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The map label for this gene is frmA [H]

Identifier: 77457352

GI number: 77457352

Start: 1302219

End: 1303331

Strand: Direct

Name: frmA [H]

Synonym: Pfl01_1125

Alternate gene names: 77457352

Gene position: 1302219-1303331 (Clockwise)

Preceding gene: 77457350

Following gene: 77457353

Centisome position: 20.23

GC content: 60.2

Gene sequence:

>1113_bases
ATGATCAAGTCGCGCGCCGCCGTTGCCTTCGAGGCCAAAAAGCCGCTGGAAATCGTAGAAGTCGATGTCGCCATGCCCAA
GGCCGGTGAAGTATTGCTGCGCGTGGTGGCTTCCGGGGTTTGCCACACTGACGCTTACACCCTGTCCGGCGCGGACCCGG
AAGGTATCTTCCCGTCGATCCTCGGCCACGAAGGCGGCGCTATCGTCGAAGCGATCGGCGAAGGCGTGACATCCGTGGCC
GTCGGTGATCACGTGATTCCGCTTTACACCCCGGAATGCGGTCAGTGCAAATTCTGTAAGTCGGGCAAGACCAACCTGTG
TCAGGCGATTCGCGCCACCCAGGGCAAGGGCCTGATGCCGGACGGCACTTCGCGCTTTTCCTACAAGGGCCAAACGATTT
TCCACTACATGGGTACTTCGACGTTCTCCGAGTACACCGTGCTGCCGGAAATCTCCGTGGCCAAGATCTCCAAGGATGCG
CCGCTGGAAAAGGTCTGCCTGCTCGGTTGCGGCGTGACCACCGGTATCGGTGCGGTGATCAACACCGCCAAGGTCAAACC
GGGTGACACCGTGGCCATCTTCGGTCTCGGCGGCATCGGACTGTCGGCCGTGATCGGCGCGGTGAAGGCCAAGGCCTCAC
GGATCATCGCCATCGACATCAACCCGGCCAAGTTCGAAATCGCCAAACAATTGGGTGCCACCGACTGCGTGAACCCGAAA
GACTTCGATCGTCCGATCCAGGAAGTGATCGTCGACATGACCGATGGCGGCGTCGACTTCTCCTTCGAATGCATCGGCAA
CGTGCAACTTATGCGCGCAGCCCTCGAGTGCTGCCATAAAGGCTGGGGCGAGTCGGTGATCATCGGTGTGGCCGGTGCCG
GCCAGGAAATCTCCACCCGTCCGTTCCAGCTGGTGACCGGTCGCGTCTGGCGCGGTTCCGCATTCGGCGGCGTGCGTGGT
CGTACCGAATTGCCAAGCTACGTCGACATGGCGCAAAGCGGCGAAATCCCGCTGGATACTTTCATCACTCACACCATGGG
CCTGGAAGACATCAACAAGGCCTTCGACCTGATGCACGAAGGCAAGAGCATCCGTACCGTCATTCATTTCTGA

Upstream 100 bases:

>100_bases
TGGCAATAATGTTTTGCTTTTGCCCGGATTATTCATCAAGCGGCGCTGAACTACACTGACCGTCTGGTTTTTTATTCAAT
GGATTCACTGGAGAGTCAGC

Downstream 100 bases:

>100_bases
TCAATCACGATGCCACGACTGCCGGTGTGCAGCCGTGGCTGCGTAGGAGTCCTACATGAGTCTGGAAAACATCTCCTGTC
AGAAAAGTTTCGGCGGATGG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSILGHEGGAIVEAIGEGVTSVA
VGDHVIPLYTPECGQCKFCKSGKTNLCQAIRATQGKGLMPDGTSRFSYKGQTIFHYMGTSTFSEYTVLPEISVAKISKDA
PLEKVCLLGCGVTTGIGAVINTAKVKPGDTVAIFGLGGIGLSAVIGAVKAKASRIIAIDINPAKFEIAKQLGATDCVNPK
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRG
RTELPSYVDMAQSGEIPLDTFITHTMGLEDINKAFDLMHEGKSIRTVIHF

Sequences:

>Translated_370_residues
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSILGHEGGAIVEAIGEGVTSVA
VGDHVIPLYTPECGQCKFCKSGKTNLCQAIRATQGKGLMPDGTSRFSYKGQTIFHYMGTSTFSEYTVLPEISVAKISKDA
PLEKVCLLGCGVTTGIGAVINTAKVKPGDTVAIFGLGGIGLSAVIGAVKAKASRIIAIDINPAKFEIAKQLGATDCVNPK
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRG
RTELPSYVDMAQSGEIPLDTFITHTMGLEDINKAFDLMHEGKSIRTVIHF
>Mature_370_residues
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSILGHEGGAIVEAIGEGVTSVA
VGDHVIPLYTPECGQCKFCKSGKTNLCQAIRATQGKGLMPDGTSRFSYKGQTIFHYMGTSTFSEYTVLPEISVAKISKDA
PLEKVCLLGCGVTTGIGAVINTAKVKPGDTVAIFGLGGIGLSAVIGAVKAKASRIIAIDINPAKFEIAKQLGATDCVNPK
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRG
RTELPSYVDMAQSGEIPLDTFITHTMGLEDINKAFDLMHEGKSIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=65.7608695652174, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=53.2432432432432, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=51.8918918918919, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=51.6216216216216, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=52.5333333333333, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=48.9130434782609, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=49.171270718232, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=47.7088948787062, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=47.7088948787062, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=70.4607046070461, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=24.7368421052632, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787863, Length=360, Percent_Identity=25, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=26.3013698630137, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=25.7879656160458, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=349, Percent_Identity=29.2263610315186, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1786825, Length=256, Percent_Identity=26.953125, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI226510992, Length=374, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788075, Length=368, Percent_Identity=25, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786518, Length=250, Percent_Identity=28, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=56.951871657754, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=56.6489361702128, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=56.268221574344, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562584, Length=375, Percent_Identity=29.6, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=376, Percent_Identity=26.8617021276596, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=375, Percent_Identity=27.7333333333333, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=24.6537396121884, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=363, Percent_Identity=24.5179063360882, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=59.8382749326146, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319621, Length=367, Percent_Identity=29.1553133514986, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=388, Percent_Identity=28.8659793814433, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=368, Percent_Identity=28.804347826087, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=28.4403669724771, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=27.217125382263, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=365, Percent_Identity=27.3972602739726, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=365, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=266, Percent_Identity=25.9398496240602, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=63.1720430107527, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=27.0114942528736, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17737897, Length=357, Percent_Identity=24.9299719887955, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39083; Mature: 39083

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSI
CCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHH
LGHEGGAIVEAIGEGVTSVAVGDHVIPLYTPECGQCKFCKSGKTNLCQAIRATQGKGLMP
HCCCCCHHHHHHHCCHHEEEECCEEEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCCCC
DGTSRFSYKGQTIFHYMGTSTFSEYTVLPEISVAKISKDAPLEKVCLLGCGVTTGIGAVI
CCCCCEEECCCEEEEEECCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHHHH
NTAKVKPGDTVAIFGLGGIGLSAVIGAVKAKASRIIAIDINPAKFEIAKQLGATDCVNPK
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCH
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTR
HHHHHHHHHHEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PFQLVTGRVWRGSAFGGVRGRTELPSYVDMAQSGEIPLDTFITHTMGLEDINKAFDLMHE
CEEEEECEEECCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHC
GKSIRTVIHF
CCCEEEEECC
>Mature Secondary Structure
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSI
CCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHH
LGHEGGAIVEAIGEGVTSVAVGDHVIPLYTPECGQCKFCKSGKTNLCQAIRATQGKGLMP
HCCCCCHHHHHHHCCHHEEEECCEEEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCCCC
DGTSRFSYKGQTIFHYMGTSTFSEYTVLPEISVAKISKDAPLEKVCLLGCGVTTGIGAVI
CCCCCEEECCCEEEEEECCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHHHH
NTAKVKPGDTVAIFGLGGIGLSAVIGAVKAKASRIIAIDINPAKFEIAKQLGATDCVNPK
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCH
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTR
HHHHHHHHHHEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PFQLVTGRVWRGSAFGGVRGRTELPSYVDMAQSGEIPLDTFITHTMGLEDINKAFDLMHE
CEEEEECEEECCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHC
GKSIRTVIHF
CCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]