGCGACCGCTGGGCA
GCCGACTTGGCGCCTGGGCTTCACCGCAGAGCCGGGTGATCAACGGCCGGGGTGAGCTGGAAGATTTGCTCAAGGCGACC
GAGCAACGCTTCACCGACACTCAGCCTCACTGCCCGGAACACTGGGGTGGCTACCGCCTGCTCCCCGAGCGCGTGGAATT
CTGGCAGGGCCGGGCGAGCCGCCTGCACGATCGCCTCAACTACCGTGTGCAGGGCGCCGACTGGATTCTTGAACGTCTGG
CACCCTAA

Upstream 100 bases:

>100_bases
GGCGAAAAAGACTGCACCCGCCAAAGCTGCCGCAACCGACAAGAAAGTCGCTGCGACCGATACCACCAAAAAGTGATCCG
CTAACGAAAAGGAATGCGCC

Downstream 100 bases:

>100_bases
GCAGTCTACCGAGCGGGATAGCCTGCCGCAGCGGCCTCAAGCCACTTCGGCAGGTCCCGGCGCTTGATCTTCTGCGCCTG
AGCCTGCTTCAAACGTTCGA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTQSLADMRRDYTRDGLTEAQAPAEPFALFHQWFAEAVKTEQAPVEANAMTLATVDADGRPHCRILLLKGLDEQGFTFFT
NYESAKGQHLAANPFAAMTFFWPTLERQVRIEGRVVKVTPEESDAYYQVRPLGSRLGAWASPQSRVINGRGELEDLLKAT
EQRFTDTQPHCPEHWGGYRLLPERVEFWQGRASRLHDRLNYRVQGADWILERLAP

Sequences:

>Translated_215_residues
MTQSLADMRRDYTRDGLTEAQAPAEPFALFHQWFAEAVKTEQAPVEANAMTLATVDADGRPHCRILLLKGLDEQGFTFFT
NYESAKGQHLAANPFAAMTFFWPTLERQVRIEGRVVKVTPEESDAYYQVRPLGSRLGAWASPQSRVINGRGELEDLLKAT
EQRFTDTQPHCPEHWGGYRLLPERVEFWQGRASRLHDRLNYRVQGADWILERLAP
>Mature_214_residues
TQSLADMRRDYTRDGLTEAQAPAEPFALFHQWFAEAVKTEQAPVEANAMTLATVDADGRPHCRILLLKGLDEQGFTFFTN
YESAKGQHLAANPFAAMTFFWPTLERQVRIEGRVVKVTPEESDAYYQVRPLGSRLGAWASPQSRVINGRGELEDLLKATE
QRFTDTQPHCPEHWGGYRLLPERVEFWQGRASRLHDRLNYRVQGADWILERLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=229, Percent_Identity=43.2314410480349, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1787926, Length=213, Percent_Identity=41.3145539906103, Blast_Score=177, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17553712, Length=204, Percent_Identity=43.1372549019608, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=44.4976076555024, Blast_Score=176, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45551845, Length=230, Percent_Identity=40, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24644901, Length=230, Percent_Identity=40, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24644903, Length=191, Percent_Identity=27.2251308900524, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_PSEPF (Q3KGY4)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_346961.1
- HSSP:   P65682
- ProteinModelPortal:   Q3KGY4
- SMR:   Q3KGY4
- STRING:   Q3KGY4
- GeneID:   3717078
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1229
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- BioCyc:   PFLU205922:PFL_1229-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24590; Mature: 24459

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 64-64 BINDING 67-67 BINDING 69-69 BINDING 86-86 BINDING 126-126 BINDING 130-130 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSLADMRRDYTRDGLTEAQAPAEPFALFHQWFAEAVKTEQAPVEANAMTLATVDADGR
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCC
PHCRILLLKGLDEQGFTFFTNYESAKGQHLAANPFAAMTFFWPTLERQVRIEGRVVKVTP
CCEEEEEEECCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHCCEEEECCEEEEECC
EESDAYYQVRPLGSRLGAWASPQSRVINGRGELEDLLKATEQRFTDTQPHCPEHWGGYRL
CCCCCEEEEEECHHHHCCCCCCHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LPERVEFWQGRASRLHDRLNYRVQGADWILERLAP
CHHHHHHHCCHHHHHHHHHCEEECCHHHHHHHHCC
>Mature Secondary Structure 
TQSLADMRRDYTRDGLTEAQAPAEPFALFHQWFAEAVKTEQAPVEANAMTLATVDADGR
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCC
PHCRILLLKGLDEQGFTFFTNYESAKGQHLAANPFAAMTFFWPTLERQVRIEGRVVKVTP
CCEEEEEEECCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHCCEEEECCEEEEECC
EESDAYYQVRPLGSRLGAWASPQSRVINGRGELEDLLKATEQRFTDTQPHCPEHWGGYRL
CCCCCEEEEEECHHHHCCCCCCHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LPERVEFWQGRASRLHDRLNYRVQGADWILERLAP
CHHHHHHHCCHHHHHHHHHCEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA