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The map label for this gene is yngE [H]

Identifier: 73541159

GI number: 73541159

Start: 1584565

End: 1586172

Strand: Reverse

Name: yngE [H]

Synonym: Reut_A1465

Alternate gene names: 73541159

Gene position: 1586172-1584565 (Counterclockwise)

Preceding gene: 73541160

Following gene: 73541158

Centisome position: 41.67

GC content: 64.12

Gene sequence:

>1608_bases
ATGCCGACCTTAGAAACCAAACTCAACGCGCGCTCCGAATCGTTCAAGTCGAATGCCGAAGCCATGCAGGCGCTGGTCGC
CGACCTCAAGGCCAAGGTCGCCAAGCTCGCCGAAGGCGGCGGCGATGCCGCGCGCGACAAGCACCTGTCGCGCGGCAAGC
TGCTGCCGCGCGATCGCGTGCAGCAACTACTGGACCCCGGCACGCCGTTCCTGGAACTGTCGCAGCTCGCCGCGTACGAC
ATGTACGACAACGCCGCGCCGGGCGCGGGCATCATCACCGGCATCGGGCGCGTGGCCGGGCAGGAATGCGTGATCGTCTG
CAACGACGCGACCGTCAAGGGCGGCACGTATTACCCGATGACGGTCAAGAAGCACGTGCGTGCACAGGAGATCGCCGAGC
AGAACAACCTGCCGTGCATCTATCTGGTGGACTCGGGCGGTGCGAACCTGCCGAACCAGGACGATGTATTCCCCGACCGC
GATCACTTCGGGCGCATCTTCTACAACCAGGCCAACCTGTCCAAGCAGGGCATCCCGCAGATCGCCGTGGTGATGGGCTC
TTGCACGGCCGGCGGCGCCTATGTGCCGGCAATGAGCGATGAGTCGATCATCGTCAAGAACCAGGGCACGATTTTCCTCG
GCGGCCCACCGCTGGTGAAGGCCGCTACGGGCGAAGAAGTCACGGCCGAAGATCTCGGCGGCGCCGATGTGCATACGCGC
CTGTCAGGCGTGGCGGATTACTTCGCGCAGAACGATCATCACGCGCTGTCGCTGGCCCGGAACATCGTGCAGCACCTGAA
CCGGCGCAAGCCCGACCAGATCCGCCTGCATGCGCCGGCCGATCCGCTGTATCCGGTAGAAGAACTGTACGGGGTGATCC
CGACCGATACGCGCAAGCCGTTCGATGTACGCGAGGTCATCTCGCGCATTGTAGATGGCTCCGAGTTCGACGAATTCAAG
GCGCGCTATGGCACGACGCTCGTCTGCGGCTTCGCACGCATCTGGGGCTACCCGGTCGGCATCATCGCCAACAACGGTAT
CCTGTTTTCCGAATCGGCGCTCAAGGGCGCGCACTTCATCGAACTGTGCTGCCAGCGCAAGATTCCGCTGGTGTTCCTGC
AGAACATCACGGGCTTCATGGTAGGCCGCAAGTACGAGAACGAAGGTATCGCACGCAATGGCGCCAAGATGGTCACGGCG
GTCGCCACGGCACAGGTGCCGAAGTTCACGGTGATCATCGGCGGCTCGTTCGGTGCAGGCAACTACGGCATGTGCGGCCG
TGCGTATTCGCCGCGCTTCCTGTGGATGTGGCCGAACGCGCGTATCTCCGTGATGGGCGGCGAGCAGGCCGCAAGCGTGC
TGGCGACGGTGCGCCGCGACGGCATCGAGGCCAAGGGCGGTAATTGGAGCGCGGAGGAAGAAGAGGCATTCAAGCAGCCG
ATCCGCGACCAGTACGAGCATCAGGGTCATCCGTACTACGCGAGCGCGCGGCTGTGGGACGACGGGGTCATCGATCCCGC
GCAGACGCGCACGGTGCTCGGGCTGGGCCTGTCGGCCAGCCTCAACGCGCCGATCGACGACATGAAGTTCGGCGTGTTCC
GCATGTAA

Upstream 100 bases:

>100_bases
TCGGCCGCGAGCTGTTTGCCGAAACGGCCTGATCCGCAACCGACGCCCCCACTGCCCGCCCTGCCGGCGGCCCGACCAGA
ACAAGACTGCCCAAGATCGT

Downstream 100 bases:

>100_bases
GCCGGCCCCCGACCAACGCACATTCAAGCCATACCGCCATGGAATTCACCACGCTTACCGTCACCATCGCCCGGCATGTC
GCGACCGTGACGCTGAACCG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRVQQLLDPGTPFLELSQLAAYD
MYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDR
DHFGRIFYNQANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHAPADPLYPVEELYGVIPTDTRKPFDVREVISRIVDGSEFDEFK
ARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNWSAEEEEAFKQP
IRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM

Sequences:

>Translated_535_residues
MPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRVQQLLDPGTPFLELSQLAAYD
MYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDR
DHFGRIFYNQANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHAPADPLYPVEELYGVIPTDTRKPFDVREVISRIVDGSEFDEFK
ARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNWSAEEEEAFKQP
IRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM
>Mature_534_residues
PTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRVQQLLDPGTPFLELSQLAAYDM
YDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDRD
HFGRIFYNQANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTRL
SGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHAPADPLYPVEELYGVIPTDTRKPFDVREVISRIVDGSEFDEFKA
RYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNWSAEEEEAFKQPI
RDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=534, Percent_Identity=67.0411985018727, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=526, Percent_Identity=33.2699619771863, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI295821216, Length=546, Percent_Identity=32.0512820512821, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI310133460, Length=144, Percent_Identity=59.7222222222222, Blast_Score=156, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=63.1086142322097, Blast_Score=724, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=484, Percent_Identity=34.504132231405, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25147359, Length=484, Percent_Identity=34.9173553719008, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=64.4283121597096, Blast_Score=734, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58112; Mature: 57981

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRV
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHH
QQLLDPGTPFLELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEECCCEECCC
TVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDRDHFGRIFYNQANLSKQGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCCCCHHHCCCCHHHHH
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHAPADPLYPVEELYGVIPTDTRKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCC
FDVREVISRIVDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEECHHHCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHHCCEECCCCCCCCCCHHEEHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNWSAEEEEAFKQP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
IRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM
HHHHHHHCCCCEEEEEEECCCCCCCCHHHCEEEEECCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
PTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRV
CCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHH
QQLLDPGTPFLELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEECCCEECCC
TVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDRDHFGRIFYNQANLSKQGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCCCCHHHCCCCHHHHH
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHAPADPLYPVEELYGVIPTDTRKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCC
FDVREVISRIVDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEECHHHCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHHCCEECCCCCCCCCCHHEEHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNWSAEEEEAFKQP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
IRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM
HHHHHHHCCCCEEEEEEECCCCCCCCHHHCEEEEECCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]