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The map label for this gene is gmhA [H]

Identifier: 73540427

GI number: 73540427

Start: 782795

End: 783376

Strand: Direct

Name: gmhA [H]

Synonym: Reut_A0721

Alternate gene names: 73540427

Gene position: 782795-783376 (Clockwise)

Preceding gene: 73540426

Following gene: 73540428

Centisome position: 20.56

GC content: 59.62

Gene sequence:

>582_bases
ATGAGGCCGTTCATTGAGCAGGAAATTGACAAGGCGATTGGGATTTTCTCGAAGATCCGGCAAGACGACCTCCTGATAGA
ACGCGCCATGCAATGCGCTGACCGCATCTGCGATGCGCTGCGGGACGGCAAGAAGGTGCTTCTGGCAGGTAATGGCGGTA
GTGCCGCGGACGCTCAGCACATCGCCGGGGAATTCGTCAGCCGCTTTAACTACGACCGGCCGGGACTCTGTGCGTTCGCC
CTGACGGTGGATTCGTCCGTCATGACCGCGATCGGCAATGACTACGGCTATGAAAAGCTATTCGCCCGGCAGGTGCAGGC
GGTAGGTGCCCGTGGTGACATCTTCTGGGCCTACTCCACGTCGGGCAAATCGCTCAACGTGCTGCTGGCCATGGAGGAGG
CGCGCAAGGCAGGTCTGTTCGTGATTGGCTTCACCGGCCAACGGGGCTGGGTAAAGCCCGAGCTGTGTGACCTGTCCATC
GAGATTCCGTCGACAGAGACCCCGAAAATCCAGGAAGGCCATCTGTTGCTCGGTCACATCATCTGCGGTCTCGTCGAGGC
TGCCATTTTCCCGCGCCAATGA

Upstream 100 bases:

>100_bases
CTGCTCGCCGGCCTAGCGTCATGCGAACGCTGGCCGGTTTCAATGGTCAGGTATTTACCTGCAATTTCACCGAAAGCGGT
GCTCAATCCTGGAGAAAAGC

Downstream 100 bases:

>100_bases
AGCCTGCTCTGATTCTTGCGGGCGGCCTGGGCACCAGGCTGCGTGCCGTCGTCGGGGAACTTCCCAAGCCTATGGCCGAT
GTGGCCGGGCACCCGTTCCT

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MRPFIEQEIDKAIGIFSKIRQDDLLIERAMQCADRICDALRDGKKVLLAGNGGSAADAQHIAGEFVSRFNYDRPGLCAFA
LTVDSSVMTAIGNDYGYEKLFARQVQAVGARGDIFWAYSTSGKSLNVLLAMEEARKAGLFVIGFTGQRGWVKPELCDLSI
EIPSTETPKIQEGHLLLGHIICGLVEAAIFPRQ

Sequences:

>Translated_193_residues
MRPFIEQEIDKAIGIFSKIRQDDLLIERAMQCADRICDALRDGKKVLLAGNGGSAADAQHIAGEFVSRFNYDRPGLCAFA
LTVDSSVMTAIGNDYGYEKLFARQVQAVGARGDIFWAYSTSGKSLNVLLAMEEARKAGLFVIGFTGQRGWVKPELCDLSI
EIPSTETPKIQEGHLLLGHIICGLVEAAIFPRQ
>Mature_193_residues
MRPFIEQEIDKAIGIFSKIRQDDLLIERAMQCADRICDALRDGKKVLLAGNGGSAADAQHIAGEFVSRFNYDRPGLCAFA
LTVDSSVMTAIGNDYGYEKLFARQVQAVGARGDIFWAYSTSGKSLNVLLAMEEARKAGLFVIGFTGQRGWVKPELCDLSI
EIPSTETPKIQEGHLLLGHIICGLVEAAIFPRQ

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate [H]

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1789539, Length=160, Percent_Identity=39.375, Blast_Score=127, Evalue=3e-31,
Organism=Escherichia coli, GI1786416, Length=186, Percent_Identity=37.0967741935484, Blast_Score=124, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020620
- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: =5.3.1.28 [H]

Molecular weight: Translated: 21124; Mature: 21124

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPFIEQEIDKAIGIFSKIRQDDLLIERAMQCADRICDALRDGKKVLLAGNGGSAADAQH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
IAGEFVSRFNYDRPGLCAFALTVDSSVMTAIGNDYGYEKLFARQVQAVGARGDIFWAYST
HHHHHHHHCCCCCCCEEEEEEEECCHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGKSLNVLLAMEEARKAGLFVIGFTGQRGWVKPELCDLSIEIPSTETPKIQEGHLLLGHI
CCCEEEEEEEECHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHH
ICGLVEAAIFPRQ
HHHHHHHHHCCCC
>Mature Secondary Structure
MRPFIEQEIDKAIGIFSKIRQDDLLIERAMQCADRICDALRDGKKVLLAGNGGSAADAQH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
IAGEFVSRFNYDRPGLCAFALTVDSSVMTAIGNDYGYEKLFARQVQAVGARGDIFWAYST
HHHHHHHHCCCCCCCEEEEEEEECCHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGKSLNVLLAMEEARKAGLFVIGFTGQRGWVKPELCDLSIEIPSTETPKIQEGHLLLGHI
CCCEEEEEEEECHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHH
ICGLVEAAIFPRQ
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11373120; 12101286 [H]