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The map label for this gene is fadA [H]

Identifier: 73541359

GI number: 73541359

Start: 1801047

End: 1802225

Strand: Reverse

Name: fadA [H]

Synonym: Reut_A1669

Alternate gene names: 73541359

Gene position: 1802225-1801047 (Counterclockwise)

Preceding gene: 73541361

Following gene: 73541358

Centisome position: 47.35

GC content: 66.67

Gene sequence:

>1179_bases
ATGCAACAAGCCGTCATCGTCGACGCCATCCGCAGCCCGATGGGCCGCTCCAAGCCCGGTTCGGCTTTCACCGAACTGCA
TGCCACGGAACTGCTGGCCCAGGTGCTCAAGGGCCTGGTGGAGCGCAACAAGCTGGATCCGGGTCTCGTCGACGACGTCA
TCACCGGCTGCGTCACGCAGGCCGGCGAACAGTCCGCCGGCCCCGGCCGCGTGGCCTGGCTGGCGGCTGGCTTCCCTGAC
CATGTGCCCGCCACCACGATCGACCGCAAGTGCGGTTCGAGCCAGCAGGCCGTGCATTTCGCCGCGCAGGGCATCATGGC
CGGCGCCTATGACATCGTCATCGCCTGCGGCATCGAGTCGATGAGCCGCGTGCCGATGGGTTCGGCCCGTATCGGCCAGA
ACCCCTATGGCCCGTCGATGGAAGCGCGTTACGCGCCGGGTCTGGTCTCGCAGGGCGTGGCAGCGGAACTGGTTGCCGCC
AAGTACGAACTGTCCCGCGCGCAGATGGACGGCTACTCGGCTCGTTCGCACGAACTGGCCGCTGCCGCACGCGAAGCCGG
TGCATTCCGCCGCGAGATCCTGCCGATCGTGACGCCGAATGGCGTGATCGAGCACGACGAGACCATCCGCCCGGGCACTT
CGGTCGAAAAGCTTGGCACGCTGCAGGCCTCGTTCCGCAATGACGAGCTGAGCGCGCGTTTCCCGCAGATCGGCTGGAAC
GTGACGGCCGGCAATGCATCGCAGATCAGCGACGGCGCCTCGGCCATGCTTCTGATGAGCGAATCCATGGCGCAGCGCCT
GGGCCTGAAGCCGCGTGCGCGTTTCGTGGCCTTCGACGTGTGTGGCGACGATCCGGTGATGATGCTGACCGCACCGATCC
CGGCCAGCCAGCGCGCCATCAAGAAGAGCGGCCTCAAGCTCGATCAGATCGACCACTACGAAATCAATGAAGCGTTCGCT
TGCGTGCCGTTGGCCTGGCAGAAGGCGCTTGGCGCCGACGCGGCGCGGCTGAACCCGCGTGGTGGTGCGATTGCGCTGGG
CCACCCGCTCGGTGCATCGGGCGTGCGCCTGATGACCACCATGCTCCACGCATTGGAGGACAGCGGCGGCCGCTACGGCC
TGCAATCGATGTGCGAAGCCGGCGGCATGGCCAACGCCACGATCATCGAACGTCTGTAA

Upstream 100 bases:

>100_bases
CCAAATCATCGTATCGGACGATCATTTTCTGGCACCGAGGTCTCACTATCTAGCTCGTGCTGCCAACTGAAATCTGCTGC
CCTCTTACAGGAGACCCTCC

Downstream 100 bases:

>100_bases
GGCGTTGACGGACCGGCCTGTGTACCGGTCCGTGCCGCATTTCGCGACTAGCCGTATTTCCGTATCGCTGAATCCCTGAA
TCCCTGAATTCCTGAATCAG

Product: thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQQAVIVDAIRSPMGRSKPGSAFTELHATELLAQVLKGLVERNKLDPGLVDDVITGCVTQAGEQSAGPGRVAWLAAGFPD
HVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIESMSRVPMGSARIGQNPYGPSMEARYAPGLVSQGVAAELVAA
KYELSRAQMDGYSARSHELAAAAREAGAFRREILPIVTPNGVIEHDETIRPGTSVEKLGTLQASFRNDELSARFPQIGWN
VTAGNASQISDGASAMLLMSESMAQRLGLKPRARFVAFDVCGDDPVMMLTAPIPASQRAIKKSGLKLDQIDHYEINEAFA
CVPLAWQKALGADAARLNPRGGAIALGHPLGASGVRLMTTMLHALEDSGGRYGLQSMCEAGGMANATIIERL

Sequences:

>Translated_392_residues
MQQAVIVDAIRSPMGRSKPGSAFTELHATELLAQVLKGLVERNKLDPGLVDDVITGCVTQAGEQSAGPGRVAWLAAGFPD
HVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIESMSRVPMGSARIGQNPYGPSMEARYAPGLVSQGVAAELVAA
KYELSRAQMDGYSARSHELAAAAREAGAFRREILPIVTPNGVIEHDETIRPGTSVEKLGTLQASFRNDELSARFPQIGWN
VTAGNASQISDGASAMLLMSESMAQRLGLKPRARFVAFDVCGDDPVMMLTAPIPASQRAIKKSGLKLDQIDHYEINEAFA
CVPLAWQKALGADAARLNPRGGAIALGHPLGASGVRLMTTMLHALEDSGGRYGLQSMCEAGGMANATIIERL
>Mature_392_residues
MQQAVIVDAIRSPMGRSKPGSAFTELHATELLAQVLKGLVERNKLDPGLVDDVITGCVTQAGEQSAGPGRVAWLAAGFPD
HVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIESMSRVPMGSARIGQNPYGPSMEARYAPGLVSQGVAAELVAA
KYELSRAQMDGYSARSHELAAAAREAGAFRREILPIVTPNGVIEHDETIRPGTSVEKLGTLQASFRNDELSARFPQIGWN
VTAGNASQISDGASAMLLMSESMAQRLGLKPRARFVAFDVCGDDPVMMLTAPIPASQRAIKKSGLKLDQIDHYEINEAFA
CVPLAWQKALGADAARLNPRGGAIALGHPLGASGVRLMTTMLHALEDSGGRYGLQSMCEAGGMANATIIERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=36.7901234567901, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=38.0597014925373, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=35.9801488833747, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=36.0201511335013, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4504327, Length=437, Percent_Identity=32.2654462242563, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI194353979, Length=233, Percent_Identity=29.6137339055794, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=43.3915211970075, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1787663, Length=415, Percent_Identity=42.1686746987952, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=40.3465346534653, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.6551724137931, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=29.5238095238095, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=403, Percent_Identity=36.7245657568238, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=32.5062034739454, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=32.0987654320988, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=32.0366132723112, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=29.7029702970297, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=36.1809045226131, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=34.3065693430657, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=37.6237623762376, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=36.2068965517241, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=32.6436781609195, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17648125, Length=362, Percent_Identity=37.8453038674033, Blast_Score=194, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41333; Mature: 41333

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQAVIVDAIRSPMGRSKPGSAFTELHATELLAQVLKGLVERNKLDPGLVDDVITGCVTQ
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEQSAGPGRVAWLAAGFPDHVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIES
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECHHH
MSRVPMGSARIGQNPYGPSMEARYAPGLVSQGVAAELVAAKYELSRAQMDGYSARSHELA
HHCCCCCCHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AAAREAGAFRREILPIVTPNGVIEHDETIRPGTSVEKLGTLQASFRNDELSARFPQIGWN
HHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCE
VTAGNASQISDGASAMLLMSESMAQRLGLKPRARFVAFDVCGDDPVMMLTAPIPASQRAI
EECCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHH
KKSGLKLDQIDHYEINEAFACVPLAWQKALGADAARLNPRGGAIALGHPLGASGVRLMTT
HHCCCCCCCCCCEECCCHHEEHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCHHHHHHH
MLHALEDSGGRYGLQSMCEAGGMANATIIERL
HHHHHHCCCCCCCHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MQQAVIVDAIRSPMGRSKPGSAFTELHATELLAQVLKGLVERNKLDPGLVDDVITGCVTQ
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEQSAGPGRVAWLAAGFPDHVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIES
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECHHH
MSRVPMGSARIGQNPYGPSMEARYAPGLVSQGVAAELVAAKYELSRAQMDGYSARSHELA
HHCCCCCCHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AAAREAGAFRREILPIVTPNGVIEHDETIRPGTSVEKLGTLQASFRNDELSARFPQIGWN
HHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCE
VTAGNASQISDGASAMLLMSESMAQRLGLKPRARFVAFDVCGDDPVMMLTAPIPASQRAI
EECCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHH
KKSGLKLDQIDHYEINEAFACVPLAWQKALGADAARLNPRGGAIALGHPLGASGVRLMTT
HHCCCCCCCCCCEECCCHHEEHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCHHHHHHH
MLHALEDSGGRYGLQSMCEAGGMANATIIERL
HHHHHHCCCCCCCHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA