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The map label for this gene is lpxB

Identifier: 77457341

GI number: 77457341

Start: 1287924

End: 1289054

Strand: Direct

Name: lpxB

Synonym: Pfl01_1114

Alternate gene names: 77457341

Gene position: 1287924-1289054 (Clockwise)

Preceding gene: 77457340

Following gene: 77457342

Centisome position: 20.0

GC content: 62.95

Gene sequence:

>1131_bases
ATGGCCAATCTGCGTATTGCGCTGGTGGCGGGTGAGGCTTCCGGTGACATTCTGGGCGCCGGTCTCATGCGCGCCCTCAA
GGCACAGCACCCTGCGGTGGAGTTCATCGGTGTCGGCGGTCCGCTGATGCAGGCCGAAGGCCTGACCTCCTATTTTCCGA
TGGAACGTCTGTCGGTCATGGGGCTGGTGGAAGTCCTGGGGCGGTTGCGTGAACTGCTCAAGCGCCGCAAGGACCTCATC
GCCACGCTTATCGCTGAAAAACCGGATGTATTCATCGGTATCGACGCACCGGACTTCAACCTCAATATCGAACTCAAGCT
GCGTCAGGCCGGAATCAAGACCGTGCACTACGTCAGCCCTTCGGTATGGGCGTGGCGGCAGAAGCGGGTGCTGAAGATCC
GCGAAGGCTGCGACCTGATGCTCACGCTGCTGCCGTTCGAAGCCAGATTCTATGAAGAGAAAGGCGTCCCGGTGCGGTTC
GTCGGCCATACGCTGGCCGACACCATTCCGCTGGAGGCCGATCGCGCCGCTGCGCGTGCCGAACTCGGTCTGCCGGACGG
TCCGCTGGTGGCATTGATGCCCGGCAGTCGGGGTGGCGAAGTCAGTCGTCTGGGGGCGCTGTTCCTTGATACCGCCCAAC
GTCTGCGTGCCATGCGCCCGGGTGTGCGTTTCGTCATCCCTTGCGCCAATCCCGAGCGTCGTGCCCAGCTCGAAGAGCTG
TTGGCTGGCCGCGACCTGCCGGTGACTCTGCTCGATGGCAAATCCCACCTGGCTCTGGCAGCGTGCAACGCGGTTCTCAT
CGCGTCGGGCACGGCAACCCTGGAAGCGCTGCTGTACAAGCGTCCGATGGTCGTGGCCTACCGTCTTGCGCCGCTGACGT
TCTGGATTCTCAAGCGCATGGTCAAGAGCCCGTACGTGTCCCTGCCGAACCTGCTGGCCCAGCGATTGCTGGTCCCGGAA
TTGTTGCAGGATGATGCGACTGTCGAGGCGCTTGCCCAGACCCTGTCGCCGTTGATCGACGGTGGCGAAGAGCAGACCCG
CGGCTTCGACGAGATCCATCGCACCCTGCGCCTGGACGCTTCCAATCAGGCGGCTGATGCCGTTCTCAACCTGATCGGGC
AAACACGATGA

Upstream 100 bases:

>100_bases
AGGCGCTGGCCGAGCTGGCCGAGCCGTCTGCACAGTTCCCGGAAGTCGCGATGTTCCGTGACTCCATCCAGTCGTCGACC
CGCGGCATCACCCGCTGACC

Downstream 100 bases:

>100_bases
GCAAGACAAGCATGCAGATGGGGCTGGATTTTACCCTGGTCGCCGAAGTCGAAGAACTGGTGGCCGGTGTCGATGAAGTC
GGTCGTGGCCCGCTGTGCGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MANLRIALVAGEASGDILGAGLMRALKAQHPAVEFIGVGGPLMQAEGLTSYFPMERLSVMGLVEVLGRLRELLKRRKDLI
ATLIAEKPDVFIGIDAPDFNLNIELKLRQAGIKTVHYVSPSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEKGVPVRF
VGHTLADTIPLEADRAAARAELGLPDGPLVALMPGSRGGEVSRLGALFLDTAQRLRAMRPGVRFVIPCANPERRAQLEEL
LAGRDLPVTLLDGKSHLALAACNAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRMVKSPYVSLPNLLAQRLLVPE
LLQDDATVEALAQTLSPLIDGGEEQTRGFDEIHRTLRLDASNQAADAVLNLIGQTR

Sequences:

>Translated_376_residues
MANLRIALVAGEASGDILGAGLMRALKAQHPAVEFIGVGGPLMQAEGLTSYFPMERLSVMGLVEVLGRLRELLKRRKDLI
ATLIAEKPDVFIGIDAPDFNLNIELKLRQAGIKTVHYVSPSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEKGVPVRF
VGHTLADTIPLEADRAAARAELGLPDGPLVALMPGSRGGEVSRLGALFLDTAQRLRAMRPGVRFVIPCANPERRAQLEEL
LAGRDLPVTLLDGKSHLALAACNAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRMVKSPYVSLPNLLAQRLLVPE
LLQDDATVEALAQTLSPLIDGGEEQTRGFDEIHRTLRLDASNQAADAVLNLIGQTR
>Mature_375_residues
ANLRIALVAGEASGDILGAGLMRALKAQHPAVEFIGVGGPLMQAEGLTSYFPMERLSVMGLVEVLGRLRELLKRRKDLIA
TLIAEKPDVFIGIDAPDFNLNIELKLRQAGIKTVHYVSPSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEKGVPVRFV
GHTLADTIPLEADRAAARAELGLPDGPLVALMPGSRGGEVSRLGALFLDTAQRLRAMRPGVRFVIPCANPERRAQLEELL
AGRDLPVTLLDGKSHLALAACNAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRMVKSPYVSLPNLLAQRLLVPEL
LQDDATVEALAQTLSPLIDGGEEQTRGFDEIHRTLRLDASNQAADAVLNLIGQTR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=56.1497326203209, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_PSEPF (Q3KH99)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_346846.1
- ProteinModelPortal:   Q3KH99
- STRING:   Q3KH99
- GeneID:   3716538
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_1114
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   PFLU205922:PFL_1114-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41123; Mature: 40992

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLRIALVAGEASGDILGAGLMRALKAQHPAVEFIGVGGPLMQAEGLTSYFPMERLSVM
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCHHCCHHHHHHH
GLVEVLGRLRELLKRRKDLIATLIAEKPDVFIGIDAPDFNLNIELKLRQAGIKTVHYVSP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCEEEECCC
SVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEKGVPVRFVGHTLADTIPLEADRAAARA
CHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCEEEEECHHHHHCCCCCCHHHHHHH
ELGLPDGPLVALMPGSRGGEVSRLGALFLDTAQRLRAMRPGVRFVIPCANPERRAQLEEL
HCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LAGRDLPVTLLDGKSHLALAACNAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRM
HCCCCCCEEEECCCCCEEHHHHCEEEEECCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHH
VKSPYVSLPNLLAQRLLVPELLQDDATVEALAQTLSPLIDGGEEQTRGFDEIHRTLRLDA
HHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHCCCC
SNQAADAVLNLIGQTR
CCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ANLRIALVAGEASGDILGAGLMRALKAQHPAVEFIGVGGPLMQAEGLTSYFPMERLSVM
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCHHCCHHHHHHH
GLVEVLGRLRELLKRRKDLIATLIAEKPDVFIGIDAPDFNLNIELKLRQAGIKTVHYVSP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCEEEECCC
SVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEKGVPVRFVGHTLADTIPLEADRAAARA
CHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCEEEEECHHHHHCCCCCCHHHHHHH
ELGLPDGPLVALMPGSRGGEVSRLGALFLDTAQRLRAMRPGVRFVIPCANPERRAQLEEL
HCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LAGRDLPVTLLDGKSHLALAACNAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRM
HCCCCCCEEEECCCCCEEHHHHCEEEEECCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHH
VKSPYVSLPNLLAQRLLVPELLQDDATVEALAQTLSPLIDGGEEQTRGFDEIHRTLRLDA
HHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHCCCC
SNQAADAVLNLIGQTR
CCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA