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The map label for this gene is yeiG [H]

Identifier: 77457353

GI number: 77457353

Start: 1303387

End: 1304232

Strand: Direct

Name: yeiG [H]

Synonym: Pfl01_1126

Alternate gene names: 77457353

Gene position: 1303387-1304232 (Clockwise)

Preceding gene: 77457352

Following gene: 77457354

Centisome position: 20.24

GC content: 59.69

Gene sequence:

>846_bases
ATGAGTCTGGAAAACATCTCCTGTCAGAAAAGTTTCGGCGGATGGCACAAGCGCTATCGCCATCGTTCCGAAGTACTGGG
TTGCGACATGGTGTTCGCCGTGTACCTGCCGCCGCAGGCAGAGCAGGGCGGCAAGTTGCCGGTGCTGTACTGGTTGTCGG
GCCTGACCTGCACGGACGAGAACTTCATGCAGAAGGCCGGTGCCATGCGCATGGCGGCTGAATTGGGGCTGATTATCGTG
GCCCCGGACACCAGCCCACGCGGCCCGGATGTACCGGGCGATCCGGATGGTGCGTGGGATTTCGGCCTCGGTGCCGGCTT
CTATCTGAATGCCACGCAGGAACCTTGGTCGCGGCACTATCGGATGCATGACTATGTCGTGCAGGAATTGCCTTCACTGG
TTGAAGCGCATTTCCCGGCGTCGGACAAACGCAGCATCAGCGGCCACTCGATGGGCGGTCACGGTGCATTGGTCTGTGCC
TTGCGCAATCCAGGGCGTTATCAGTCAGTATCAGCGTTCTCTCCGATCAATAATCCGATGGATTGCCCGTGGGGCCAGAA
AGCGTTCTCCCGCTATCTGGGCGAAGACCGTTCGAAATGGCGCGAGTGGGATGCCTGTGCGCTGATCGCCGAGACGGACG
AAAAGCTGCCATTGCTGGTCGATCAGGGTGATCGCGACGACTTCCTCGCCACCCAGCTCAAACCCGAGGCCCTGCAACAA
GCGGCAAAACAGGCGGGGCATCCGCTGACGTTGCGCCTGCAACCGGGCTACGATCACAGCTATTTCTTCATCGCCAGCTT
CATTGACGACCACTTGCAGCATCACGCGCGCGCTCTGAAGAGTTAA

Upstream 100 bases:

>100_bases
CTGATGCACGAAGGCAAGAGCATCCGTACCGTCATTCATTTCTGATCAATCACGATGCCACGACTGCCGGTGTGCAGCCG
TGGCTGCGTAGGAGTCCTAC

Downstream 100 bases:

>100_bases
TGCAGGTAGAATCACGCCCTGACAAAATTCGGGGCGTTTTTTTATGCGTATTGGCCACGGCTATGATGTGCACCGTTTCG
CTGAAGGCGATTTCATTACT

Product: putative esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSLENISCQKSFGGWHKRYRHRSEVLGCDMVFAVYLPPQAEQGGKLPVLYWLSGLTCTDENFMQKAGAMRMAAELGLIIV
APDTSPRGPDVPGDPDGAWDFGLGAGFYLNATQEPWSRHYRMHDYVVQELPSLVEAHFPASDKRSISGHSMGGHGALVCA
LRNPGRYQSVSAFSPINNPMDCPWGQKAFSRYLGEDRSKWREWDACALIAETDEKLPLLVDQGDRDDFLATQLKPEALQQ
AAKQAGHPLTLRLQPGYDHSYFFIASFIDDHLQHHARALKS

Sequences:

>Translated_281_residues
MSLENISCQKSFGGWHKRYRHRSEVLGCDMVFAVYLPPQAEQGGKLPVLYWLSGLTCTDENFMQKAGAMRMAAELGLIIV
APDTSPRGPDVPGDPDGAWDFGLGAGFYLNATQEPWSRHYRMHDYVVQELPSLVEAHFPASDKRSISGHSMGGHGALVCA
LRNPGRYQSVSAFSPINNPMDCPWGQKAFSRYLGEDRSKWREWDACALIAETDEKLPLLVDQGDRDDFLATQLKPEALQQ
AAKQAGHPLTLRLQPGYDHSYFFIASFIDDHLQHHARALKS
>Mature_280_residues
SLENISCQKSFGGWHKRYRHRSEVLGCDMVFAVYLPPQAEQGGKLPVLYWLSGLTCTDENFMQKAGAMRMAAELGLIIVA
PDTSPRGPDVPGDPDGAWDFGLGAGFYLNATQEPWSRHYRMHDYVVQELPSLVEAHFPASDKRSISGHSMGGHGALVCAL
RNPGRYQSVSAFSPINNPMDCPWGQKAFSRYLGEDRSKWREWDACALIAETDEKLPLLVDQGDRDDFLATQLKPEALQQA
AKQAGHPLTLRLQPGYDHSYFFIASFIDDHLQHHARALKS

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=284, Percent_Identity=55.9859154929578, Blast_Score=332, Evalue=2e-91,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=59.4982078853047, Blast_Score=342, Evalue=1e-95,
Organism=Escherichia coli, GI1786551, Length=278, Percent_Identity=53.9568345323741, Blast_Score=310, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=49.6478873239437, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322393, Length=288, Percent_Identity=42.7083333333333, Blast_Score=235, Evalue=5e-63,
Organism=Drosophila melanogaster, GI45551932, Length=286, Percent_Identity=54.5454545454545, Blast_Score=311, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24648347, Length=286, Percent_Identity=54.5454545454545, Blast_Score=310, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31376; Mature: 31245

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLENISCQKSFGGWHKRYRHRSEVLGCDMVFAVYLPPQAEQGGKLPVLYWLSGLTCTDE
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCCH
NFMQKAGAMRMAAELGLIIVAPDTSPRGPDVPGDPDGAWDFGLGAGFYLNATQEPWSRHY
HHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHHHH
RMHDYVVQELPSLVEAHFPASDKRSISGHSMGGHGALVCALRNPGRYQSVSAFSPINNPM
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
DCPWGQKAFSRYLGEDRSKWREWDACALIAETDEKLPLLVDQGDRDDFLATQLKPEALQQ
CCCCCHHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHCCCHHHHHH
AAKQAGHPLTLRLQPGYDHSYFFIASFIDDHLQHHARALKS
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLENISCQKSFGGWHKRYRHRSEVLGCDMVFAVYLPPQAEQGGKLPVLYWLSGLTCTDE
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCCH
NFMQKAGAMRMAAELGLIIVAPDTSPRGPDVPGDPDGAWDFGLGAGFYLNATQEPWSRHY
HHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHHHH
RMHDYVVQELPSLVEAHFPASDKRSISGHSMGGHGALVCALRNPGRYQSVSAFSPINNPM
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
DCPWGQKAFSRYLGEDRSKWREWDACALIAETDEKLPLLVDQGDRDDFLATQLKPEALQQ
CCCCCHHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHCCCHHHHHH
AAKQAGHPLTLRLQPGYDHSYFFIASFIDDHLQHHARALKS
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA