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The map label for this gene is rmlA1 [C]

Identifier: 73540428

GI number: 73540428

Start: 783373

End: 784083

Strand: Direct

Name: rmlA1 [C]

Synonym: Reut_A0722

Alternate gene names: 73540428

Gene position: 783373-784083 (Clockwise)

Preceding gene: 73540427

Following gene: 73540429

Centisome position: 20.58

GC content: 63.15

Gene sequence:

>711_bases
ATGAAGCCTGCTCTGATTCTTGCGGGCGGCCTGGGCACCAGGCTGCGTGCCGTCGTCGGGGAACTTCCCAAGCCTATGGC
CGATGTGGCCGGGCACCCGTTCCTATGGTGGCTGCTCAAGCAGCTCGACAAGCAAGGAGTCAAGGATGCTTACTTGTCCG
TTGGCTATCGGCATGAGATGGTGCGGGCAGGCATGGGCGACGTGTACGGGGCCATGCGCTTGCACTACATCGTCGAGGAG
AAGCCGCTGGGCACCGGTGGTGCCATCTTTAAGGCCGTTCAGGAAATCCCCGGCGAAGACGTGCTCGTGTTCAACGGCGA
TACGCTTGCCATGGTGGATCTGGCTGCATTCGTGGCGTTTGCCGATGCGAGCGGCGCCGACGTGGCCATGGCGGTCGCGC
GCGTGGAGGATGCCACCCGCTACGGAACTGTCGAGATCGATGCGGACCGGCGGATCCGCGCGTTCGTGGAGAAGGGGCGC
GGCGGGCCCGGGGTGATCAATGCCGGTGTCTATCAATTGCGCAAGCGTGCGCTGACCTCGCGCTCCGATCTGCCCGCGCG
GTTCTCGTTTGAACAGGATTTCCTGGCCCGGCTGTCCGGGACGCTGCATTTGGGTGCCTTTCTCGGTGTGACCGATTTCA
TCGACATCGGCATTCCGGAGGACTACCAGACCGCGCAAACCAAGGTCCCAGCGCTGATCGAGGCCATGTAA

Upstream 100 bases:

>100_bases
TCGAGATTCCGTCGACAGAGACCCCGAAAATCCAGGAAGGCCATCTGTTGCTCGGTCACATCATCTGCGGTCTCGTCGAG
GCTGCCATTTTCCCGCGCCA

Downstream 100 bases:

>100_bases
TGGGACAGCCGGCACTGTTCCTTGATCGCGATGGTGTGATCAACGTTGATACCGGTTACGTGCATTGCCCCGAAGATTGC
CGGTTTGTCGACGGCATTTT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKPALILAGGLGTRLRAVVGELPKPMADVAGHPFLWWLLKQLDKQGVKDAYLSVGYRHEMVRAGMGDVYGAMRLHYIVEE
KPLGTGGAIFKAVQEIPGEDVLVFNGDTLAMVDLAAFVAFADASGADVAMAVARVEDATRYGTVEIDADRRIRAFVEKGR
GGPGVINAGVYQLRKRALTSRSDLPARFSFEQDFLARLSGTLHLGAFLGVTDFIDIGIPEDYQTAQTKVPALIEAM

Sequences:

>Translated_236_residues
MKPALILAGGLGTRLRAVVGELPKPMADVAGHPFLWWLLKQLDKQGVKDAYLSVGYRHEMVRAGMGDVYGAMRLHYIVEE
KPLGTGGAIFKAVQEIPGEDVLVFNGDTLAMVDLAAFVAFADASGADVAMAVARVEDATRYGTVEIDADRRIRAFVEKGR
GGPGVINAGVYQLRKRALTSRSDLPARFSFEQDFLARLSGTLHLGAFLGVTDFIDIGIPEDYQTAQTKVPALIEAM
>Mature_236_residues
MKPALILAGGLGTRLRAVVGELPKPMADVAGHPFLWWLLKQLDKQGVKDAYLSVGYRHEMVRAGMGDVYGAMRLHYIVEE
KPLGTGGAIFKAVQEIPGEDVLVFNGDTLAMVDLAAFVAFADASGADVAMAVARVEDATRYGTVEIDADRRIRAFVEKGR
GGPGVINAGVYQLRKRALTSRSDLPARFSFEQDFLARLSGTLHLGAFLGVTDFIDIGIPEDYQTAQTKVPALIEAM

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=231, Percent_Identity=32.034632034632, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI11761619, Length=231, Percent_Identity=32.034632034632, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133931050, Length=225, Percent_Identity=32.8888888888889, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=29.0748898678414, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355443, Length=226, Percent_Identity=30.5309734513274, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644084, Length=226, Percent_Identity=30.5309734513274, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 25495; Mature: 25495

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPALILAGGLGTRLRAVVGELPKPMADVAGHPFLWWLLKQLDKQGVKDAYLSVGYRHEM
CCCCEEEECCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VRAGMGDVYGAMRLHYIVEEKPLGTGGAIFKAVQEIPGEDVLVFNGDTLAMVDLAAFVAF
HHHCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHH
ADASGADVAMAVARVEDATRYGTVEIDADRRIRAFVEKGRGGPGVINAGVYQLRKRALTS
CCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCC
RSDLPARFSFEQDFLARLSGTLHLGAFLGVTDFIDIGIPEDYQTAQTKVPALIEAM
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPALILAGGLGTRLRAVVGELPKPMADVAGHPFLWWLLKQLDKQGVKDAYLSVGYRHEM
CCCCEEEECCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VRAGMGDVYGAMRLHYIVEEKPLGTGGAIFKAVQEIPGEDVLVFNGDTLAMVDLAAFVAF
HHHCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHH
ADASGADVAMAVARVEDATRYGTVEIDADRRIRAFVEKGRGGPGVINAGVYQLRKRALTS
CCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCC
RSDLPARFSFEQDFLARLSGTLHLGAFLGVTDFIDIGIPEDYQTAQTKVPALIEAM
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA