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The map label for this gene is hemE [H]

Identifier: 77456643

GI number: 77456643

Start: 476414

End: 477481

Strand: Direct

Name: hemE [H]

Synonym: Pfl01_0415

Alternate gene names: 77456643

Gene position: 476414-477481 (Clockwise)

Preceding gene: 77456642

Following gene: 77456645

Centisome position: 7.4

GC content: 63.01

Gene sequence:

>1068_bases
ATGACTGCCCTGAAGAACGACCGTTTCCTCCGCGCCCTGCTCAAGCAACCCGTAGACGTCACCCCAGTGTGGATGATGCG
CCAGGCCGGCCGCTACCTGCCGGAATACCGCGCCAGCCGCGCCCAGGCCGGTGATTTCATGAGCCTGTGCATGAATCCGG
AATTCGCCTGCGAAGTCACGCTGCAACCGCTGGACCGCTATCCGCAACTGGACGCGGCGATCCTGTTCTCCGACATCCTC
ACCATTCCCGATGCCATGGGCCAGGGCCTGTACTTCGAGACCGGTGAAGGTCCGCGCTTCAAGAAAGTCGTCAGCACCCT
GGCCGACATCGAAGCCCTGCCGATCCCGGATCCGCACAAAGACCTCGGTTACGTGATGGACGCCGTCAGCACCATCCGCC
GCGAACTGAATGGCCGTGTACCGCTGATCGGTTTCTCCGGCAGCCCTTGGACTCTCGCCACGTACATGGTCGAAGGCGGT
TCGTCGAAAGACTTCCGCAAGACCAAGGCGATGCTCTACGACAACCCACAAGCCATGCACCTGCTGCTGGACAAACTGGC
GCAGTCGGTGACTTCGTACCTGAACGGCCAGATCCAGGCCGGTGCGCAAGCGGTGCAGATCTTCGATACCTGGGGCGGCA
ACCTGTCGGCGGCGGCATATCAGGAATTCTCACTGGCCTACATGAAGAAAATCGTCAGCGGCCTGATCCGCGAGCACGAC
GGTCGCAAGGTGCCGGTGATCCTGTTCACCAAGAACGGCGGCCTGTGGCTGGAAAGCATCGCCGAGGCTGGTGCCGACGC
ACTGGGCCTGGACTGGACCTGCGACATTGGCAACGCCCGCGCTCGCGTTGGCGACAAGGTGGCACTGCAAGGCAACATGG
ACCCGACCGTGCTCTACGCCAAGCCGGAAGCGATCCGCACCGAAGTCGGGCGCATCCTCGCCAGCTACGGCAAAGGCAGC
GGCCACGTGTTCAACCTCGGCCACGGCATCACGCCGGAAGTCGATCCGGAACACGCTGGCGCGTTCCTGCGCGCGGTGCA
CGAGTTGTCGGCGCAGTATCACGAGTGA

Upstream 100 bases:

>100_bases
AACGCGACAAATTGACCCGATAGACAAAAGGCTGACCTGCATCCGTGCCTTTTGCGTCGCGCTCTGAGAAAATGCCCGCA
CTTTTTTTCCGGATGCCGAC

Downstream 100 bases:

>100_bases
TCGGCGCTCAGCTCTGATGGTAGAAAAAACGCCCGGATTATGCCGGGCGTTTTTTGTGGGCGTGAATCAGGCTTTGACGC
CACCGAGCGGCGGCAGCTTC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAQAGDFMSLCMNPEFACEVTLQPLDRYPQLDAAILFSDIL
TIPDAMGQGLYFETGEGPRFKKVVSTLADIEALPIPDPHKDLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGG
SSKDFRKTKAMLYDNPQAMHLLLDKLAQSVTSYLNGQIQAGAQAVQIFDTWGGNLSAAAYQEFSLAYMKKIVSGLIREHD
GRKVPVILFTKNGGLWLESIAEAGADALGLDWTCDIGNARARVGDKVALQGNMDPTVLYAKPEAIRTEVGRILASYGKGS
GHVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE

Sequences:

>Translated_355_residues
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAQAGDFMSLCMNPEFACEVTLQPLDRYPQLDAAILFSDIL
TIPDAMGQGLYFETGEGPRFKKVVSTLADIEALPIPDPHKDLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGG
SSKDFRKTKAMLYDNPQAMHLLLDKLAQSVTSYLNGQIQAGAQAVQIFDTWGGNLSAAAYQEFSLAYMKKIVSGLIREHD
GRKVPVILFTKNGGLWLESIAEAGADALGLDWTCDIGNARARVGDKVALQGNMDPTVLYAKPEAIRTEVGRILASYGKGS
GHVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE
>Mature_354_residues
TALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAQAGDFMSLCMNPEFACEVTLQPLDRYPQLDAAILFSDILT
IPDAMGQGLYFETGEGPRFKKVVSTLADIEALPIPDPHKDLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGGS
SKDFRKTKAMLYDNPQAMHLLLDKLAQSVTSYLNGQIQAGAQAVQIFDTWGGNLSAAAYQEFSLAYMKKIVSGLIREHDG
RKVPVILFTKNGGLWLESIAEAGADALGLDWTCDIGNARARVGDKVALQGNMDPTVLYAKPEAIRTEVGRILASYGKGSG
HVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=49.2877492877493, Blast_Score=326, Evalue=2e-89,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=74.5762711864407, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6320252, Length=358, Percent_Identity=38.8268156424581, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI221330099, Length=349, Percent_Identity=42.4068767908309, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI19921920, Length=349, Percent_Identity=42.4068767908309, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38965; Mature: 38834

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAQAGDFMSLCMNPEFACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCCEEEEE
LQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFKKVVSTLADIEALPIPDPHK
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCH
DLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKTKAMLYDNPQAMH
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHH
LLLDKLAQSVTSYLNGQIQAGAQAVQIFDTWGGNLSAAAYQEFSLAYMKKIVSGLIREHD
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRKVPVILFTKNGGLWLESIAEAGADALGLDWTCDIGNARARVGDKVALQGNMDPTVLYA
CCEEEEEEEECCCCHHHHHHHHCCCCEECCEEEECCCCCHHHCCCEEEEECCCCCEEEEE
KPEAIRTEVGRILASYGKGSGHVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE
CCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAQAGDFMSLCMNPEFACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCCEEEEE
LQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFKKVVSTLADIEALPIPDPHK
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCH
DLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKTKAMLYDNPQAMH
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHH
LLLDKLAQSVTSYLNGQIQAGAQAVQIFDTWGGNLSAAAYQEFSLAYMKKIVSGLIREHD
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRKVPVILFTKNGGLWLESIAEAGADALGLDWTCDIGNARARVGDKVALQGNMDPTVLYA
CCEEEEEEEECCCCHHHHHHHHCCCCEECCEEEECCCCCHHHCCCEEEEECCCCCEEEEE
KPEAIRTEVGRILASYGKGSGHVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE
CCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA