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The map label for this gene is hom [H]

Identifier: 73541681

GI number: 73541681

Start: 2183613

End: 2184923

Strand: Reverse

Name: hom [H]

Synonym: Reut_A1993

Alternate gene names: 73541681

Gene position: 2184923-2183613 (Counterclockwise)

Preceding gene: 73541682

Following gene: 73541680

Centisome position: 57.4

GC content: 64.76

Gene sequence:

>1311_bases
ATGAACCCCATCAAAGTTGGCCTGCTCGGCATCGGTACCGTCGGTAGCGGCACGTTTAACGTGCTCAAGCGCAACCAGGA
AGAAATTCGCCGCCGCGCTGGCCGCGGCATCGAGATCGCTGTGGTGGCGGATCTCAACACCGAGCGCGCACGCGAGCTGA
CCAACGGCGAAGTCGAAATTGTCAACGACGCCAACCTGGTGGTGGCGCGCCCGGACATCGACATCGTGGTCGAGCTGATC
GGCGGCTACGGCATCGCGCGTGAGCTGGTGCTGAAGGCCATCGAGAACGGCAAGCACGTGGTCACCGCCAACAAGGCGCT
GCTGGCCGTGCACGGCAACGAGATCTTTGAAGCCGCACGCAGGAAGGGCGTGATCGTCGCGTTCGAGGCCGCAGTGGCCG
GTGGCATCCCCATCATCAAGGCACTCCGCGAAGGCCTGACCGCGAACCGCATCCAGTGGATCGCCGGCATCATCAACGGC
ACCACGAACTTCATCCTGTCCGAGATGCGCGACAAGGGCCTGGATTTCAACACGGTCCTGAAGGAAGCTCAGCAACTCGG
CTATGCCGAGGCCGATCCGACCTTCGACATCGAAGGTGTCGACGCCGCGCACAAGGTCACGCTGATGAGCGCCATCGCGT
TCGGCATGCCGGTGCAGTTCGAAAAGGCCCATGTGGAAGGCATCACCAAGCTGGCCGCGACCGACATCAAGTACGCCGAG
GAACTGGGCTACCGCATCAAGCTGCTGGGCATCACGCGCCGCCGTGACGATGGCGTGGAACTGCGCGTGCATCCGACGCT
GGTGCCAGCCTCGCGCCTGATCGCCAACGTGGAAGGCGCGATGAACGCGGTGCTGGTGCAGGGCGACGCCGTGGGCGCCA
CGCTGTACTACGGCAAGGGCGCCGGCGCCGAGCCGACCGCCTCGGCCGTGATTGCGGATCTGGTGGACGTGACCCGCCTG
CACACCGCCGACCCGAATCACCGCGTCCCGCACCTGGCGTTCCAGCCGGACGAGCTGTCGAACGTGCCGGTGCTGCCGAT
CGAGGAAATCAACAGCGCCTACTACCTGCGCATGCGCGTGTCCGACGAGACCGGCGTGCTGGCCGAGATCACGCGCATCC
TGGCCGAGGGGGGCATCTCCATCGACGCGATGCTGCAGAAGGAATCGCGCGAGGGCGAGCCGCAGACCGACATCATCATC
CTGACCCACGTGACGCGCGAGAAGCATGTCAATGCCGCCATTGCGAAGATCGAGTCGCTGCCGACTGTGCTGTCGCCGGT
CACGCGCCTGCGCATGGAAGAACTGAACTGA

Upstream 100 bases:

>100_bases
GCGCGCTTCCTGGAGGCGTATCGAAAACGCCACGGCAAGGTGGCTGCCTGATCAGGTGGCCGCTGCAACTTATCCTTAGC
AACCTAGAGTCAGATCGTCC

Downstream 100 bases:

>100_bases
TCGGCAGGATATTCCGGACCCATGAAATACCAGTCGACCCGCGGCCACGAAGTGCCGCAATCGTTCTCTGAAATCCTGCT
GGGCGGCCTGGCGCCGGACG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTNGEVEIVNDANLVVARPDIDIVVELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAARRKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFNTVLKEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFEKAHVEGITKLAATDIKYAE
ELGYRIKLLGITRRRDDGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPNHRVPHLAFQPDELSNVPVLPIEEINSAYYLRMRVSDETGVLAEITRILAEGGISIDAMLQKESREGEPQTDIII
LTHVTREKHVNAAIAKIESLPTVLSPVTRLRMEELN

Sequences:

>Translated_436_residues
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTNGEVEIVNDANLVVARPDIDIVVELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAARRKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFNTVLKEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFEKAHVEGITKLAATDIKYAE
ELGYRIKLLGITRRRDDGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPNHRVPHLAFQPDELSNVPVLPIEEINSAYYLRMRVSDETGVLAEITRILAEGGISIDAMLQKESREGEPQTDIII
LTHVTREKHVNAAIAKIESLPTVLSPVTRLRMEELN
>Mature_436_residues
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTNGEVEIVNDANLVVARPDIDIVVELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAARRKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFNTVLKEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFEKAHVEGITKLAATDIKYAE
ELGYRIKLLGITRRRDDGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPNHRVPHLAFQPDELSNVPVLPIEEINSAYYLRMRVSDETGVLAEITRILAEGGISIDAMLQKESREGEPQTDIII
LTHVTREKHVNAAIAKIESLPTVLSPVTRLRMEELN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786183, Length=254, Percent_Identity=25.1968503937008, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=129, Percent_Identity=35.6589147286822, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47143; Mature: 47143

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTNGEVEI
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEE
VNDANLVVARPDIDIVVELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAAR
EECCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECHHHHHHHH
RKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFNTVL
HCCEEEEEECHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFEKAHVEGITKLAATDIKYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
ELGYRIKLLGITRRRDDGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKG
HCCCEEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
AGAEPTASAVIADLVDVTRLHTADPNHRVPHLAFQPDELSNVPVLPIEEINSAYYLRMRV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHCCCEEEEEEEE
SDETGVLAEITRILAEGGISIDAMLQKESREGEPQTDIIILTHVTREKHVNAAIAKIESL
CCCCCHHHHHHHHHHHCCCCEEHHEEHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHC
PTVLSPVTRLRMEELN
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTNGEVEI
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEE
VNDANLVVARPDIDIVVELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAAR
EECCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECHHHHHHHH
RKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFNTVL
HCCEEEEEECHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFEKAHVEGITKLAATDIKYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
ELGYRIKLLGITRRRDDGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKG
HCCCEEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
AGAEPTASAVIADLVDVTRLHTADPNHRVPHLAFQPDELSNVPVLPIEEINSAYYLRMRV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHCCCEEEEEEEE
SDETGVLAEITRILAEGGISIDAMLQKESREGEPQTDIIILTHVTREKHVNAAIAKIESL
CCCCCHHHHHHHHHHHCCCCEEHHEEHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHC
PTVLSPVTRLRMEELN
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]