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The map label for this gene is glxR [H]

Identifier: 73541191

GI number: 73541191

Start: 1620411

End: 1621310

Strand: Direct

Name: glxR [H]

Synonym: Reut_A1500

Alternate gene names: 73541191

Gene position: 1620411-1621310 (Clockwise)

Preceding gene: 73541190

Following gene: 73541192

Centisome position: 42.57

GC content: 63.56

Gene sequence:

>900_bases
ATGAGCAAGATCGGATTCATCGGACTCGGTGTCATGGGCAAGCCCATGGCGGAACACCTGCAGGCGGGCGGCCATATCGT
CTATGCGCACACGCGCAGCGGCGTGCCGCAGGAACTGCTCGACAAGGGCATGCAATCCTGCTCCAGTGCCGCGGATGTGG
CCCGGCAGGCCGAAGTCATTTTCCTGATGCTGCCGGACACGCCCGATGTGGCCCGCGTGCTGTTCGACAAGAATGGCGTG
GCCGAGGGCCTGAGCGCGGGCAAGATCGTCGTGGACATGAGTTCGATCTCGCCGATCGAGACCCGCGAATTCGCGGCGAA
GATCGAGAAGCTCGGCTGCAACTATGTGGACGCACCGGTGTCCGGCGGCGAGGTGGGCGCGAAGGCCGCCACGCTGTCGA
TCATGGCCGGCGGCAAGCAGGATGTGTTCGACAAGGTGCTGCCTTTGCTGCAGCTGATGGGCAAGAACATCACGCTGGTG
GGCAATGCCGGTGACGGGCAGGTGGCCAAGGTGGCCAACCAGGTGATCGTGGCGCTAACGATCGAGGCTGTCAGCGAGGC
ACTGGTGCTGGCCGCCAAGGCCGGCGCCGACCCGGCACGCGTGCGCCAGGCCTTGATGGGCGGTTTTGCCAGTTCGAAGA
TCCTGGAAGTCCACGGTGAACGGATGATCCAGCGCACGTTCAATCCGGGCTTCCGCATCGAGCTGCACCAGAAGGACCTG
AACCTGGCGCTGTCGACGGCAAAGCAGCTTGGGCTGGGCTTGCCGAATACGGCATCGACCCAGCAACTGTTCAACGTCTG
CGTGGCGCAGGGCGGGGCTGGCTGGGATCATTCAGGGCTGGTCAAGGCCATCGAGCATCTGTCGAGTTTTGCCATTGGCG
ATACGCCGAAAAAGGCCTGA

Upstream 100 bases:

>100_bases
ATTTCGTCGCCGTCGGACTGGATCACGTACTGTTGCGCGATGCGGCGCGCGCGCTGCGCGAGCGTTTCGCGTCCTGACAC
GACTTCAACCGGACACAGAC

Downstream 100 bases:

>100_bases
TGCCGCGATGACGTCCGCGCTGAATTCCGACGACCTGGCGAGCTTTGTCTGCGTGGCCAACGCGCAAAGCATCTCGCGCG
CCGCGCTGGAACTTGGTGCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSKIGFIGLGVMGKPMAEHLQAGGHIVYAHTRSGVPQELLDKGMQSCSSAADVARQAEVIFLMLPDTPDVARVLFDKNGV
AEGLSAGKIVVDMSSISPIETREFAAKIEKLGCNYVDAPVSGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLV
GNAGDGQVAKVANQVIVALTIEAVSEALVLAAKAGADPARVRQALMGGFASSKILEVHGERMIQRTFNPGFRIELHQKDL
NLALSTAKQLGLGLPNTASTQQLFNVCVAQGGAGWDHSGLVKAIEHLSSFAIGDTPKKA

Sequences:

>Translated_299_residues
MSKIGFIGLGVMGKPMAEHLQAGGHIVYAHTRSGVPQELLDKGMQSCSSAADVARQAEVIFLMLPDTPDVARVLFDKNGV
AEGLSAGKIVVDMSSISPIETREFAAKIEKLGCNYVDAPVSGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLV
GNAGDGQVAKVANQVIVALTIEAVSEALVLAAKAGADPARVRQALMGGFASSKILEVHGERMIQRTFNPGFRIELHQKDL
NLALSTAKQLGLGLPNTASTQQLFNVCVAQGGAGWDHSGLVKAIEHLSSFAIGDTPKKA
>Mature_298_residues
SKIGFIGLGVMGKPMAEHLQAGGHIVYAHTRSGVPQELLDKGMQSCSSAADVARQAEVIFLMLPDTPDVARVLFDKNGVA
EGLSAGKIVVDMSSISPIETREFAAKIEKLGCNYVDAPVSGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLVG
NAGDGQVAKVANQVIVALTIEAVSEALVLAAKAGADPARVRQALMGGFASSKILEVHGERMIQRTFNPGFRIELHQKDLN
LALSTAKQLGLGLPNTASTQQLFNVCVAQGGAGWDHSGLVKAIEHLSSFAIGDTPKKA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=308, Percent_Identity=31.4935064935065, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=25.9649122807018, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=62.3693379790941, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=42.9553264604811, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=31.9444444444444, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=284, Percent_Identity=31.3380281690141, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24655230, Length=261, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI19922568, Length=261, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI28574115, Length=263, Percent_Identity=27.3764258555133, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31207; Mature: 31075

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIGFIGLGVMGKPMAEHLQAGGHIVYAHTRSGVPQELLDKGMQSCSSAADVARQAEVI
CCCCCEEECCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
FLMLPDTPDVARVLFDKNGVAEGLSAGKIVVDMSSISPIETREFAAKIEKLGCNYVDAPV
EEECCCCCHHHHHHHCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEECCCC
SGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLVGNAGDGQVAKVANQVIVALT
CCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHEEE
IEAVSEALVLAAKAGADPARVRQALMGGFASSKILEVHGERMIQRTFNPGFRIELHQKDL
HHHHHHHHHHHHHCCCCHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCH
NLALSTAKQLGLGLPNTASTQQLFNVCVAQGGAGWDHSGLVKAIEHLSSFAIGDTPKKA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SKIGFIGLGVMGKPMAEHLQAGGHIVYAHTRSGVPQELLDKGMQSCSSAADVARQAEVI
CCCCEEECCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
FLMLPDTPDVARVLFDKNGVAEGLSAGKIVVDMSSISPIETREFAAKIEKLGCNYVDAPV
EEECCCCCHHHHHHHCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEECCCC
SGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLVGNAGDGQVAKVANQVIVALT
CCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHEEE
IEAVSEALVLAAKAGADPARVRQALMGGFASSKILEVHGERMIQRTFNPGFRIELHQKDL
HHHHHHHHHHHHHCCCCHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCH
NLALSTAKQLGLGLPNTASTQQLFNVCVAQGGAGWDHSGLVKAIEHLSSFAIGDTPKKA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]