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The map label for this gene is fabG2 [H]

Identifier: 73541358

GI number: 73541358

Start: 1800164

End: 1800931

Strand: Reverse

Name: fabG2 [H]

Synonym: Reut_A1668

Alternate gene names: 73541358

Gene position: 1800931-1800164 (Counterclockwise)

Preceding gene: 73541359

Following gene: 73541357

Centisome position: 47.31

GC content: 67.32

Gene sequence:

>768_bases
ATGAAACTGACCGCAGATATGTCCGCTGTTGTGACCGGCGGCGCGTCCGGCCTGGGCCTGGCTACCGCACGCCGCCTGAT
CGAGCGCGGTGTCAGCGTGGTGATCGCCGACCTCTCCGAAGAACGCGGCAACGCCGCCCTGGACGAACTCGGTCCCAAGG
CGCGCTTCGTCAAGGCCGATGTCTGCGACACCGACCAGATGAACGCCGTCTACGACGCGGCCGAAGCGCTCGCCCCGCTG
CGCGCGCTGGTGCACTGCGCCGGTCTTGGTGCCGCGGTGCGCGTGGTCGAGAAGGACGGCTCGCCGGGTTCGCTGGAAAA
GTACGAGTCGATCGTGCGCATCAACCTGATCGGCACGTTCAATGCGCTGCGCCTGGGTGCCGCGCGCATGGCGAAGAACG
AAATGATCGACGGCGAGCGTGGTGCCTGCGTGCTGACCGCTTCGGTCGCCGCCTACGAAGGCCAGATCGGCCAGATTCCG
TATTCGTCGGCCAAGGCCGGCATCGTCGGCATGACGCTGGTGGCCGCGCGTGACCTGGCGCAGCGTGCGATCCGTGTCTG
CACGATTGCTCCGGGCCTGTTCGACACGCCGCTGCTGGCCAAGCTGCCGGAAAACGTGCGCGCCTCGCTGGGCGCGATGG
TGCCGCACCCGGCACGCCTGGGCGCGCCGGACGAGTACGCATCGACTGCCCTGCACATCCTCGAAAACATCATGCTCAAC
GGCGAAACCATTCGGCTGGATGGCGCTATTCGCATGGCCCCGCGCTGA

Upstream 100 bases:

>100_bases
GCCTGTGTACCGGTCCGTGCCGCATTTCGCGACTAGCCGTATTTCCGTATCGCTGAATCCCTGAATCCCTGAATTCCTGA
ATCAGAACTGGAGACTCAAG

Downstream 100 bases:

>100_bases
GCTGCCGGTTTCTCTTCAATACCGATTCAAGCAACACAAGGACAAGCATGAGCGACACGCTGCAACTTGAAACGCGCGGC
AATATCCTGCTGATCACGAT

Product: NAD-dependent epimerase/dehydratase:Short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MKLTADMSAVVTGGASGLGLATARRLIERGVSVVIADLSEERGNAALDELGPKARFVKADVCDTDQMNAVYDAAEALAPL
RALVHCAGLGAAVRVVEKDGSPGSLEKYESIVRINLIGTFNALRLGAARMAKNEMIDGERGACVLTASVAAYEGQIGQIP
YSSAKAGIVGMTLVAARDLAQRAIRVCTIAPGLFDTPLLAKLPENVRASLGAMVPHPARLGAPDEYASTALHILENIMLN
GETIRLDGAIRMAPR

Sequences:

>Translated_255_residues
MKLTADMSAVVTGGASGLGLATARRLIERGVSVVIADLSEERGNAALDELGPKARFVKADVCDTDQMNAVYDAAEALAPL
RALVHCAGLGAAVRVVEKDGSPGSLEKYESIVRINLIGTFNALRLGAARMAKNEMIDGERGACVLTASVAAYEGQIGQIP
YSSAKAGIVGMTLVAARDLAQRAIRVCTIAPGLFDTPLLAKLPENVRASLGAMVPHPARLGAPDEYASTALHILENIMLN
GETIRLDGAIRMAPR
>Mature_255_residues
MKLTADMSAVVTGGASGLGLATARRLIERGVSVVIADLSEERGNAALDELGPKARFVKADVCDTDQMNAVYDAAEALAPL
RALVHCAGLGAAVRVVEKDGSPGSLEKYESIVRINLIGTFNALRLGAARMAKNEMIDGERGACVLTASVAAYEGQIGQIP
YSSAKAGIVGMTLVAARDLAQRAIRVCTIAPGLFDTPLLAKLPENVRASLGAMVPHPARLGAPDEYASTALHILENIMLN
GETIRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=251, Percent_Identity=50.996015936255, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI83715985, Length=251, Percent_Identity=48.207171314741, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=26.9961977186312, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=27.0916334661355, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI31542939, Length=256, Percent_Identity=27.734375, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=199, Percent_Identity=29.6482412060301, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=29.9492385786802, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=31.0483870967742, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367175, Length=238, Percent_Identity=30.2521008403361, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=24.6031746031746, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=26.9387755102041, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=45.3125, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=29.2490118577075, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=27.0588235294118, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=51.004016064257, Blast_Score=238, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=29.2490118577075, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355319, Length=238, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26631; Mature: 26631

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTADMSAVVTGGASGLGLATARRLIERGVSVVIADLSEERGNAALDELGPKARFVKAD
CCCCCCCHHEEECCCCCCHHHHHHHHHHCCCEEEEEECHHCCCCCCHHHCCCCCEEEECC
VCDTDQMNAVYDAAEALAPLRALVHCAGLGAAVRVVEKDGSPGSLEKYESIVRINLIGTF
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHEEEEEEEECH
NALRLGAARMAKNEMIDGERGACVLTASVAAYEGQIGQIPYSSAKAGIVGMTLVAARDLA
HHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QRAIRVCTIAPGLFDTPLLAKLPENVRASLGAMVPHPARLGAPDEYASTALHILENIMLN
HHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
GETIRLDGAIRMAPR
CCEEEECCEEEECCC
>Mature Secondary Structure
MKLTADMSAVVTGGASGLGLATARRLIERGVSVVIADLSEERGNAALDELGPKARFVKAD
CCCCCCCHHEEECCCCCCHHHHHHHHHHCCCEEEEEECHHCCCCCCHHHCCCCCEEEECC
VCDTDQMNAVYDAAEALAPLRALVHCAGLGAAVRVVEKDGSPGSLEKYESIVRINLIGTF
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHEEEEEEEECH
NALRLGAARMAKNEMIDGERGACVLTASVAAYEGQIGQIPYSSAKAGIVGMTLVAARDLA
HHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QRAIRVCTIAPGLFDTPLLAKLPENVRASLGAMVPHPARLGAPDEYASTALHILENIMLN
HHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
GETIRLDGAIRMAPR
CCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]