Click here to switch to the map view.

The map label for this gene is mhpT [H]

Identifier: 73539979

GI number: 73539979

Start: 303708

End: 304979

Strand: Direct

Name: mhpT [H]

Synonym: Reut_A0273

Alternate gene names: 73539979

Gene position: 303708-304979 (Clockwise)

Preceding gene: 73539978

Following gene: 73539980

Centisome position: 7.98

GC content: 68.79

Gene sequence:

>1272_bases
ATGCAACCATCAAACAGCAGCGGCGCTAACGGGCGCAGCACAACAAGCAGCATCACCACCATCGGCCTGTGCCTGGCCAT
CGCCCTGCTGGAGGGGCTTGACTTGCAATCAGCCGGCGTCGCCGCGCCCCGCATAGCAAAGGAGTTCTCGCTGTCGGTGG
CGCAAATGGGCTGGGCCTTCAGTGCCGGCGCCATCGGCCTGCTGCCGGGCGCGGCGCTGGGCGGCCGGCTGGCTGATCGG
CTGGGCCGCAAGCGCGTGCTGATGCTGTCGGTCGCGCTGTTCGGCGCGTTCTCGCTGGCGACGACGCTCGTGTGGAACTT
TGAAAGCCTGCTGGCCGCGCGCCTGCTGACGGGCCTGGGCCTCGGCGCCGCCATGCCCAACCTGATCGCGCTGTGCTCGG
AAGCGGCGTCGCCCGCGCAGCGCAGCACCGCCGTTGGCGCGATGTACTGCGGCATGCCGTTCGGCGCAGCACTCGCCGCC
GCGATCGGGATCGTCAGCCCCGCTGACGAAGGCTGGCGGCACATCTTCTACGTGGGCGGCTTCGGGCCACTGCTGATGGT
GCCGCTGCTCGCGCTGTGGCTGTCCGAATCGGCACAGTTCGTCGAAGCAAAGTCGCAATCGGTGAAGCGCACCGAAGCCA
CGCCGGGCTTTGTCGAGGCGTTGTGCGGCGACGGCCGTACGCGTACCACGCTCGCGCTGTGGATCAGCTATCTGGGCACG
CTGATCGTGCTGTATTTCCTGATGAACTGGCTGCCCTCGATGGTGCTGTCCAACGGCCTGACACGAACGCAGGCGGGCAT
CGCAATGATGATGTTCAACATCGGTGGCGGCATCGGTGCGGTGGGCATCGCCAACGTGATGGACCGCTTCAGCCGCCGCC
TCACGGTGGTCGGCATGTACGTGGGCATCGGCGCCGCACTGGCGGGGCTGTCCGGCGCGGGCGGCAGTACTTCGATGGCG
GTCGGCGCATTCTTCTGCGGCCTGTTCCTCGTGGGCGGGCAGTCGGTGCTGTACGCGCTGGCCGGCCAGGCCTATCCGAC
GCAGGTGCGCGGCACAGGCGTAGGCGCGGCAGTCGCAATCGGCCGGCTGGGCTCGATCCTCGGGCCGCTCGTCGCCGGGC
AATTGTTCGCGCTGGGCCAGAGTGCGTCGATGCTGGTAGCCGCGAGCATTCCGCTGATCGTCATCGCCGCACTCGCCGCG
CTGGCGGTGGTGGGTTCATTCTCGCCGCGCCTGGCATCCGGCGCGGCAGTTCCAGGCGGGCGCGGCGCGTGA

Upstream 100 bases:

>100_bases
CCTACACCACCGAAATCGAAGGACTCGGCAGCGTCCGCGCGACGTTCGCCGCATAAGCCGTCACCAAGAGCGGCACACAC
AGACAAAAGCGGAGACAAGA

Downstream 100 bases:

>100_bases
GCGGCGCACTGTCAGCACATTCCATTCCCTACAGATTCAGTCGAGCAAGGAAGATCAACATGCAAGCGAACGTACAAGCC
ATCACCGAAGCCGGCACAAG

Product: putative 3-hydroxyphenylpropionic transporter MhpT

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MQPSNSSGANGRSTTSSITTIGLCLAIALLEGLDLQSAGVAAPRIAKEFSLSVAQMGWAFSAGAIGLLPGAALGGRLADR
LGRKRVLMLSVALFGAFSLATTLVWNFESLLAARLLTGLGLGAAMPNLIALCSEAASPAQRSTAVGAMYCGMPFGAALAA
AIGIVSPADEGWRHIFYVGGFGPLLMVPLLALWLSESAQFVEAKSQSVKRTEATPGFVEALCGDGRTRTTLALWISYLGT
LIVLYFLMNWLPSMVLSNGLTRTQAGIAMMMFNIGGGIGAVGIANVMDRFSRRLTVVGMYVGIGAALAGLSGAGGSTSMA
VGAFFCGLFLVGGQSVLYALAGQAYPTQVRGTGVGAAVAIGRLGSILGPLVAGQLFALGQSASMLVAASIPLIVIAALAA
LAVVGSFSPRLASGAAVPGGRGA

Sequences:

>Translated_423_residues
MQPSNSSGANGRSTTSSITTIGLCLAIALLEGLDLQSAGVAAPRIAKEFSLSVAQMGWAFSAGAIGLLPGAALGGRLADR
LGRKRVLMLSVALFGAFSLATTLVWNFESLLAARLLTGLGLGAAMPNLIALCSEAASPAQRSTAVGAMYCGMPFGAALAA
AIGIVSPADEGWRHIFYVGGFGPLLMVPLLALWLSESAQFVEAKSQSVKRTEATPGFVEALCGDGRTRTTLALWISYLGT
LIVLYFLMNWLPSMVLSNGLTRTQAGIAMMMFNIGGGIGAVGIANVMDRFSRRLTVVGMYVGIGAALAGLSGAGGSTSMA
VGAFFCGLFLVGGQSVLYALAGQAYPTQVRGTGVGAAVAIGRLGSILGPLVAGQLFALGQSASMLVAASIPLIVIAALAA
LAVVGSFSPRLASGAAVPGGRGA
>Mature_423_residues
MQPSNSSGANGRSTTSSITTIGLCLAIALLEGLDLQSAGVAAPRIAKEFSLSVAQMGWAFSAGAIGLLPGAALGGRLADR
LGRKRVLMLSVALFGAFSLATTLVWNFESLLAARLLTGLGLGAAMPNLIALCSEAASPAQRSTAVGAMYCGMPFGAALAA
AIGIVSPADEGWRHIFYVGGFGPLLMVPLLALWLSESAQFVEAKSQSVKRTEATPGFVEALCGDGRTRTTLALWISYLGT
LIVLYFLMNWLPSMVLSNGLTRTQAGIAMMMFNIGGGIGAVGIANVMDRFSRRLTVVGMYVGIGAALAGLSGAGGSTSMA
VGAFFCGLFLVGGQSVLYALAGQAYPTQVRGTGVGAAVAIGRLGSILGPLVAGQLFALGQSASMLVAASIPLIVIAALAA
LAVVGSFSPRLASGAAVPGGRGA

Specific function: Could be a transporter for 3-phenylpropionate (hydrocinnamic acid) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI166064021, Length=379, Percent_Identity=23.7467018469657, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081723, Length=380, Percent_Identity=50.7894736842105, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1786229, Length=394, Percent_Identity=23.8578680203046, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082231, Length=223, Percent_Identity=26.457399103139, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788068, Length=345, Percent_Identity=23.1884057971014, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789152, Length=316, Percent_Identity=23.4177215189873, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=386, Percent_Identity=22.279792746114, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922874, Length=427, Percent_Identity=22.248243559719, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42668; Mature: 42668

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00879 ODR_DC_2_2 ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSNSSGANGRSTTSSITTIGLCLAIALLEGLDLQSAGVAAPRIAKEFSLSVAQMGWAF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
SAGAIGLLPGAALGGRLADRLGRKRVLMLSVALFGAFSLATTLVWNFESLLAARLLTGLG
CCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LGAAMPNLIALCSEAASPAQRSTAVGAMYCGMPFGAALAAAIGIVSPADEGWRHIFYVGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEECC
FGPLLMVPLLALWLSESAQFVEAKSQSVKRTEATPGFVEALCGDGRTRTTLALWISYLGT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
LIVLYFLMNWLPSMVLSNGLTRTQAGIAMMMFNIGGGIGAVGIANVMDRFSRRLTVVGMY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VGIGAALAGLSGAGGSTSMAVGAFFCGLFLVGGQSVLYALAGQAYPTQVRGTGVGAAVAI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHH
GRLGSILGPLVAGQLFALGQSASMLVAASIPLIVIAALAALAVVGSFSPRLASGAAVPGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
RGA
CCC
>Mature Secondary Structure
MQPSNSSGANGRSTTSSITTIGLCLAIALLEGLDLQSAGVAAPRIAKEFSLSVAQMGWAF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
SAGAIGLLPGAALGGRLADRLGRKRVLMLSVALFGAFSLATTLVWNFESLLAARLLTGLG
CCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LGAAMPNLIALCSEAASPAQRSTAVGAMYCGMPFGAALAAAIGIVSPADEGWRHIFYVGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEECC
FGPLLMVPLLALWLSESAQFVEAKSQSVKRTEATPGFVEALCGDGRTRTTLALWISYLGT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
LIVLYFLMNWLPSMVLSNGLTRTQAGIAMMMFNIGGGIGAVGIANVMDRFSRRLTVVGMY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VGIGAALAGLSGAGGSTSMAVGAFFCGLFLVGGQSVLYALAGQAYPTQVRGTGVGAAVAI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHH
GRLGSILGPLVAGQLFALGQSASMLVAASIPLIVIAALAALAVVGSFSPRLASGAAVPGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
RGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]