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The map label for this gene is zwf [H]

Identifier: 73541340

GI number: 73541340

Start: 1778157

End: 1779638

Strand: Reverse

Name: zwf [H]

Synonym: Reut_A1650

Alternate gene names: 73541340

Gene position: 1779638-1778157 (Counterclockwise)

Preceding gene: 73541341

Following gene: 73541339

Centisome position: 46.75

GC content: 66.19

Gene sequence:

>1482_bases
ATGGATAGCTCCAAGACCGGCGCGCAGGCCCCGGATTTCGACTTCGTATTGTTCGGCGCCACGGGCGACCTCGCGCGCCG
CAAGCTCCTGCCCGCCTTGTTCGATGCGCATGCGGCAGGCGCGCTGCATCCGCGTGGACGGATCCTCGCGCTGGGCAGCC
AGCCGCTCTCCCACGAGGCCTATCTGGCCATGCTCAACGACGAGGTACTGCCCGCGCTGGCCGGCAACGCCGTGGCCTCG
TCCTGGCCCAGCTTCGTGGAGCGAATCGTCTACCTGCAGGTGGACGCCAACGCCGAGCCGGGCTTCGATGCGTTGGCGGA
GCTGGTGAATGCCCGGGCCGCGCCGGTGGTCGTGTACTACCTGGCCACCGCCCCTCACCTCTTCGTCAGAATCTGCGAGC
AGTTGTCGCGTGTCGGCCTGACCGACCAACGCAGCCGCATCGTCCTGGAAAAGCCGTTGGGCCATGACCTGGAATCGTCC
GAGGAAATCAATTCGGCCGTGGCCAGATTCTTCGCCGAAGACCAGATCTATCGGATCGATCACTACCTGGGCAAGGAGTC
CGTACAGAACCTGATGGCAGTGCGTTTCGGCAACGTACTGTTCGAGCCCCTGTGGCGGCGCGAGTGGGTGAAGGAGGTCC
AGATCACGATCGCCGAGGAATTGGGCGTGGAGCGGCGCGGCAATTTCTACGACGGCATCGGGGCCCTGCGGGACATGGTG
CAGAACCATTTGCTGCAGCTACTGTGCATGGTCGCCATGGAACCGCCCACGAGCTTGTCCGAAGACGCCATCCGCGACGA
GAAGCTGAAAATCCTCAAGGCGCTCAAGCCGATCCGGCCCGAGACAGTGGCGGAGACGGTAGTGCGCGGCCAGTACTGCC
GCGGCGCGGCTGGCGGCGACCCGGTGCCGGGATACGTGAGCGAGCCAGGCATCCCGGCCGACAGCCGGACCGAGACCTTT
GTGGCCATCAAGGCCGAGATCGCGAACTGGCGTTGGGCCGGCGTGCCCTTCTACCTGCGCACCGGAAAACGCATGCAGTC
GCGCGTGGCGGAGATCGTCATCCACTTCCACGATGTACCCTGCGCGCTGTTCGATCGGCCGCTGGGCACGCCGGCAGGGA
ACCGGCTGGTCATCACGCTGCAGCCGGAGGAGAGCATCCGGCTTTATTTCCTGACCAAGCAACCCGGAGACACGCAGGCC
CTGGTGCCGGCCTCGCTGGATCTCCAGCGCCCAGGGACAGGCACGCGCGTGCGCCGCATGGGCGCGTACGAGCGCCTGCT
GCTCGATGTCATCCGCGGCAGGCTCGGCCTCTTCGTGCGGCGCGATGAACAGGTCCAGGCCTGGCGCTGGGTCGCACCGA
TTCTCAAGACGTGGCAGAGCACCAACACGCCGCCCAAGCTGTACACCGCCGGCACATGGGGGCCGGCGGCCTCCAGCGCC
CTGTTGTCGCGCGACGGCATGGCGTGGCATGAAGAAATGTAG

Upstream 100 bases:

>100_bases
CACGCGCGCCAATGTCCGCGATTACAAGGGCTGGGCGACCCCGAGATAGTGCGCGCCCTGCCATACCCCGAACACCTTTC
TGACCGTCCCAGGTGACATG

Downstream 100 bases:

>100_bases
TTCTGTCGTCCGAATTTCCGTTGGAGCAATCCCGATGTCGACGTCCCTCTCCGCCTGGCAATCCCTGCGCGAGCATGCCG
CCAAAATTCGCCATACCCAT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MDSSKTGAQAPDFDFVLFGATGDLARRKLLPALFDAHAAGALHPRGRILALGSQPLSHEAYLAMLNDEVLPALAGNAVAS
SWPSFVERIVYLQVDANAEPGFDALAELVNARAAPVVVYYLATAPHLFVRICEQLSRVGLTDQRSRIVLEKPLGHDLESS
EEINSAVARFFAEDQIYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVKEVQITIAEELGVERRGNFYDGIGALRDMV
QNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALKPIRPETVAETVVRGQYCRGAAGGDPVPGYVSEPGIPADSRTETF
VAIKAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVPCALFDRPLGTPAGNRLVITLQPEESIRLYFLTKQPGDTQA
LVPASLDLQRPGTGTRVRRMGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWQSTNTPPKLYTAGTWGPAASSA
LLSRDGMAWHEEM

Sequences:

>Translated_493_residues
MDSSKTGAQAPDFDFVLFGATGDLARRKLLPALFDAHAAGALHPRGRILALGSQPLSHEAYLAMLNDEVLPALAGNAVAS
SWPSFVERIVYLQVDANAEPGFDALAELVNARAAPVVVYYLATAPHLFVRICEQLSRVGLTDQRSRIVLEKPLGHDLESS
EEINSAVARFFAEDQIYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVKEVQITIAEELGVERRGNFYDGIGALRDMV
QNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALKPIRPETVAETVVRGQYCRGAAGGDPVPGYVSEPGIPADSRTETF
VAIKAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVPCALFDRPLGTPAGNRLVITLQPEESIRLYFLTKQPGDTQA
LVPASLDLQRPGTGTRVRRMGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWQSTNTPPKLYTAGTWGPAASSA
LLSRDGMAWHEEM
>Mature_493_residues
MDSSKTGAQAPDFDFVLFGATGDLARRKLLPALFDAHAAGALHPRGRILALGSQPLSHEAYLAMLNDEVLPALAGNAVAS
SWPSFVERIVYLQVDANAEPGFDALAELVNARAAPVVVYYLATAPHLFVRICEQLSRVGLTDQRSRIVLEKPLGHDLESS
EEINSAVARFFAEDQIYRIDHYLGKESVQNLMAVRFGNVLFEPLWRREWVKEVQITIAEELGVERRGNFYDGIGALRDMV
QNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALKPIRPETVAETVVRGQYCRGAAGGDPVPGYVSEPGIPADSRTETF
VAIKAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVPCALFDRPLGTPAGNRLVITLQPEESIRLYFLTKQPGDTQA
LVPASLDLQRPGTGTRVRRMGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWQSTNTPPKLYTAGTWGPAASSA
LLSRDGMAWHEEM

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=36.1746361746362, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=36.1746361746362, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI52145310, Length=497, Percent_Identity=27.364185110664, Blast_Score=155, Evalue=9e-38,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=45.2083333333333, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=35.5691056910569, Blast_Score=302, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=480, Percent_Identity=36.25, Blast_Score=293, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=35.2697095435685, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=35.2697095435685, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI221513548, Length=497, Percent_Identity=29.7786720321932, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54811; Mature: 54811

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSKTGAQAPDFDFVLFGATGDLARRKLLPALFDAHAAGALHPRGRILALGSQPLSHEA
CCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHH
YLAMLNDEVLPALAGNAVASSWPSFVERIVYLQVDANAEPGFDALAELVNARAAPVVVYY
HHHHHCCHHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEE
LATAPHLFVRICEQLSRVGLTDQRSRIVLEKPLGHDLESSEEINSAVARFFAEDQIYRID
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
HYLGKESVQNLMAVRFGNVLFEPLWRREWVKEVQITIAEELGVERRGNFYDGIGALRDMV
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALKPIRPETVAETVVRGQYCRGAAGGD
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
PVPGYVSEPGIPADSRTETFVAIKAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVP
CCCCCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCEECCCHHHHHHHHHHHHHHCCCC
CALFDRPLGTPAGNRLVITLQPEESIRLYFLTKQPGDTQALVPASLDLQRPGTGTRVRRM
HHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHH
GAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWQSTNTPPKLYTAGTWGPAASSA
HHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHH
LLSRDGMAWHEEM
HHHCCCCCHHCCC
>Mature Secondary Structure
MDSSKTGAQAPDFDFVLFGATGDLARRKLLPALFDAHAAGALHPRGRILALGSQPLSHEA
CCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHH
YLAMLNDEVLPALAGNAVASSWPSFVERIVYLQVDANAEPGFDALAELVNARAAPVVVYY
HHHHHCCHHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEE
LATAPHLFVRICEQLSRVGLTDQRSRIVLEKPLGHDLESSEEINSAVARFFAEDQIYRID
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
HYLGKESVQNLMAVRFGNVLFEPLWRREWVKEVQITIAEELGVERRGNFYDGIGALRDMV
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QNHLLQLLCMVAMEPPTSLSEDAIRDEKLKILKALKPIRPETVAETVVRGQYCRGAAGGD
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
PVPGYVSEPGIPADSRTETFVAIKAEIANWRWAGVPFYLRTGKRMQSRVAEIVIHFHDVP
CCCCCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCEECCCHHHHHHHHHHHHHHCCCC
CALFDRPLGTPAGNRLVITLQPEESIRLYFLTKQPGDTQALVPASLDLQRPGTGTRVRRM
HHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHH
GAYERLLLDVIRGRLGLFVRRDEQVQAWRWVAPILKTWQSTNTPPKLYTAGTWGPAASSA
HHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHH
LLSRDGMAWHEEM
HHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]