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The map label for this gene is pgi

Identifier: 73541339

GI number: 73541339

Start: 1776494

End: 1778122

Strand: Reverse

Name: pgi

Synonym: Reut_A1649

Alternate gene names: 73541339

Gene position: 1778122-1776494 (Counterclockwise)

Preceding gene: 73541340

Following gene: 73541338

Centisome position: 46.71

GC content: 66.67

Gene sequence:

>1629_bases
ATGTCGACGTCCCTCTCCGCCTGGCAATCCCTGCGCGAGCATGCCGCCAAAATTCGCCATACCCATATGCGTGACTGGTT
CACGGGTCCGCAGGGCCAGGCGCGCTCCGTGCGCCTGACCGTTGAGGCCTGCGGTCTGACCCTTGACTACGCCAAGAACC
GCGTCACCGAAGACACCCTGTCGCTGCTGTTCGCACTCGCCCGCCAGGCTCGCGTTTGCGAGCGGCGCGATGCCATGTTT
GCCGGCGAGCCGGTCAACACCACGGAGCGCCGCGCTGCGCTCCATATGGCGCTGCGCGCTCACCCCGGTGACGGCTACCG
CGCACTGGGCGTGCCGGTGGAGGCCGATGTATCCGCCGTGCTGGCGCAGATGGAACGCTTCGCGCGAGACGTGCGCAGCG
GCAGCTGGACCGGCTTTGATGGACGCGCCATCACGGATGTGGTCAACATCGGCATCGGCGGTTCCGACCTCGGGCCGCGT
ATGGTGTGCCGCGCGCTGGAGCAGGACACAGAACCGGGGCCCCGCCTGCATTTCGTCGCCAACGTGGACGGCTACGACCT
GGCCCGCACGCTGGCTCGCCTCGATGCCGCCACCACGCTGGTGATCGTCTGCTCCAAGACGTTCACCACGCTGGAAACAA
TGGCCAACGCCCGCACCGCGCGCGACTGGTTCCTGCGCCATGGCGTCACACACTCGGACCTGGCGCGCCACTTTGTGGCC
GTGTCGACGAACCGGGACGCCGTGGCGGCGTTCGGCATCGACCCCGTCAACATGTTCCCGTTCTGGGACTGGGTGGGCGG
GCGCTTCTCGCTGTGGTCGGCGGTTGGCCTGTCGATCGCGGTGGCGATCGGCTTTGACAGGTTCCGCCAGTTGCTGGATG
GCGCACGCGCCATGGACCGGCATTTCGCCGGCGCGCCGCCCGAACAGAACCTGCCGATGATCCTGGGCCTGCTGGATGTC
TGGTATCGCAGCTTCCTCGGCACCGCCAGCCGCTGCGTCGCGCCGTATTGCGAGCCGCTGGACCTGCTGCCGGCGTTCCT
GCAGCAGCTCGAAATGGAGAGCAACGGGAAGTCGGTGCAGCACGACGGTGCGGCGCTGGAGGCCGGTTCGGCTGCGGTCG
TATGGGGCACCACCGGCACCAATGGCCAGCATGCCTATTTCCAGATGGTCCACCAGGGCTCGCAGCTCGTACCGGTGGAC
TTTATCGCTTGCCTGCAACCGCACAGCGACCTGCCCGGCCACCATACCAAGCTGCTGGCAAATTGCTTTGCGCAGGGAGA
AGCGCTGCTGCGCGGGCGCACCGCCGACGAAGTACGCGCCGAGGGGAAGGCTGACGAGGCGCTGGTGCCGCATCTGGTAT
TTGAAGGGAACCGCCCCAGCAATACGTTGCTGCTGCAGCGGCTGGATGCGTTCCACCTCGGCGCCTTGCTCGCGATGTCG
GAACATCGCACCTTTGTGCAAGGCGCGCTTTGGAACATCAATCCCTTCGATCAATGGGGCGTGGAACTTGGCAAGATGCT
GGCCCGTCCCATCGAGCGCGAACTGGAAGGAGCGCCCCCGCAGCCGCATGACGCGTCGACGGCCGCGCTGATCCGCCGCG
CCGCACAGTTTTGTGCAAGCACAGACTAG

Upstream 100 bases:

>100_bases
TGGGGGCCGGCGGCCTCCAGCGCCCTGTTGTCGCGCGACGGCATGGCGTGGCATGAAGAAATGTAGTTCTGTCGTCCGAA
TTTCCGTTGGAGCAATCCCG

Downstream 100 bases:

>100_bases
GAGACACGGATGTCAAGACCCCTGCCCCGCTACGTCGTGTTCGGTGAGGCGCTCACCGACATGGTGCTCCAGGCCGACGG
CAACTGGCTCGGCCTGCCAG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI 2; Phosphoglucose isomerase 2; PGI 2; Phosphohexose isomerase 2; PHI 2

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSTSLSAWQSLREHAAKIRHTHMRDWFTGPQGQARSVRLTVEACGLTLDYAKNRVTEDTLSLLFALARQARVCERRDAMF
AGEPVNTTERRAALHMALRAHPGDGYRALGVPVEADVSAVLAQMERFARDVRSGSWTGFDGRAITDVVNIGIGGSDLGPR
MVCRALEQDTEPGPRLHFVANVDGYDLARTLARLDAATTLVIVCSKTFTTLETMANARTARDWFLRHGVTHSDLARHFVA
VSTNRDAVAAFGIDPVNMFPFWDWVGGRFSLWSAVGLSIAVAIGFDRFRQLLDGARAMDRHFAGAPPEQNLPMILGLLDV
WYRSFLGTASRCVAPYCEPLDLLPAFLQQLEMESNGKSVQHDGAALEAGSAAVVWGTTGTNGQHAYFQMVHQGSQLVPVD
FIACLQPHSDLPGHHTKLLANCFAQGEALLRGRTADEVRAEGKADEALVPHLVFEGNRPSNTLLLQRLDAFHLGALLAMS
EHRTFVQGALWNINPFDQWGVELGKMLARPIERELEGAPPQPHDASTAALIRRAAQFCASTD

Sequences:

>Translated_542_residues
MSTSLSAWQSLREHAAKIRHTHMRDWFTGPQGQARSVRLTVEACGLTLDYAKNRVTEDTLSLLFALARQARVCERRDAMF
AGEPVNTTERRAALHMALRAHPGDGYRALGVPVEADVSAVLAQMERFARDVRSGSWTGFDGRAITDVVNIGIGGSDLGPR
MVCRALEQDTEPGPRLHFVANVDGYDLARTLARLDAATTLVIVCSKTFTTLETMANARTARDWFLRHGVTHSDLARHFVA
VSTNRDAVAAFGIDPVNMFPFWDWVGGRFSLWSAVGLSIAVAIGFDRFRQLLDGARAMDRHFAGAPPEQNLPMILGLLDV
WYRSFLGTASRCVAPYCEPLDLLPAFLQQLEMESNGKSVQHDGAALEAGSAAVVWGTTGTNGQHAYFQMVHQGSQLVPVD
FIACLQPHSDLPGHHTKLLANCFAQGEALLRGRTADEVRAEGKADEALVPHLVFEGNRPSNTLLLQRLDAFHLGALLAMS
EHRTFVQGALWNINPFDQWGVELGKMLARPIERELEGAPPQPHDASTAALIRRAAQFCASTD
>Mature_541_residues
STSLSAWQSLREHAAKIRHTHMRDWFTGPQGQARSVRLTVEACGLTLDYAKNRVTEDTLSLLFALARQARVCERRDAMFA
GEPVNTTERRAALHMALRAHPGDGYRALGVPVEADVSAVLAQMERFARDVRSGSWTGFDGRAITDVVNIGIGGSDLGPRM
VCRALEQDTEPGPRLHFVANVDGYDLARTLARLDAATTLVIVCSKTFTTLETMANARTARDWFLRHGVTHSDLARHFVAV
STNRDAVAAFGIDPVNMFPFWDWVGGRFSLWSAVGLSIAVAIGFDRFRQLLDGARAMDRHFAGAPPEQNLPMILGLLDVW
YRSFLGTASRCVAPYCEPLDLLPAFLQQLEMESNGKSVQHDGAALEAGSAAVVWGTTGTNGQHAYFQMVHQGSQLVPVDF
IACLQPHSDLPGHHTKLLANCFAQGEALLRGRTADEVRAEGKADEALVPHLVFEGNRPSNTLLLQRLDAFHLGALLAMSE
HRTFVQGALWNINPFDQWGVELGKMLARPIERELEGAPPQPHDASTAALIRRAAQFCASTD

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=540, Percent_Identity=48.1481481481481, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI296080693, Length=540, Percent_Identity=44.4444444444444, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1790457, Length=539, Percent_Identity=47.6808905380334, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71996708, Length=494, Percent_Identity=49.1902834008097, Blast_Score=493, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71996703, Length=494, Percent_Identity=49.1902834008097, Blast_Score=493, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6319673, Length=545, Percent_Identity=46.7889908256881, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24651916, Length=541, Percent_Identity=48.6136783733826, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24651914, Length=541, Percent_Identity=48.6136783733826, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI17737445, Length=541, Percent_Identity=48.6136783733826, Blast_Score=509, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI2_CUPPJ (Q471B8)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_295859.1
- ProteinModelPortal:   Q471B8
- SMR:   Q471B8
- GeneID:   3610248
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A1649
- NMPDR:   fig|264198.3.peg.2091
- HOGENOM:   HBG352954
- OMA:   ADINEIS
- ProtClustDB:   PRK00179
- BioCyc:   REUT264198:REUT_A1649-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59420; Mature: 59289

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: ACT_SITE 353-353 ACT_SITE 384-384 ACT_SITE 505-505

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSLSAWQSLREHAAKIRHTHMRDWFTGPQGQARSVRLTVEACGLTLDYAKNRVTEDTL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCEEHHHHHCCCCHHHH
SLLFALARQARVCERRDAMFAGEPVNTTERRAALHMALRAHPGDGYRALGVPVEADVSAV
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHH
LAQMERFARDVRSGSWTGFDGRAITDVVNIGIGGSDLGPRMVCRALEQDTEPGPRLHFVA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
NVDGYDLARTLARLDAATTLVIVCSKTFTTLETMANARTARDWFLRHGVTHSDLARHFVA
CCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEE
VSTNRDAVAAFGIDPVNMFPFWDWVGGRFSLWSAVGLSIAVAIGFDRFRQLLDGARAMDR
EECCCCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFAGAPPEQNLPMILGLLDVWYRSFLGTASRCVAPYCEPLDLLPAFLQQLEMESNGKSVQ
HCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
HDGAALEAGSAAVVWGTTGTNGQHAYFQMVHQGSQLVPVDFIACLQPHSDLPGHHTKLLA
CCCCEEECCCEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
NCFAQGEALLRGRTADEVRAEGKADEALVPHLVFEGNRPSNTLLLQRLDAFHLGALLAMS
HHHHCCHHHHCCCCHHHHHCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
EHRTFVQGALWNINPFDQWGVELGKMLARPIERELEGAPPQPHDASTAALIRRAAQFCAS
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
TD
CC
>Mature Secondary Structure 
STSLSAWQSLREHAAKIRHTHMRDWFTGPQGQARSVRLTVEACGLTLDYAKNRVTEDTL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCEEHHHHHCCCCHHHH
SLLFALARQARVCERRDAMFAGEPVNTTERRAALHMALRAHPGDGYRALGVPVEADVSAV
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHH
LAQMERFARDVRSGSWTGFDGRAITDVVNIGIGGSDLGPRMVCRALEQDTEPGPRLHFVA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
NVDGYDLARTLARLDAATTLVIVCSKTFTTLETMANARTARDWFLRHGVTHSDLARHFVA
CCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEE
VSTNRDAVAAFGIDPVNMFPFWDWVGGRFSLWSAVGLSIAVAIGFDRFRQLLDGARAMDR
EECCCCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFAGAPPEQNLPMILGLLDVWYRSFLGTASRCVAPYCEPLDLLPAFLQQLEMESNGKSVQ
HCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
HDGAALEAGSAAVVWGTTGTNGQHAYFQMVHQGSQLVPVDFIACLQPHSDLPGHHTKLLA
CCCCEEECCCEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
NCFAQGEALLRGRTADEVRAEGKADEALVPHLVFEGNRPSNTLLLQRLDAFHLGALLAMS
HHHHCCHHHHCCCCHHHHHCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
EHRTFVQGALWNINPFDQWGVELGKMLARPIERELEGAPPQPHDASTAALIRRAAQFCAS
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
TD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA