Click here to switch to the map view.

The map label for this gene is ampC [C]

Identifier: 77457454

GI number: 77457454

Start: 1399763

End: 1400908

Strand: Direct

Name: ampC [C]

Synonym: Pfl01_1227

Alternate gene names: 77457454

Gene position: 1399763-1400908 (Clockwise)

Preceding gene: 77457453

Following gene: 77457455

Centisome position: 21.74

GC content: 65.27

Gene sequence:

>1146_bases
GTGCAGATTCAGGGCCATTACGAGCTTCAATTCGAAGCGGTGCGCGAAGCCTTCGCCGCACTGTTCGACGATCCCCAGGA
ACGCGGCGCCGCGTTGTGCATCCGGGTCGGCGGTGAAACCGTCCTCGACCTCTGGTCCGGTACCGCCGACAAGGACGGCG
CCGAAGCCTGGCACAGCGACACCATCGCCAACCTGTTCTCCTGCACCAAGACTTTCACCGCCGTCACCGCGCTGCAACTG
GTCGCCGAAGGCAAGTTGCAGCTCGATGCGCCGGTCGCCCGTTACTGGCCGGAATTCGCCGCTGCCGGCAAGGAGTCCGT
CACCCTGCGCCAACTGCTTTGCCATCAGGCCGGCTTGCCGGCCCTGCGCGAATTGCTGGCGCCGGAAGCGCTGTATGACT
GGCAAACCATGGTCGACGCCCTCGCGGCCGAAGCACCGTGGTGGACGCCGGGCACCGGTCACGGCTATGCCGCGATCACC
TACGGTTGGCTGATCGGCGAATTGCTGCGGCGTGCCGACGGTCGCGGGCCGGGGGAGTCCATTGTGGCACGGGTCGCCAA
ACCGCTGGGGCTGGATTTCCATGTCGGTCTGGCCGACGAAGAATTCCACCGAGTGGCGCACATCGCTCGCGGCAAAGGCA
ACACCGGCGACGCCGCTGCCCAGCGCCTGCTGCAAGTAACCATGCGCGAGCCGACGGCCATGACCACCCGGGCCTTCACC
AATCCGCCGTCGGTGCTCACCAGCACCAACAAACCGGAATGGCGACGCATGCAGCAACCGGCGGCCAACGGCCACGGCAA
TGCCCGCAGTCTGGCCGGGTTCTACGCCGGTCTGCTCGACGGCAGCCTGCTGGAAAGCGAAATGCTCGACGAACTGACCC
GTGAACACAGCCTCGGCGAGGACAAGACCTTGCTGACCCGCACCCGTTTCGGTCTCGGTTGCATGCTCGATCAACCCGAC
GTGCCGAACGCCACTTACGGCCTCGGCCCGCGTGCATTCGGCCATCCGGGTGCTGGCGGTTCCATCGGTTTTGCTGATCC
GGAGCACGATGTGGCCTTCGGATTTGTGACAAATACCCTGGGGCCGTACGTCTTGATGGATCCGCGCGCGCAGAAGCTGG
CGCGGGTACTTGCCACTTGTCTGTAA

Upstream 100 bases:

>100_bases
CAAAACCTGAAGACCGCCCGGCCCGCAGCGGTTCCCAAAACCCTCTCGGGCTGGAACAATGCGGGCCACTTTGTAGAGCG
TTTTCGCGGGGGAGTTGCGG

Downstream 100 bases:

>100_bases
AGCGTCGTCCGAGGTTCCAGGGCCGGAACCTCATGGCGATTTTCGTTTCAAAGCGTCTGTTTATCCGGGCGAAAGTCCTC
TGATTGTTCACTAATTCTTT

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Esterase/Lipase LipP; Beta-Lactamase Class C; Esterase A; Beta-Lactamase Family Protein; Esterase/Lipase/Beta-Lactamase; Lactone Hydrolase; Beta-Lactamase Protein; Esterase LipL; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Secreted Peptidase; Beta Lactamase; Fusion Of Enoyl-CoA Hydratase; Beta-Lactamase-Like Protein; Lipase LipE; Hydrolase; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; Beta-Lactamase Family

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MQIQGHYELQFEAVREAFAALFDDPQERGAALCIRVGGETVLDLWSGTADKDGAEAWHSDTIANLFSCTKTFTAVTALQL
VAEGKLQLDAPVARYWPEFAAAGKESVTLRQLLCHQAGLPALRELLAPEALYDWQTMVDALAAEAPWWTPGTGHGYAAIT
YGWLIGELLRRADGRGPGESIVARVAKPLGLDFHVGLADEEFHRVAHIARGKGNTGDAAAQRLLQVTMREPTAMTTRAFT
NPPSVLTSTNKPEWRRMQQPAANGHGNARSLAGFYAGLLDGSLLESEMLDELTREHSLGEDKTLLTRTRFGLGCMLDQPD
VPNATYGLGPRAFGHPGAGGSIGFADPEHDVAFGFVTNTLGPYVLMDPRAQKLARVLATCL

Sequences:

>Translated_381_residues
MQIQGHYELQFEAVREAFAALFDDPQERGAALCIRVGGETVLDLWSGTADKDGAEAWHSDTIANLFSCTKTFTAVTALQL
VAEGKLQLDAPVARYWPEFAAAGKESVTLRQLLCHQAGLPALRELLAPEALYDWQTMVDALAAEAPWWTPGTGHGYAAIT
YGWLIGELLRRADGRGPGESIVARVAKPLGLDFHVGLADEEFHRVAHIARGKGNTGDAAAQRLLQVTMREPTAMTTRAFT
NPPSVLTSTNKPEWRRMQQPAANGHGNARSLAGFYAGLLDGSLLESEMLDELTREHSLGEDKTLLTRTRFGLGCMLDQPD
VPNATYGLGPRAFGHPGAGGSIGFADPEHDVAFGFVTNTLGPYVLMDPRAQKLARVLATCL
>Mature_381_residues
MQIQGHYELQFEAVREAFAALFDDPQERGAALCIRVGGETVLDLWSGTADKDGAEAWHSDTIANLFSCTKTFTAVTALQL
VAEGKLQLDAPVARYWPEFAAAGKESVTLRQLLCHQAGLPALRELLAPEALYDWQTMVDALAAEAPWWTPGTGHGYAAIT
YGWLIGELLRRADGRGPGESIVARVAKPLGLDFHVGLADEEFHRVAHIARGKGNTGDAAAQRLLQVTMREPTAMTTRAFT
NPPSVLTSTNKPEWRRMQQPAANGHGNARSLAGFYAGLLDGSLLESEMLDELTREHSLGEDKTLLTRTRFGLGCMLDQPD
VPNATYGLGPRAFGHPGAGGSIGFADPEHDVAFGFVTNTLGPYVLMDPRAQKLARVLATCL

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=211, Percent_Identity=27.0142180094787, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17535191, Length=372, Percent_Identity=31.989247311828, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17538001, Length=378, Percent_Identity=32.010582010582, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71983659, Length=363, Percent_Identity=32.2314049586777, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17535177, Length=375, Percent_Identity=28, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538474, Length=376, Percent_Identity=28.4574468085106, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71983666, Length=292, Percent_Identity=33.5616438356164, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71990590, Length=380, Percent_Identity=23.1578947368421, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 41178; Mature: 41178

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIQGHYELQFEAVREAFAALFDDPQERGAALCIRVGGETVLDLWSGTADKDGAEAWHSD
CCCCCCHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHH
TIANLFSCTKTFTAVTALQLVAEGKLQLDAPVARYWPEFAAAGKESVTLRQLLCHQAGLP
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHCHHHHHCCCCHHHHHHHHHHHCCCH
ALRELLAPEALYDWQTMVDALAAEAPWWTPGTGHGYAAITYGWLIGELLRRADGRGPGES
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
IVARVAKPLGLDFHVGLADEEFHRVAHIARGKGNTGDAAAQRLLQVTMREPTAMTTRAFT
HHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
NPPSVLTSTNKPEWRRMQQPAANGHGNARSLAGFYAGLLDGSLLESEMLDELTREHSLGE
CCCCHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
DKTLLTRTRFGLGCMLDQPDVPNATYGLGPRAFGHPGAGGSIGFADPEHDVAFGFVTNTL
CCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHCC
GPYVLMDPRAQKLARVLATCL
CCEEEECCHHHHHHHHHHHHC
>Mature Secondary Structure
MQIQGHYELQFEAVREAFAALFDDPQERGAALCIRVGGETVLDLWSGTADKDGAEAWHSD
CCCCCCHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHH
TIANLFSCTKTFTAVTALQLVAEGKLQLDAPVARYWPEFAAAGKESVTLRQLLCHQAGLP
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHCHHHHHCCCCHHHHHHHHHHHCCCH
ALRELLAPEALYDWQTMVDALAAEAPWWTPGTGHGYAAITYGWLIGELLRRADGRGPGES
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
IVARVAKPLGLDFHVGLADEEFHRVAHIARGKGNTGDAAAQRLLQVTMREPTAMTTRAFT
HHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
NPPSVLTSTNKPEWRRMQQPAANGHGNARSLAGFYAGLLDGSLLESEMLDELTREHSLGE
CCCCHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
DKTLLTRTRFGLGCMLDQPDVPNATYGLGPRAFGHPGAGGSIGFADPEHDVAFGFVTNTL
CCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHCC
GPYVLMDPRAQKLARVLATCL
CCEEEECCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA