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The map label for this gene is acdA [H]

Identifier: 73541160

GI number: 73541160

Start: 1586241

End: 1587422

Strand: Reverse

Name: acdA [H]

Synonym: Reut_A1466

Alternate gene names: 73541160

Gene position: 1587422-1586241 (Counterclockwise)

Preceding gene: 73541161

Following gene: 73541159

Centisome position: 41.7

GC content: 64.64

Gene sequence:

>1182_bases
ATGACCCAACTCCCTGGCCTGAGATTCGACCTGGGCGAAGATATCGAGATGCTGCGCAGCGCCGTGCGCGACTGGGCCCA
GGCCGAACTGGCACCGCGCGCCGGCGAGATCGACCGCACCGATCAGTTTCCGATGGACGCCTGGAAGAAGATGGGCGACC
TCGGCGTGCTCGGCATCACGGTGGCCGAGGAATACGGCGGCGCCAATATGGGCTACCTCGCCCACATGGTGGCGATGGAG
GAAATCAGCCGCGCTTCGGCGTCGGTCGGCTTGTCCTACGGGGCGCATTCGAACCTGTGCGTGAACCAGATCCACCGCAA
CGGTACGGCCGCGCAGAAGGCGAAGTACCTGCCCAAGCTGGTCTCCGGTGATTGGATCGGCGCACTGGCGATGAGCGAGC
CCAATGCAGGCTCCGACGTGGTCAGCATGAAGCTGCGCGCCGAACGCAAGGGCGACCGCTACGTGCTCAACGGCACCAAG
ATGTGGATCACCAATGGCCCGGACTGCGACGTGCTCGTGGTCTACGCCAAGACCGAACCGGAACTCGGCGCGCGCGGCAT
GACCGCGTTCATTGTCGAGAAAGGCATGAAGGGCTTCTCGGTTGCGCAGAAGCTCGACAAGCTCGGCATGCGCGGCTCGC
ACACCGGCGAGCTGGTGTTCGAGGACGTGGAAGTTCCCGCCGAGAACATCCTCGGCGCGGAGAACGGCGGCGCCAAGGTG
CTGATGAGCGGTCTCGACTACGAGCGCGCGGTGCTGTCGGGTGGCCCGATCGGCATCATGCAGGCTTGCATGGATGTGGT
CACCCCGTACATCCACGATCGCAAGCAGTTTGGCCAGAGCATCGGCGAGTTCCAGCTGATCCAGGGCAAGGTCGCCGACA
TGTACACCACGCTCCAGGCGGCACGCAGCTACCTGTACACGGTCGGCAAGAACCTGGATTCGCTGGGCAGCGACCACGTG
CGCCAGGTGCGCAAGGACTGCGCAGCAGTGATCCTGTACACGGCCGAGAAGGCCACGTGGATGGCCGGCGAAACGGTGCA
GATCCTCGGCGGCAACGGCTATATCAACGAGTACCCGGCCGGCCGCCTGTGGCGCGATGCCAAGCTGTATGAGATCGGTG
CCGGCACCTCGGAAATCCGCCGCATGCTGATCGGCCGCGAGCTGTTTGCCGAAACGGCCTGA

Upstream 100 bases:

>100_bases
AGTTCGTCATGCGCGAACGCATGACGAAGGAACTGAACCTCACCGAAAGCAAGACCGCCTGACCACGGCGCCCCACACAC
ATCTACGGAAGAACACGATC

Downstream 100 bases:

>100_bases
TCCGCAACCGACGCCCCCACTGCCCGCCCTGCCGGCGGCCCGACCAGAACAAGACTGCCCAAGATCGTATGCCGACCTTA
GAAACCAAACTCAACGCGCG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTQLPGLRFDLGEDIEMLRSAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGITVAEEYGGANMGYLAHMVAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGDWIGALAMSEPNAGSDVVSMKLRAERKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPAENILGAENGGAKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGSDHV
RQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPAGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA

Sequences:

>Translated_393_residues
MTQLPGLRFDLGEDIEMLRSAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGITVAEEYGGANMGYLAHMVAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGDWIGALAMSEPNAGSDVVSMKLRAERKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPAENILGAENGGAKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGSDHV
RQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPAGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
>Mature_392_residues
TQLPGLRFDLGEDIEMLRSAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGITVAEEYGGANMGYLAHMVAMEE
ISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGDWIGALAMSEPNAGSDVVSMKLRAERKGDRYVLNGTKM
WITNGPDCDVLVVYAKTEPELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPAENILGAENGGAKVL
MSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGSDHVR
QVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPAGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=62.5974025974026, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=65.606936416185, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=40, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=34.1333333333333, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=34.2857142857143, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=34.2857142857143, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4501857, Length=390, Percent_Identity=32.8205128205128, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI21361497, Length=394, Percent_Identity=36.2944162436548, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=34.3023255813954, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4557235, Length=344, Percent_Identity=34.3023255813954, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=29.6103896103896, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=32.7319587628866, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI7669494, Length=357, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=25.3472222222222, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=25.3472222222222, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=21.4035087719298, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=28.0927835051546, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.4611398963731, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI87082384, Length=253, Percent_Identity=24.901185770751, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=61.7571059431525, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=34.8404255319149, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=397, Percent_Identity=35.0125944584383, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17534899, Length=390, Percent_Identity=34.6153846153846, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=393, Percent_Identity=33.8422391857506, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=31.7708333333333, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=30.6282722513089, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=38.3211678832117, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=33.8028169014084, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.8268398268398, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=31.0704960835509, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.5766423357664, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=36.9718309859155, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=364, Percent_Identity=31.3186813186813, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=27.9569892473118, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=28.2786885245902, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=21.5277777777778, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=63.7532133676092, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21356377, Length=383, Percent_Identity=39.4255874673629, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=36.4829396325459, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=34.5549738219895, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=34.1085271317829, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI281363737, Length=367, Percent_Identity=34.6049046321526, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=31.4432989690722, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24652780, Length=316, Percent_Identity=22.1518987341772, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42765; Mature: 42633

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLPGLRFDLGEDIEMLRSAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGIT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGDWIGALAMSEPNAGSDVVSMKLRAERKGDRYVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEECCCC
ELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPAENILGAENGGAKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCCEE
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQA
EEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
ARSYLYTVGKNLDSLGSDHVRQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPA
HHHHHHHHHCCHHHCCHHHHHHHHHHHHEEEEEECCCCEEECCCEEEEEECCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQLPGLRFDLGEDIEMLRSAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGDWIGALAMSEPNAGSDVVSMKLRAERKGDRYVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEECCCC
ELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPAENILGAENGGAKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCCEE
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQA
EEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
ARSYLYTVGKNLDSLGSDHVRQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPA
HHHHHHHHHCCHHHCCHHHHHHHHHHHHEEEEEECCCCEEECCCEEEEEECCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]